Eleven novel single nucleotide polymorphisms (SNPs) were found in the
NR1I2 (PXR/SXR) gene from 205 Japanese subjects. The detected SNPs were as follows:
1) SNP, MPJ6_1I2001; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-TTTCTACCTCTA
C/TTATTGAAAGGGC-3′
2) SNP, MPJ6_1I2004; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-AGGCCCAAATGT
G/AAGTGATGCATAG-3′
3) SNP, MPJ6_1I2007; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-TGCCAGGCCTGC
C/TGCCTGCGCAAGT-3′
4) SNP, MPJ6_1I2008; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-GAGTGAGCAGTG
G/CGCGCGCGGGCGG-3′
5) SNP, MPJ6_1I2010; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-CAGAGGAGCAGC
G/AGATGATGATCAG-3′
6) SNP, MPJ6_1I2011; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-CTGGAAGTGGCC
A/GGGAGGTTCAAAG-3′
7) SNP, MPJ6_1I2013; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-TCTTCCTCTCGC
C/TCCCAACTTCTGG-3′
8) SNP, MPJ6_1I2017; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-ATTGAATGCAAT
C/TGGCCCCAGCCTG-3′
9) SNP, MPJ6_1I2018; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-GGTGAGCACAGC
A/GGGGGGTGAGGAC-3′
10) SNP, MPJ6_1I2019; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-GAGCTCCGCAGC
A/GTCAATGCTCAGC-3′
11) SNP, MPJ6_1I2021; GENE NAME,
NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5′-GGTGACACCTCC
G/AAGAGGCAGCCAG-3′.
The frequencies were 0.0293 for MPJ6_1I2021, 0.0073 for MPJ6_1I2011, and 0.0024 for the other 9 SNPs. All SNPs were found as heterozygous. Among these SNPs, MPJ6_1I2007, MPJ6_1I2010, MPJ6_1I2017 and MPJ6_1I2019 induce non-synonymous amino acid alterations (R98C, R148Q, R381W and I403V, respectively, in PAR1).
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