Each of ten female pigs was administered prostaglandin F
2α (PGF
2α) : 15mg for Group I, 10mg for Group II, 5mg for Group III, or saline for the control twice daily for 3 days from Day 8 to Day 10, defining Day 0 as the last day of the previous estrus, to examine its effects on inter-estrous interval and reproductive performance. The inter-estrous intervals in Groups I, II, and III were 15.7±0.6 days, 17.9±3.8 days, and 17.5±2.5 days, respectively, and were significantly shorter than that in the control group (21.2±1.2 days). In Groups II and III, the inter-estrous intervals of each 3 animals did not shorten, ranging from 21 to 26 days. In the control group, the blood progesterone concentration decreased gradually from Day 14, reaching 1ng/m
l on Day 18, and leveled off until the return of estrus. In the PGF
2α treated groups, except for the pigs whose estrous cycles were not shortened, the progesterone level was significantly lower than in the control group between Day 10 to 14, sharply decreased from Day 10 and leveled off in the 1ng/m
l range from Day 12 until the onset of estrus. Of the pigs whose estrous cycles were not shortened, the progesterone levels showed some fluctuation during the administration of PGF
2α, increased after the administration, and remained at high levels until Day 15-21. Indicators of reproductive performance such as gestation period, litter size, and birth weight induced by PGF
2α were found to be standard. These results indicate that 15mg of PGF
2α for one dose is necessary to ensure success in shortening the inter-estrous interval because the inter-estrous intervals of some pigs under reduced doses did not shorten.
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