Recent developments in the field of human genomics have greatly enhanced the potential for precision and personalized medicine. We have developed a novel DNA microarray, using a 3-mm square chip coated with diamond-like carbon to enhance the signal-to-background ratio, for use as an in vitro diagnostic tool in precision medicine. To verify the genotyping effectiveness of this newly developed DNA microarray we examined UDP-glucuronosyltransferase 1A1（UGT1A1）polymorphisms in DNA extracted from patients with metastatic colorectal cancer. It is established that the polymorphisms of UGT1A1＊28 and UGT1A1＊6 are significantly associated with severe toxicity induced by the anti-cancer drug irinotecan. For each sample, the results obtained with the novel microarray platform were compared with those obtained using other, more established, methods, including direct sequencing and the Invader assay. The polymorphisms tested included a single nucleotide substitution（UGT1A1＊6）and a TA-repeat polymorphism（UGT1A1＊28），both of which were detected simultaneously and accurately using our method. Moreover, our method required 1.5-fold less time to assay and 20-fold less sample than those required by the Invader assay. In summary, our newly developed DNA microarray is more practical than established methods, and is at least as accurate；this will increase the efficiency of polymorphism detection prior to diagnosis and the commencement of treatment, and can feasibly be applied in precision medicine.

This study investigates the actual condition of and staff satisfaction with end-of-life care（EOLC）in community-based long-term nursing multifunctional small group homes（NMSGHs）to design an appropriate community-based support project for implementing aging in place. This study aimed to determine and promote EOLC and satisfaction of the staff, patients, and their family members in other community-based services（CBSs），such as group homes for people with dementia. We conducted an anonymous self-administered questionnaire survey among the staff of NMSGHs and analyzed 84 valid responses from 44 nurses and 40 care workers. In total, 92.7 % of NMSGHs provided EOLC. As the number of full-time nurses increased, a corresponding increase was seen in EOLC, showing a positive correlation. The quantum of EOLC was related to the perceived satisfaction of patients, their family members, and care workers, but it decreased nurses’satisfaction. In order to promote EOLC and staff satisfaction among CBSs including NMSGHs, education and training programs for staff development should be provided. Providing online EOLC education and training by linking a wide range of community professionals and CBSs are recommended to improve not only the quality but also the quantum of EOLC at CBSs to realize aging in place.