Of great importance for the success of anticoagulant treatment is the control of anticoagulants. An ideal test for the control of these drugs should indicate the opimum dosage for benefiting the thrombotic condition and also give warning of incipient hemorrhage from over-dosage.
Among the various types of clotting test, the prothrombin time test (Quick's one-stage method
1)) has been most widely propagated for a long time. Owren and Aas introduced P&P test
2) subsequently and did thrombotest
3) recently. The former was thought to reflect sensitively the combined changes in prothrombin (factor II), proconvertin (factor VII) and Stuart-Prower factor (factor X), and the latter was shown to be sensitive to changes in PTC (factor IX) in addition to prothrombin, factor VII and factor X. Today, these three types of test are adopted widely but the evaluation of each method is still divergent with different authors.
4)5)6) Some authors are prone to use Quick's test, while the others P&P test or thrombotest. These disagreements may be due mainly to incomplete comparative study about these procedures. It is noteworthy to recommend the most reliable test for accurate appraisement and development of anticoagulant therapy. The object of this paper is to attempt to compare the reliability of above three methods both clinically and hematologically.
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