巻号一覧
18 巻, 4 号
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TAKESHI KUZUYA, YASUNORI KANAZAWA, MITSUAKI HAYASHI, MASATOSHI KIKUCHI ...1971 年 18 巻 4 号 p. 309-320
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーGlucose and xylitol were administered intravenously to man and several mammals in the same doses, and the plasma insulin responses were compared. Marked species differences were found. In man, 12g or 30g of glucose produced definitely greater rises of plasma insulin than xylitol. In cows and goats, both 0.2g/kg glucose and xylitol increased plasma insulin markedly and to a similar extent. Plasma insulin responses of horses to 0.2g/kg glucose and xylitol were rather sluggish and poor. In rabbits, the peak insulin levels following 0.2 g/kg glucose and xylitol were approximately similar or slightly higher after glucose, but with the dose of 1, 0g/kg, the peak plasma insulin value after xylito was a little higher than after glucose. In rats, glucose produced higher insulin peaks than xylitol both at the doses of 0.2g/kg and 1.0g/kg. These results are in contrast to the results obtained in dogs, in which xylitol has a definitely stronger insulin-releasing effect than glucose. The cause for this species variation is not explained at present.抄録全体を表示PDF形式でダウンロード (1167K) -
FUMITOSHI OHNO, KAZUO MIYOSHI1971 年 18 巻 4 号 p. 321-325
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーOver a hundred cases of toxicosis due to weight reducing drugs containing thyroid preparations were recently observed in various areas in Japan. The most frequent cause was the drug “Baset Super” which contains 20mg of Jodocasein and 20mg of desiccated thyroid per tablet. Cases of toxicosis due to weight reducers containing Jodocasein have not previously been reported. The patients had generally been taking 10 to 20 tablets per day for over 6months. In these cases, the chief complaints of the patients were palpitation, emaciation, diarrhea, amenorrhea and psychic abnormalities. A few patients seemed to have an addiction for the thyroid containing drug. In some cases, suppressed state of thyroid and amenorrhea were observed long after discontinuation of the drug.抄録全体を表示PDF形式でダウンロード (816K) -
KAZUTOSHI OKANO, TAKUO FUJITA, HAJIME ORIMO, MASAHIRO OHATA, MASAKI YO ...1971 年 18 巻 4 号 p. 327-333
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーThe activity of enzymes preferentially hydrolyzing parathyroid hormone at pH 8.5 was markedly decreased in the supernatant of rat kidney homogenate centrifuged at 600g 24hr after the intraperitoneal injection of 0.5g/kg Na-Sulfacetylthiazole (SAT). The content of plasma 125I-PTH 30 min after the intravenous injection in SAT-treated rats was greater than that in control animals. The content of 125I-PTH and non-PTHbound 125I was marked ly decreased in the SAT-treated rat kidney as compared with that of controls but there was no difference in the ratio of 125I-PTH to non-PTH-bound 125I in the kidney between SAT-treated rats and control ones. The delayed disappearance of plasma 125I-PTH in SAT-treated rats than in controls might be related to the impairment of inactivation of PTH by the kidney due to the decrease of renal PTH'ase activity induced by SAT treatment.抄録全体を表示PDF形式でダウンロード (781K) -
YOSHIO AIZAWA, HIROSHI KOGO1971 年 18 巻 4 号 p. 335-340
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーThe effect of estradiol on ATPase activity in the rat uterine subcellular fractions and of phospholipid on ATPase activity in the mitochondrial fraction is reported in this paper. Phospholipids used in this investigation were prepared from female rat liver according to the method of Hanahan et al.(1957). 1. The ATPase activity in the mitochondrial fraction was increased by estradiol administration but nuclear and microsomal ATPase activity was not affected by hormone treatment. 2. Phospholipase C treatment of the rat uterine mitochondrial fraction decreased ATPase activity in this fraction. 3. The addition of phospholipid into both intact and phospholipase-treated groups increased ATPase activity in the mitochondrial fraction. These data suggest that phospholipid may be taking part in the increase of ATPase activity after estrogen administration.抄録全体を表示PDF形式でダウンロード (633K) -
YOSHIMASA TASAKA, HISAKO NAKAMURA, MAYOSHI SO, KINORI KOSAKA1971 年 18 巻 4 号 p. 341-345
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーIn order to study the mechanism or insulin release ny xyiitoi ana glucose, in vitro experiments were done in dog pancreas tissue, using the method described by Malaisse et al. Xylitol and glucose in low concentration (60mg/100ml) did not stimulate insulin release above base line values observed in the absence of sugar. High concentration of xylitol and glucose (300mg/100ml) stimulated insulin release significantly, but the amount of insulin released by xylitol was not so much as that by the same concentration of glucose. The insulin-stimulatory effects of glucose and xylitol were inhibited by the addition of epinephrine or propranolol. 2, 4-dinitrophenol blocked them, too. Mannoheptulose inhibited the release of insulin by glucose, but it had no significant effects on xylitol-induced insulin release. These results suggest that xylitol has a direct insulinstimulatory effect in dog pancreas tissue and that there may be a common path in the mechanism of insulin release by xylitol and glucose after it has been metabolized in pancreatic islets.抄録全体を表示PDF形式でダウンロード (577K) -
ARUNA KULSHRESHTHA, C. J. DOMINIC1971 年 18 巻 4 号 p. 347-352
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーThe effect of chlorpromazine (CPZ) on the histology of the hypothalamic neurosecretory system (HNS) was investigated in Suneus murinus L. which were injected with hypertonic saline. Chronic saline treatment brought about characteristic histological changes in the neurons of the paraventricular nucleus (PVN) and depletion of neurosecretory material (NSM) from the cytoplasm, stalk median eminence (SME) and the neural lobe (NL). Acute saline treatment affected the neurons of both the PVN and the supraoptic nucleus (SON); there was no detectable depletion of NSM from SME and NL. Pretreatment with or simultaneous administration of CPZ prevented the appearance of the histological changes in the HNS that normally follow chronic and acute treatments with hypertonic saline. Since the hypertonic saline-induced histological changes in the HNS are regarded as morphological manifestations of increased secretion of the antidiuretic hormone (ADH), the inhibition, by CPZ, of these changes is interpreted as providing histological evidence in favour of the diuretic effect of the drug.抄録全体を表示PDF形式でダウンロード (4093K) -
TOSHIAKI NAKAI, TOMONORI KIGAWA, SHOICHI SAKAMOTO1971 年 18 巻 4 号 p. 353-357
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーMale fetal rats were castrated in utero on the 21st day of pregnancy. Twenty-four hours after the operation, changes of 3H-leucine uptake of hypothalamic nuclei were examined autoradiographically. Leucine uptake in cell bodies of neurons of the arcuate nucleus was enhanced significantly as compared with that in sham-operated control fetuses. However, the uptake in cell bodies of neurons of the supraoptic, paraventricular and ventromedial nuclei did not show any significant change following castration. Since it is known that a gonadotropin releasing factor is a polypeptide and localized to the arcuate nucleus and median eminence, the increase of leucine uptake in cell bodies of the arcuate nucleus seems to suggest the production of a gonadotropin releasing factor as a result of castration. From these findings, it is suggested that the hypothalamic-pituitarytesticular axis begins to function before birth.抄録全体を表示PDF形式でダウンロード (4216K) -
NAGASUMI YAGO, SHIGETAKA SEKIYAMA, HIROMI KUROKAWA, YUKO IWAI, FUMIAKI ...1971 年 18 巻 4 号 p. 359-364
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーBach's theory on sphere size distribution has been applied to the quantitative analysis of changes in the mitochondrial population of the parenchymal cells in the zona fasciculata of the rat adrenal cortex at one hour after a single dose (4 I. U. per head) of ACTH administration. The three-dimensional reconstruction of the mitochondrial population has been performed on the data on diameters of the electron microscopic profiles of the mitochondria sampled at random. The volume for an averaged mitochondrion was 0.617μ3 in the intact control and was significantly increased in the ACTH-injected rats amounting to 0.841μ3. The size distribution histograms for the reconstructed mitochondrial population revealed a shift of mitochondria in the ACTH-injected rats to the larger. These quantitative stereological computations have clearly shown that there is a volume increase in those mitochondria referred to above under the influence of ACTH within one hour. Possible significance of the present findings has been discussed.抄録全体を表示PDF形式でダウンロード (957K) -
SHIGETAKA SEKIYAMA, NAGASUMI YAGO, YUKO IWAI, HIROMI KUROKAWA, FUMIAKI ...1971 年 18 巻 4 号 p. 365-369
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーThe volume fractions and wet weights of the three cortical layers and medulla of the rat adrenal gland have been quantitatively determined by the stereological volumetry on the histological photograph during the period of 3days following hypophysectomy. Both of the volume fraction and wet weight decreased significantly only in the zona fasciculata after hypophysectomy. The mitochondria in the parenchymal cells of the zona fasciculata have been reconstructed three-dimensionally by Bach's theory on sphere size distribution. The total number of the mitochondria in the unit cytoplasmic volume and the average values of their radius and volume have been computed. The size distribution histograms have also been obtained in terms of the relative frequency as a function of the mitochondrial radius. These quantitative stereological computations have offered the evidences that 1) there is a volume increase in the zona fasciculata mitochondria following hypophysectomy, and 2) the total number of the mitochondria in an individual rat decreased to the half in about 3days.抄録全体を表示PDF形式でダウンロード (660K) -
MOTOAKI KOSUGIYAMA, JUNICHI MORI, HIROSHI NAGASAWA1971 年 18 巻 4 号 p. 371-374
発行日: 1971年
公開日: 2011/01/25
ジャーナル フリーThe antiserum against mouse growth hormone (MGH) was produced by immunizing monkeys and some basic immunological properties of the antiserum were studied.
The antiserum formed single precipitin lines in agar gel double diffusion plate against both MGH preparation and the crude extract of mouse anterior pituitaries, but reacted with neither normal mouse serum nor the crude extracts of several viscera of mouse. Immunoelectrophoresis of the antiserum with MGH preparation showed a single precipitin arc at the corresponding site of MGH. The precipitin lines between MGH preparation and monkey antiserum and rabbit antiserum to MGH produced previously by us fused completely. Furthermore, the biological activity of MGH was significantly inhibited by the antiserum. All the results have demonstrated that the antiserum obtained in the present experiment contains the antibody specific only to MGH.
The cross-reaction test of the antiserum indicates that MGH shares immunologically reactive site identical to that contained in growth hormones of rats, rabbits, goats and cows.抄録全体を表示PDF形式でダウンロード (5640K)
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