Mechanism (s) of the hypocholesteremic action of an anabolic steroid, 2-hydroxymethylene-17α-methyldihydrotesterone (HMD) were investigated in contrast to those of the hypercholesteremic effect of a glucocorticoid, cortisone. HMD or cortisone increased the
in vivo incorporation of acetate-1-
14C into rat liver cholesterol 15 mins. after
14C injection (increased cholesterol biosynthesis) and decreased the incorporation 4 hrs. after
14C injection (increased cholesterol degradation and excretion by the liver). Almost the same results were observed in the intestine. HMD or cortisone also increased the biliary excretion of total
14C and bile acids-
14C after intraperitoneal injection of cholesterol-4-
14C. The fecal excretion of total
14C and bile acids-
14C after cholesterol-4-
14C injection was increased by HMD, on the contrary slightly decreased by cortisone. The gastrointestinal absorption of cholesterol-4-
14C or cholic acid-4-
14C was accelerated by cortisone, while almost no effect was observed by HMD.
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