Esophageal manometric studies were carried out using an endoscope, which is useful for diagnosis and patho physiology in esophageal disorders. Esophageal peristalsis was measured by means of a direct transducer (Figure 1). Lower esophageal sphincter pressure (LESP) was measured by a rapid pullthrough technique with a PE catheter of 1.7 mm in internal diame ter constantly infused with water at a rate of 2.0 ml/min.. A forward-viewing fiberscope was introduced into the esophagus only with surface anesthesia of pharynx. After introduction of an endoscope, esophageal peristalsis were elicited by the stimulus of air which was sent by a simplified constant pressure device (Machida) connected with an air inlet of the endoscope and measured by a direct transducer inserted through a channel orifice of the endoscope (Figure 2). For measurement of LESP, a tip of the endoscope was placed at about 5 cm proximal to the gastroesophageal mucosal junction and a manometric tube was inserted in a similar way. Manometric study of esophageal peristalsis was per. formed on 98 subjects which consisted of 5 groups as shown in Table 1. Esophageal peristaltic waves were successfully recorded in all cases of group A (control subjects) at the part of 10 cm proximal from the gastroesophageal junction. Mean frequency, amplitnde, andduration of the peristaltic wave were 4.6±0.9 number/min., 37.8±15.6 cm H2O, 1.9±0.8 second respectively. In group B (PSS), frequency and amplitude of the peristaltic wave were significantly lower than those of control subjects (P<0.001, Figure 14), (P<0.05, Figure 15), and 18 of 35 cases showed aperistalsis, 7 cases showed weakness of the peristaltic wave. The detection rate of esophageal changes in PSS was 71.4% by the manometric method in comparison with 57.1% by only radiography (Table 2). In the other groups, 2 cases of dermatomyositis, 3 cases of achalasia, 1 case of esophageal carcinoma, and another of gastric polyp (72 year old, female) showed abnormalities of the peristaltic waves. The LESP was measured in 23 control subjects, 12 patients with PSS, 6 patients with hiatal hernia, and 3 patients with achalasia, the mean LESP were 16.3±5.8, 7.8±4.3, 8.7±6.5, 26.2±6.3 mm Hg respectively. The LESP in PSS was significantly lower than that of control subjects (P<0.001, Figure 20).
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