We explored genetic polymorphisms in a Thai population which exhibited a low capacity to metabolize coumarin. The following two silent single nucleotide polymorphisms (SNPs) were found:
1) SNP, 020228Kiyotani001; GENE NAME,
CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5′-AAACTACCTGCA
G/TCTGAACACAGAG-3′.
2) SNP, 020228Kiyotani002; GENE NAME,
CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5′-AATCCCCAGCA
C/TTTCCTGAATGAG-3′.
These two mutations (G144A and C1245T), which were located in exon 1 and exon 8 of the
CYP2A6 gene, were found in two subjects among nine poor metabolizers for coumarin.
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