Abstract
We studied efficacy and safety of a low-dose sedative in eshophagogastroduodenoscopy.
Subjects and methods
We intravenously administered midazolam as a sedative. We measured SpO
2, blood pressure and pulse rate and also observed subjective symptoms during the procedure. Doses of the agent per body surface area were divided into four groups : group A, less than 1.5 mg/m
2 ; B, 1.5 to less than 2.0 ; C, 2.0 or more ; and D, no agent.
Results
There were no significant difference in SpO
2 reduction and changes in blood pressure and pulse rate. An increment in Rate Pressure Product (RPP), an index of myocardial oxygen consumption, did not differ significantly among patients in terms of the above parameters. (t-test) Vomiting reflexes at the time of endoscope insertion or during the examination were significantly suppressed by the agent depending on its dose (
x2 test p<.01). Significantly more patients answered “the examination was easy” in the agent users than in the non-users (
x2 test p<.001).
Conclusion
Conscious sedation using a small dose of the sedative made the endoscopic examination safe and easy.
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