Japanese Journal of Thrombosis and Hemostasis
Online ISSN : 1880-8808
Print ISSN : 0915-7441
ISSN-L : 0915-7441
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Volume 33, Issue 5
Displaying 1-15 of 15 articles from this issue
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Editorial
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Topics: A new series “COVID-19 Infecion”
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Original article
  • Evaluation of blood hemostatic molecular markers, cytokine and adhesion molecule levels in patients with aortic aneurysm as risk factors for future mortality
    Akihiro IHARA
    Article type: Original article
    2022 Volume 33 Issue 5 Pages 586-592
    Published: 2022
    Released on J-STAGE: October 15, 2022
    DOIhttps://doi.org/10.2491/jjsth.33.586
    JOURNAL FREE ACCESS FULL-TEXT HTML
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    Coagulation fibrinolysis markers, cytokines and adhesion molecules were examined to determine the prognosis of chronic phase aortic aneurysms (AAs). Blood was collected from 27 chronic phase AA patients without acute symptoms and 102 age-matched controls, and blood concentrations of CRP, IL-6, TNF-α, sIL-2R, sICAM-1, PAI-1 antigen, D-dimer, PIC, TAT, VWF: Ag were measured. With the exception of TNF-α and sICAM-1, AA showed significantly higher values than the controls. CRP could not be compared because it had not been measured in the controls. Patients were classified into a “high group” with blood levels higher than the median of each marker and a “low group” with a median or less. According to the Kaplan-Meier method, the “high group” of CRP, sIL-2R, PAI-1, D-dimer, TAT, and VWF: Ag showed significantly lower cumulative survival rates compared to the “low group”. The above six markers were thought to reflect the underlying pathophysiologic state and clinical course of chronic stage AA.

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