An abnormally accelerated Ca-induced Ca release (CICR) rate is known to be correlated with malignant hyperthermia susceptibility (MHS) . Kawamoto et al. developed a computer program (CICRpred) for predicting the results of the CICR test. We evaluated the CICRpred with cases who received a biopsied CICR test (b-CICR) in our institute.
Fourteen patients (male/female : 9/5) who were suspected of MHS and who had received b-CICR were enrolled in this study. Eight variables were inputted for calculation with CICRpred. The results of CICRpred were compared with the results of b-CICR.
Eight patients, 4 abnormal and 4 normal in b-CICR, were diagnosed as abnormal by CICRpred and 6 patients, 1 abnormal and 5 normal in b-CICR, had normal results. In this computer program, we determined that the CICRpred had a sensitivity of 80%, a specificity of 56%, a positive predictive value of 50%, and a negative predictive value of 83%.
We concluded that the CICRpred is a useful program as a screening test in clinical settings because of harmlessness, its easy input, and good sensitivity.
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