Although many previous studies on the signal detection of adverse drug reaction using data mining methods in JADER, a domestic spontaneous reporting database, have been reported, standardized procedures for pharmaceutical companies to detect signals in their products have not yet been presented. In this study, we retrospectively examined whether signals could be detected earlier by using data-mining methods in adverse drug reactions (interstitial pneumonia under DOAC use) that were added in a revised package insert after launch, with the aim of providing useful practices for company practice. The results showed that early detection was achieved for two of the four targeted DOACs. Although early detection was not achieved for the remaining two products, important considerations for the application of the method could be discussed. The results of this study are expected to enhance the detection of adverse drug reaction signals through the introduction of data mining methods using JADER in the safety surveillance activities of companies.

　Nurse administrators must evaluate and comprehend nurses' practical competence in their wards' management. The evaluation perspective is not only limited to what can be seen but also the thinking process that takes place in the nurse's mind. However, the criteria for evaluation are not clear yet. Therefore, we conducted a questionnaire survey to determine from what perspective nurse administrators evaluate the ability of staff members to process information in their minds (human information processing skills). The results revealed that the perspectives from which nurse administrators consider the human information processing skills of their staff consist of “knowledge management skills,” “cognitive data processing that supports patient orientation,” and “thinking skills that support cognitive data processing.”. In addition, it shows that human information processing skills, which should be invisible to others, can be evaluated by others.

　The purpose of this study was to clarify the effects of learning using e-learning materials on the basics of dementia nursing care for nurses working in various types of facilities based on their scores for the basic knowledge of dementia and self-evaluated dementia care skills. Responses were obtained from 1,010 nurses, who had worked in 31 facilities of a corporate organization. Among these nurses, 375 had and 635 did not have e-learning experience. Multiple regression analysis was performed using basic knowledge of dementia and scores of self-assessment type dementia care skills as objective variables. As a result, it was found that the 3 factors : the 〈status of taking training courses〉, 〈facility〉, and 〈status of e-learning〉 are related to the basic knowledge of dementia and the score of self-assessment type dementia care skill.