Japanese Journal of Thrombosis and Hemostasis

Online ISSN : 1880-8808
Print ISSN : 0915-7441
ISSN-L : 0915-7441

Search
Browse

All issues

Predecessor

Volume 24, Issue 6

Displaying 1-20 of 20 articles from this issue

Download citation

Show all abstracts

Reviews : Functional imaging of vasculature and vascular endothelial cells

Understanding of angiogenic morphogenesis using in vitro timelapse live imaging and quantitative approaches

Koichi NISHIYAMA

2013 Volume 24 Issue 6 Pages 553-559
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.553

JOURNAL FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (8306K)
Analysis of PI3K-C2α-mediated endothelial signaling using live-cell fluorescence imaging

Kazuaki YOSHIOKA, Noriko TAKUWA, Yasuo OKAMOTO, Yoh TAKUWA

2013 Volume 24 Issue 6 Pages 560-568
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.560

JOURNAL FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (5661K)
Dynamic imaging of flow-induced endothelial cell responses

Kimiko YAMAMOTO, Joji ANDO

2013 Volume 24 Issue 6 Pages 569-575
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.569

JOURNAL FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (7902K)
Imaging analysis of flow-induced vascular network formation

Ryo SUDO

2013 Volume 24 Issue 6 Pages 576-581
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.576

JOURNAL FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (3492K)
Intravital fluorescent imaging of angiogenesis

Takeshi IMAMURA, Atsuhiko HIKITA, Yusuke OSHIMA, Shigehiro KOGA

2013 Volume 24 Issue 6 Pages 582-587
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.582

JOURNAL FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (3857K)
Visualization of thrombus formation in vivo

Satoshi NISHIMURA

2013 Volume 24 Issue 6 Pages 588-592
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.588

JOURNAL FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (4293K)

Original Article

Long-term safety and efficacy of recombinant activated factor VII （NovoSeven^Ⓡ） for treatment of acute bleeding episodes in congenital hemophilia with inhibitors：analysis from 10-year japanese post-marketing surveillance

Akira SHIRAHATA, Mitsuhiro KUWAHARA, Katsuyuki FUKUTAKE, Satoshi HIGAS ...

2013 Volume 24 Issue 6 Pages 593-602
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.593

JOURNAL FREE ACCESS

Show abstractHide abstract

This article describes an analysis of the long-term safety and efficacy of recombinant activated factor VII （rFVIIa） over a 10-year period. From the data of 1,718 bleeding episodes in 142 congenital hemophilia patients with inhibitors, 65％ showed improved clinical symptoms within 12 hours after rFVIIa injection. Overall, 88％ of bleeding episodes improved following treatment with rFVIIa. Median treatment was dosing period of 1.0 day with 3.0 injections of 103 μg/kg rFVIIa in the patient group without concomitant use of other hemostatic agents. Joint bleeds were most common （63％）, followed by muscle bleeds （14％） and subcutaneous hemorrhages （9％）. The dosing period was significantly longer for intracranial hemorrhage and gastrointestinal bleeds, and hematuria. Out of 8,097 bleeding episodes and a total of 24,778 injections in 144 patients, 5 thromboembolic events were reported in 4 patients.

View full abstract

Download PDF (1640K)

Topics

Endovascular treatment for acute ischemic stroke

Shinichi YOSHIMURA

2013 Volume 24 Issue 6 Pages 603-608
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.603

JOURNAL FREE ACCESS

Show abstractHide abstract

Intravenous recombinant tissue plasminogen activator （IV rt-PA） was approved in 2005 in Japan, and it had a significant impact on acute stroke therapy. More than 50,000 patients were treated so far, but low adaptation rate of IV rt-PA was regarded as problem. Merci retriever and Penumbra system were approved in 2010 and 2011, respectively, and gradually spreading in Japan. However, the results of 3 randomized controlled trials were all negative in terms of superiority or non-inferiority of endovascular treatment compared to IV rt-PA or standard care. Next generation devices such as stent-like retrievers were shown to have better effect in clinical outcome compared to Merci retriever. It is expected that the efficacy of endovascular treatment will be confirmed by randomized controlled trials in the near future.

View full abstract

Download PDF (2125K)
Unique effect of blood coagulation factor X to the liver transduction：Defense from complement and immune attack

Takashi MORITA

2013 Volume 24 Issue 6 Pages 609-612
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.609

JOURNAL FREE ACCESS

Download PDF (10047K)

Structure-function relationships of proteins involved in coagulation, fibrinolysis and platelet functions

Structural and functional analysis of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism

Masashi AKIYAMA, Soichi TAKEDA, Toshiyuki MIYATA

2013 Volume 24 Issue 6 Pages 613-618
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.613

JOURNAL FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (2448K)

2013 revised edition : hemostatic treatment guidelines for hemophilia patients without inhibitors

2013 Volume 24 Issue 6 Pages 619-639
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.619

JOURNAL FREE ACCESS

Download PDF (2487K)
2013 revised edition : hemostatic treatment guidelines for inhibitors possess congenital hemophilia patients

2013 Volume 24 Issue 6 Pages 640-658
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.640

JOURNAL FREE ACCESS

Download PDF (1161K)

Report

Report of Scientific Promotion Committee 2013

[in Japanese]

2013 Volume 24 Issue 6 Pages 659-660
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.659

JOURNAL FREE ACCESS

Download PDF (1737K)
Report of Scientific Promotion Committee 2013

[in Japanese]

2013 Volume 24 Issue 6 Pages 661-663
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.661

JOURNAL FREE ACCESS

Download PDF (1212K)

Small talks on my research career

Some reminiscences in Nagoya and Cleveland

Hidehiko SAITO

2013 Volume 24 Issue 6 Pages 664-668
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.664

JOURNAL FREE ACCESS

Download PDF (1470K)

6th Daiichi-Sankyo Symposium for Thrombosis Update

Bleeding assessment tools

Paula JAMES

2013 Volume 24 Issue 6 Pages 670-674
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.670

JOURNAL FREE ACCESS

Download PDF (1362K)
PAMPs/DAMPs as novel mediators of inflammation-associated thrombosis

Takashi ITO

2013 Volume 24 Issue 6 Pages 675-679
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.675

JOURNAL FREE ACCESS

Download PDF (5411K)
Novel markers for differential diagnosis and treatment to thrombotic thrombocytopenic purpura （TTP） and hemolytic uremic syndrome （HUS）

Yoshihiro FUJIMURA

2013 Volume 24 Issue 6 Pages 680-684
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.680

JOURNAL FREE ACCESS

Download PDF (1668K)
Current status of diagnosis and therapeutic strategy in the patients with Peripheral Arterial Disease（PAD）

Kimihiro KOMORI

2013 Volume 24 Issue 6 Pages 685-689
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.685

JOURNAL FREE ACCESS

Download PDF (3407K)

Journal Club

2013 Volume 24 Issue 6 Pages 690-692
Published: December 01, 2013
Released on J-STAGE: January 21, 2014

DOIhttps://doi.org/10.2491/jjsth.24.690

JOURNAL FREE ACCESS

Download PDF (890K)

feedback

Top

Register with J-STAGE for free!