To elucidate the viral accumulation mechanism and distribution in oyster digestive diverticulum, in situ hybridization was carry out using the oyster introduced
Feline calicivirus F4 strain as a surrogate for
Norovirus. As a result of hybridization, coloration was observed in the pipe, narrow tube and diverticulum, which compose the oyster digestive diverticulum, indicating that the virus is taken into the cells in the ascidiate region.
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