Background:Although pure ethanol injection therapy (EI) for hemastasis of pepticulcer is highly effective, little is known about its complications especially secondary ulcerinduced by EI (EI ulcer). The aim of this study is to assess the frequency, positive rebatingfactor, and prognosis of EI ulcer.
Methods: 225 patients with hemorrhagic gastric ulcer were treated with EI in ourhospital in the past five years. Pure ethanol 0.1-0.2ml was injected on each shot aroundand on the exposed vessel until the vessel profile is destroyed. The procedures were carriedout on serial days until the vessel profile is vanished. Primary ulcer factors and procedurefactors were analyzed in relation with EI ulcer. Mann-Whitney U test was used forstatistical analysis.
Results:Rebleeding rate was 13% (29/225) . Six cases (3%) needed operation becauseof unsuccessful hemostasis with EI. Complete hemostasis rate was 97%. EI ulcer was seenin 35%(78/225) . Following factors had a positive relation with larger El ulcer; large or deep Primary ulcer (P=0.02), large or middle sized exposed vesse1 (P=0.02), centrallylocated exposed vessel (P=0.01), many EI counts (P=0.0001), and bleeding Provoked by EI (p=0.0003) .
About three months (average) needed for large EI ulcer to heal.
Conclusions: Larger or deeper gastric ulcers have tendency to bleed with EI, and withthese that have larger exposed vessels, centrally located expased vessels, and/or these whoneed (many) (numbers of) EI injections, have tendency to make larger EI ulcers.
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