We examined the protective effect of pamicogrel, a new antiplatelet drug, on the sodium laurate-induced peripheral arterial occlusive disease of posterior limb in the guinea-pig, and compared its effect with those of acetylsalicylic acid, ticlopidine and cilostazol. In the control group given saline alone, the sodium laurate injection at 1mg/leg into the right femoral artery caused an ischemic change in the peripheral posterior limb followed by apprearance of violet color around the whole paw, edema, gangrene, mummification and falling off of fingers, whole paw and lower leg after 3 to 14 days. Decrease of the skin temperature at the site of sodium laurate injection was significantly inhibited as compared with that of the control group on days 1 and 3. Oral administration of pamicogrel (0.1, 0.3 and 1 mg/kg, p.o.)and ticlopidine (100 and 300 mg/kg, p.o.) 1 hr after the injection of sodium laurate and successively once a day over a period of 14 days dose-dependently inhibited the development of ischemic lesion in the posterior limb and decrease the skin temperature of the ipsilateral thigh. In contrast, acetylsalicylic acid given at 10 and 30 mg/kg (p.o.) significantly exacerbated the development of ischemic lesion in the ipsilateral limb on day 3, and on days 3, 7 and 10, respectively, but not at 100 mg/kg (p.o.). On the other hand, cilostazol (10 and 30 mg/kg, p.o.) had little preventive effect on the progression of ischemic lesion and the decrease of skin temperature of the ipsilateral thigh.
These observations suggest that pamicogrel can be clinically effective against chronic arterial occlusive diseases.

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