Japanese Journal of Physiological Anthropology
Online ISSN : 2432-0986
Print ISSN : 1342-3215
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Review
  • Fumio YAMADA
    2022 Volume 27 Issue 4 Pages 103-112
    Published: November 25, 2022
    Released on J-STAGE: November 26, 2022
    JOURNAL FREE ACCESS

    The startle blink reflex is evoked by a sudden, sharp and loud sound stimulus. When a weak stimulus is added just before the provocative stimulus, the reflex is inhibited. This phenomenon, termed prepulse inhibition (PPI), is a robust phenomenon identified in rats and humans. However, PPI disappears or attenuates in patients with schizophrenia. It is hypothesized that preattentional processes in the central nervous system are involved in the expression of PPIs, and many experimental and clinical studies have been reported.

    In this paper, after reviewing the research related to PPI, we introduced the research on PPI of the startle eyeblink reflex in humans that the authors have been involved in, and mentioned the necessary research in the future.

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