Japanese Journal of Thrombosis and Hemostasis
Online ISSN : 1880-8808
Print ISSN : 0915-7441
ISSN-L : 0915-7441
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Volume 23, Issue 5
Displaying 1-14 of 14 articles from this issue
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Reviews : Reviews of gene analysis and gene-based testing in thrombosis and hemostasis
Reviews
  • Structure and function of serpins involved in the regulation of blood coagulation and fibrinolysis
    Tatsuya HAYASHI, Koji SUZUKI
    2012 Volume 23 Issue 5 Pages 481-493
    Published: October 01, 2012
    Released on J-STAGE: November 09, 2012
    DOIhttps://doi.org/10.2491/jjsth.23.481
    JOURNAL FREE ACCESS
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  • The blood coagulation factor IX inhibitor
    Takashi SUZUKI
    2012 Volume 23 Issue 5 Pages 494-505
    Published: October 01, 2012
    Released on J-STAGE: November 09, 2012
    DOIhttps://doi.org/10.2491/jjsth.23.494
    JOURNAL FREE ACCESS
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    Anti factor IX antibodies (FIX inhibitors) develop in 1.5-3% of congenital hemophilia B patients as alloantibodies and are very rarely seen in non-hemophilic individuals as autoantibodies. The incidence of FIX inhibitor development in hemophilia B is very low in contrast to hemophilia A. In particular, an allergic reaction to an exogeneous FIX protein is a major peculiarity among these patients. Due to the low incidence and small number of cases, there has been insufficient basic and clinical research to properly investigate FIX inhibitor development in congenital hemophilia B patients. Recently, several risk factors, including genetics and environment, for inhibitor formation have been hypothesized. The clinical manifestations and progress in both the treatment for bleeding and inhibitor eradication and the risk factors of for FIX inhibitor development will be introduced in this review.
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Technical Lecture
Topics
Structure-function relationships of proteins involved in coagulation, fibrinolysis and platelet functions
Small talks on my research career
Report for the 34th Congress of the Japanese Society on Thrombosis and Hemostasis
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