Japanese Journal of Thrombosis and Hemostasis
Online ISSN : 1880-8808
Print ISSN : 0915-7441
ISSN-L : 0915-7441
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Volume 22, Issue 6
Displaying 1-8 of 8 articles from this issue
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Reviews : ISTH-Kyoto2011
  • Molecular analysis of Blood Vessel Maturation
    Nobuyuki TAKAKURA
    2011 Volume 22 Issue 6 Pages 343-347
    Published: December 01, 2011
    Released on J-STAGE: December 22, 2011
    DOIhttps://doi.org/10.2491/jjsth.22.343
    JOURNAL FREE ACCESS
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    Blood vessels constructed by vasculogenesis are immature. For the maturation of vessel structure, mural cells (MCs), such as pericytes or smooth muscle cells, have to adhere to endothelial cells (ECs). In the maturation process involved in blood vessel formation, the ECs which form the tube, recruit supporting MCs, by releasing PDGF-BB. MCs subsequently adhere to ECs resulting in the formation of a structurally-stable blood vessel. It has been proposed that this cell adhesion between ECs and MCs is induced when angiopoietin-1, produced from MCs, stimulates Tie2, a receptor tyrosine kinase on ECs. During angiogenesis, blood vessels should be able to adjust their caliber, in order to allow them to respond adequately to the changes in demand for oxygen and nutrients made by the organs and tissues. This caliber adjustment is involved in the maturation process during angiogenesis. Apelin, produced from ECs via activation of Tie2 stimulates APJ, a GPCR expressed on ECs induces non-leaky enlarged blood vessels. Besides such molecular signals for blood vessel maturation, recently it has been clarified that phalanx cells among ECs induce maturation of blood vessels.
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  • Novel platelet activation receptor CLEC-2
    from discovery to prospects
    Katsue SUZUKI-INOUE, Osamu INOUE, Yukio OZAKI
    2011 Volume 22 Issue 6 Pages 348-362
    Published: December 01, 2011
    Released on J-STAGE: December 22, 2011
    DOIhttps://doi.org/10.2491/jjsth.22.348
    JOURNAL FREE ACCESS
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  • Future prospective of phosphodiesterase-3 inhibitors as antithorombotic drug
    Masakatsu NISHIKAWA, Hiroyoshi HIDAKA
    2011 Volume 22 Issue 6 Pages 363-367
    Published: December 01, 2011
    Released on J-STAGE: December 22, 2011
    DOIhttps://doi.org/10.2491/jjsth.22.363
    JOURNAL FREE ACCESS
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  • ADAMTS13 of Japanese people
    Koichi KOKAME
    2011 Volume 22 Issue 6 Pages 368-373
    Published: December 01, 2011
    Released on J-STAGE: December 22, 2011
    DOIhttps://doi.org/10.2491/jjsth.22.368
    JOURNAL FREE ACCESS
    Download PDF (5063K)
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