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Volume 22 (2007)
- Issue 6 Pages 620-
- Issue 5 Pages 510-
- Issue 4 Pages 424-
- Issue 2 Pages 108-
- Issue 1 Pages 28-
Volume 22, Issue 4
Displaying 1-6 of 6 articles from this issue
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Feature articles “Skin barrier function and recent trend in transdermal drug delivery systems” Editor : Kenji Sugibayashi
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Yasuo Kitajima2007 Volume 22 Issue 4 Pages 424-432
Published: 2007
Released on J-STAGE: October 02, 2007
JOURNAL FREE ACCESSThe most important structure for the maintenance of epidermal barrier function between air and water environments is the lipid lamellar layer in the stratum corneum (StC). It is epidermal keratinocytes that generate this lipid layer and maintain it in StC, which is in tern generated by keratinization of keratinocytes. To hold lipid layers in StC in a flexible and stead way, keratinocytes integrate different junctions, as such desmosome, tight, gap and adherens, desmosome and adherens junction of which are associated with cytoskeletons, into the epidermal sheet and these junctions regulate keratinaization. The molecular defects of these junctions and keratinization exert impairments of epidermal barrier function. The control of these molecules may provide us with a clue for the control of DDS.View full abstractDownload PDF (854K) -
Motoji Takahashi2007 Volume 22 Issue 4 Pages 433-441
Published: 2007
Released on J-STAGE: October 02, 2007
JOURNAL FREE ACCESSMany noninvasive techniques to measure skin physiological properties have been developed in skin bioengineering field. They are measurement of water content of stratum corneum, skin surface contour, TEWL(transepidermal water loss), skin color, blood flow, sebum secretion rate and so on. In addition to above methods, recently, a few bio-microscopes which can examine the inside of the skin in vivo have been developed and applied to skin absorption of drugs. I describe in this paper the study on drug delivery using in vivo confocal Raman microscopy and multiphoton microscopy.View full abstractDownload PDF (1084K) -
Richard H Guy2007 Volume 22 Issue 4 Pages 442-449
Published: 2007
Released on J-STAGE: October 02, 2007
JOURNAL FREE ACCESSTransdermal drug delivery represents a validated technology which is contributing significantly to global pharmaceutical care. Over the last 40 years, impressive growth in this field has been observed with many commercial successes;indeed, very recently, a new chemical entity has been developed and approved for transdermal administration without first passing via an injectable or oral dosage form. The progress achieved has been catalyzed by the clearer understanding of skin barrier function, and of the physicochemical, pharmacokinetic and physiological factors which determine the feasibility of transdermal administration. Research into novel, non-invasive approaches to facilitate and control drug transport across the skin is intensive, with certain technologies, such as iontophoresis, now achieving true maturity. Advances in the field have also allowed the "local", subcutaneous delivery of drugs (for example, to underlying muscle and other tissues) to be improved and the opening of new markets in this lucrative area may be envisaged.View full abstractDownload PDF (300K) -
Tetsuya Watanabe2007 Volume 22 Issue 4 Pages 450-457
Published: 2007
Released on J-STAGE: October 02, 2007
JOURNAL FREE ACCESSRecently transdermal therapeutic systems(TTS) have been paid attention and thought to be greatly useful in patients due to advanced technology in enhancement of skin permeation and decreased side effect on the skin after the TTS was removed. Fentanyl TTS for the narcotic analgesics, tulobuterol tape for the asthma treatment and oxybutynin TTS for the urine incontinence treatment are of the examples. When the TTS products which are requested by the patients can be developed, they must be a target for the global development like oral formulations.
Here, I review the advantage and mechanism of the TTS products such as Durotep Patch, Hokunalin Tape, Oxytrol and Lidoderm in this report.View full abstractDownload PDF (1084K) -
Nobuko Hada, Hiroaki Todo, Kenji Sugibayashi2007 Volume 22 Issue 4 Pages 458-467
Published: 2007
Released on J-STAGE: October 02, 2007
JOURNAL FREE ACCESS"Cultured skin substitutes" have been developed, and they have already been in practical use in order to widely improve severe burns in recent years due to dramatic advances of tissue engineering. Secondary infection by some bacteria, however, is a possible problem when implanting such skin substitutes. Although protecting the wound skin using skin substitutes is a primary treatment, drug therapies with antibiotic ointments are usually followed. A greater therapeutic effect may be obtained by direct application of the cultured skin substitute containing an antimicrobial substance as a drug formulation on the wound skin. This review introduces the current investigation of dermal patches consisted of cultured skin as a novel DDS for sever skin defects such as severe burns or decubitus.View full abstractDownload PDF (968K) -
Naoya Ohmori, Takeshi Goto, Shuji Sato2007 Volume 22 Issue 4 Pages 468-475
Published: 2007
Released on J-STAGE: October 02, 2007
JOURNAL FREE ACCESSTransdermal vaccines utilizing skin immune function are considered a promising modality to administer vaccines because of their less invasiveness than vaccine administration by injection, of their high safety, and of their simplicity in transport and storage. Furthermore, transdermal vaccines allow the optimization of preparations for each antigen because Th1/Th2 immune responses can be adjusted by skin pretreatment or adjuvant selection. Currently, transdermal vaccine delivery systems (TVDSs) are driven for the optimization of adjuvants and for the development of physical methods to administer antigens. Clinical trials of some systems are ongoing, and TVDSs are now the technologies that are promising also in preventive medicine.View full abstractDownload PDF (826K)
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