Clinico-histopathological study inclusing steroid effects on primary nephrotic syndrome of 56 cases was performed and carried out the following results. Each cases were examined with electron microscopy and Lounted the mean values of the width of basement membrane of capillary loops.They were divided three groups according the width of basement membrane ; 1) less than 5000Å, 2) 5000-10000Å, 3) more than 10000Å. The thickening of basement membrane were closely related the clinical responsibility of steroid hormon. The first group, less than 5000Å was very effected with steroid treatment, but the third group, more than 10000Å was no responsed with the same therapy. The second group, 500010000Å, however, was showed no constant effect to steroid therapy. The third group consisted with all membranous glomerulonephritis electron microscopically. The first group, however, consisted with minimal change.
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