Effects of dietary sodium and potassium on serum uric acid concentration (S-UA) and urinary uric acid excretion (U
UA) in Japanese young women were studied in this paper.
Subjects (n=4, female, l9yrs) were fed w ith low sodium (Na), potassium (K) diet for four days, thereafter fed with relatively higher Na, K diet for successive four days. S-UA was determined at first, fourth and eighth experimental days. U
UA and urinary electrolytes excretion were measured throughout experiment.
S-UA was decreased, while urine volume (U
V), urinary Na (U
Na), K (U
K) excretion, U
UA and urinary creatinine excretion (U
Cr) were increased, accompanied with the increase in dietary electrolytes intake.
Urinary uric acid concentration was significantly correlated to urinary creatinine concentration (r=0.88), K concentration (r=0.71), (Na+K) concentration (r=0.49) and Na/K ratio (r=-0.43).
Urinary uric acid excretion was correlated to U
UA/
UCr(r=0.59), U
Cr (r=0.56) and U
K (r=0.45).
These results sugge s ted that uric acid metabolism was influenced by dietary electrolytes levels. And it was also suggested that renal uric acid handling was partly correlated to urinary sodium and potassium excretions. A possible roles of electrolytes on dietary treatment for hyperuricemia were discussed.
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