We always diagnose migraine using the International Classification of Headache Disorders criteria (version 3). However, since this criteria depends on clinical symptoms and the pathophysiology of migraine is not fully understood, diagnosis sometimes differs between doctors. Hence, we investigate for an appropriate diagnostic biomarker of migraine using the omics approach—a comprehensive analysis of transcriptome, proteome, and genome. Dysfunctions of α-fodrin, apolipoprotein E, and GC-binding protein were found to be candidate biomarkers through proteome, transcriptome, and genome analyses, respectively. Although currently we cannot narrow down to one candidate biomarker, this can be subsequently achieved by evaluating a larger number of patients.

We have previously reported black tea aroma exhibits a sedative effect by suppressing sympathetic nerve activity and elevating parasympathetic nerve activity. Enhancement of sleep quality is also expected from the sedative effect of this aroma. The effect of black tea aroma on sleep in 20 women with high stress consciousness and sleep disorders; was evaluated in this study using data collected from questionnaires and physical activity measured over a 14 day test period. Psychological effects of reduced stress consciousness were improvement in sleep quality, and greater satisfaction with ease in falling and staying asleep; while physiological data showed reduced sleep latency, an increase in total sleep time, and a significant increase in sleep efficiency. These results strongly suggest black tea aroma improves overall sleep.

Intradialytic hypotension (IDH) is the most common dialysis complication. Previous studies have indicated that elderly people, diabetes, malnutrition, anemia, and cardiac dysfunction are particularly likely to cause IDH. Many researches tried to identify IDH using bio signals. However, despite challenging the development of prediction methods, there are hardly any research clinically implemented. In this paper, we propose several methods for predicting IDH using bio signal processing specifically new parameter.