We evaluated changes in intra-ocular pressure (IOP) and cerebral hemoglobin oxygen saturation (rSO
2) during laparoscopic surgery in the Trendelenburg position(n=16) Continuous lumbar epidural block with 1.5% mepivacain was performed on all patients. These patients were allocated randomly to two groups: continuous propofol infusion group (group Epi+Propofol) and isoflurane, oxygen and nitrous-oxide group (group Epi+GOT). In group Epi+GOI, the IOP elevated significantly 30min after the intra-abdominal CO
2 insufflation and Trendelenburg positioning. However, in group Epi+Propofol, the IOP did not show any change throughout the study, and was significantly lower than that in group Epi+GOI. The rSO
2 in both groups did not change throughout the study, and no significant differences were observed between two groups. Therefore, propofol did not increase IOP during laparoscopic surgery in the Trendelenburg position.
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