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Norio TANI, Tetsu NOMIYAMA, Takeshi MIWA
1982 Volume 24 Issue 12 Pages
1853-1859
Published: December 20, 1982
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It was investigated whether the local administration of dibutyryl cyclic AMP induced acid secretion or not by endoscopic congo-red test using three mongrel dogs under anesthesia. After equal application of 0.3% congo-red solution in the stomach following enough lavage by 3% sodium bicarbonate solution 0.3 ml of 50 mg/ml dibutyryl cyclic AMP solution was injected into the mucosa of lesser culvature of the body with the exclusive injector under endoscopy. Spotty discoloration was observed near the point of injection, where a small mucosal elevation was formed just like intradermal injection, about 10 min. after the injection. And then discolorated area gradually spread out around the point of injection, but it did not spread out all the secreting area. These phenomenon were also observed in case the vagus was restrained by administration of atropin sulfate (0.05 mg/kg, i. m.) and in case the H
2-receptor was blocked by administration of cimetidine (6 mg/kg, i. v.). The local injection of physiological saline solution, distilled water, 20% glucose, 50 mg/ml dibutyryl cyclic GMP solution didnot induce the discoloration. After all the fact that exogenous cyclic AMP inuduce gastric acid secretion was observed under endoscopy by using congo-red test. This may support the second messenger concept for cyclic AMP in acid secretion from parietal cells.
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Keishi TAKECHI, Junichi OKUDA, Kazunori IDA, Takeo NAGAYO
1982 Volume 24 Issue 12 Pages
1861-1865_1
Published: December 20, 1982
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Five cases of fundic gland polyposis (FGP) were examined with dye spraying endoscopy. One of the five cases was associated with ademomatosis of the colon. Characteristic endoscopic views of FGP were as follows: 1) Polyps were distributed in the upper part to lower part of the gastric body. These polyps were multiple (10-100 in number), measuring up to 8 mm in the greatest diameter. Most of these polyps looked sessile with a smooth surface, but closed view of them revealed uneven surface. And some of them seemed to be a pile of several small polyps. 2) The gastric mucosa surrounding polyps was covered with fine area gastricae indicating absense of atrophic gastritis or intestinal metaplasia. Longitudinal linear redness, indicative of superficial gastritis, was observed at several sites of the antrum. 3) The mucosal border of the stomach with FGP was of closed type.
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Yohei FUKUMOTO, Takahiro KODAMA, Yoshinori NUMA, Takaro ESAKI, Masatak ...
1982 Volume 24 Issue 12 Pages
1866-1873_1
Published: December 20, 1982
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In order to evaluate the relationship between laparoscopic features and histological findings of the liver in patients with chronic active hepatitis in whom hepatic disorders progressed in a short period, the changes of liver surface were evaluated in patients whose findings of liver histologi were aggravated at repeated examination. Subjects were 16 patients with chronic active hepatitis, of whom 10 had repeated liver biopsies under laparoscopy, and the remaining six had both blind biopsy and biopsy under direct view through laparoscopy. The mean follow-up period from the 1st to 2nd examination was 20 months. In addition to the macroscopical changes, such as irregularity and nodular formation on the liver surface, fine laparoscopic observations also gave us more reliable markers which suggested possible progression of tissue damage. These markers were that is increased numbers of small vessels, star and/or mesh like reddish marking, reddish patchy marking and many small depressions. Moreover, nodules were visualized sporadically, in the early stage of nodular liver of B type viral chronic heatitis. Therefore, it might be possible to predict laparoscopically the progression of chronic acitive hepatitis, if the appearance of these markers is revealed on the liver surface through the clinical course.
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Sei TOMATSU, Itaru OI, Fumitake TOKI
1982 Volume 24 Issue 12 Pages
1875-1881
Published: December 20, 1982
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Two cases in which small spots were demonstrated around the terminal common bile duct on endoscopic retrograde cholangiogram were reported in this paper. Case 1: A 26 year-old man complained of epigastralgia and left back pain. Chronic pancreatitis was diagnosed and small spots around the terminal common bile duct were shown on endoscopic retrograde cholangiopancreatogram. Case 2 : A 70 year-old-man complained of a right hypochondralgia. Gallstones were detected in the gallbladder and dilated bile duct, and small spots were shown around the terminal common bile duct on endoscopic retrograde cholangiogram. This would be the first report of visualization of small spots around the terminal common bile duct on cholangiogram, which are considered to be the dilated sacculi of Beale that consist of mucous glands.
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Hiroyuki HANAI, Eizo KANEKO, Fumitoshi WATANABE, Junichi KUMAGAI, Mits ...
1982 Volume 24 Issue 12 Pages
1882-1891
Published: December 20, 1982
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From October 1976 to September 1981, the authors performed 3, 000 proctosigmoidoscopic examination to 2, 794 outpatients. They were divided into 2 categories as follows. 1) Ones who had symptoms suggestive of the lower intestinal tract disorders. 2) Ones who had digestive disorders other than the intestinal tracts or ones to whom the proctosigmoidoscopy were undertaken as a routine preoperative examination. Pathological findings were found in 466 cases of the total patients (16.7 %) by proctosigmoidoscopy, including 105 cases of carcinoma (3.8%), 227 cases of benign polypoid lesions (8.1%) and 134 cases of inflammatory disorders (4.8%). Among 105 colorectal carcinoma, 26 cases were early carcinoma and 79 were advanced carcinoma and among 227 benign polypoid lesions, adenomatous polyps were 118 cases. Average age of the patients with adenomatous polyp and carcinoma were 58.2 and 63.6 years respectively. Both malignant and benign polypoid lesions were apt to be found in the right side colon among older people. Lesions found by proctosigmoidoscopy covered 33.1% of adenoma, 76.5% of early carcinoma and 58.5% of advanced carcinoma in the lesions of the total colon. The incidence of adenoma and carcinoma in the total outpatients (51, 209) in the periods were 0.23% and 0.21% respectively. In conclusion, routine examination of the proctosigmoidoscopy to the outpatients is very effective as the screening method of colorectal carcinoma.
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Hiroyuki HANAI, Eizo KANEKO, Fumitoshi WATANABE, Junichi KUMAGAI, Mits ...
1982 Volume 24 Issue 12 Pages
1892-1899
Published: December 20, 1982
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The occult blood testing of stool in the diagnosis of the colorectal lesions were evaluated with the results of the routine proctosigmoidoscopy and guaiac slide test. The patients were divided to the following 2 groups : 1) Ones who had symptoms suggestive of the lower intestinal tract disorders. 2) Ones who had digestive disorders other than the intestinal tracts or ones to whom the proctosigmoidoscopy were undertaken as a routine preoperative examination. Guaiac slide tests (Shionogi Test) were performed Once for each patient (1968 cases) and 2500 cases including all these cases were undertaken protosigmoidoscopy. The rate of positive occult blood testing were 38.5% of mucosal carcinoma, 54.5% of submucosal invading carcinoma, 93.2% of advanced carcinoma and 37.5% of adenoma. These results suggest that single guaiac slide test is insufficient for detecting colorectal carcinoma and the false negative rate for them is 40.2% as a whole.
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Tsuyoshi AIBE, Tadasu FUJI, Fumio ASAGAMI, Hideo AMANO, Masao KAWASHIM ...
1982 Volume 24 Issue 12 Pages
1900-1909
Published: December 20, 1982
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Following the 1st. and the 2nd. type of the ultrasonic endoscope (U. E.), the 3rd. type was developed by the Olympus Co. and the Aloka Co.. We had been investigating the clinical availability of the U. E. (Type 1, Type 2 and Type 3) and the examined cases became 38 cases in total. In this paper, we reported the details of our experience with the 3rd. type of the U. E.. The results were as follows. 1) The endoscopic echograms of the pancreas were more clear than the transcutaneous echograms of the pancreas in details. 2) The U. E. was very useful in visualization of the pancreatic tail which could not been visualized clearly by the transcutaneous echography. 3) The common bile duct could be visualized by scanning at the duodenal bulb and the 2nd. portion of the duodenum. 4) In 6 of 10 cases, we succeeded in inserting the U. E. into the 2nd. portion of the duodenum and we could obtain the echogram of the head and the uncus of the pancreas. 5) The 5 layers of the gastric wall were visualized and the depth of the invasion of the gastric cancer could be diagnosed by the U. E. (Type 3). Then, the submucosal tumor of the stomach was visualized easily by the U. E.. As the conclusion, we confirmed that the 3rd. type of the U. E. would be useful in the further examination of the pancreatobiliary disease and the gastric disease.
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Nobuyoshi OISHI, Tatsuo YAMAKAWA, Takashi MIYOSHI, Kunihiro HIROSAWA, ...
1982 Volume 24 Issue 12 Pages
1910-1916
Published: December 20, 1982
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Experience with postoperative choledochoscopy using the Olympus CHF type 4B was analyzed in this paper. The Olympus CHF type 4B, 670 mm in length, has a 330 mm flexible part at the distal end. The short distal tip, 5.0 mm in diameter, deflcets 160° upward and 90° downward. This improvement has overcome not only the limitation of visula field compared with that of conventional choledochofiberscope, but also makes it easier to insert choledochofiberscope into the biliary tract through the dilated PTCD sinus tract. A basket forceps used with this fiberscope is considered to be strong enough to grasp and extract the stones, but development of several kinds of thinner forceps such as crushing forceps which can be used through the irrigation channel, 2 mm in diameter, is strongly expected. It is considered that the Olympus CHF type 4B is a very useful tool for management of retained biliary tract stones and intrahepatic stones.
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Yozo IIDA, Ken TAKEUCHI, Hajime HARADA, Masahiro TADA, Masayuki YAMAGU ...
1982 Volume 24 Issue 12 Pages
1917-1925_1
Published: December 20, 1982
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It is well known that histamine H
2 receptor antagonist is very effective as an anti-ulcer agent. New H2-blocker, ranitidine which shows marked inhibition of gastric secretion, has been developed in recent years. This time, 46 cases with gastric ulcer were treated with ranitidine and endoscopic features in these cases were studied. Unusual endoscopic findings were noted at the healing stage of the ulcers among ranitidine-treated ulcers, such as shallow white coat, protrusion in ulcer floor and so on. These unusual ulcers were named "specific healing group". On the other hand, usual healing process, treated with conventional drugs, was named "ordinary healing group". At this moment, comparative studies between specific healing group (16 cases) and ordinary healing group (30 cases) were done from various view points. Histological studies of biopsy specimens, taken from ulcer floor protrusion at healing stage, proved granulation tissue with slight epithelial regeneration. The period from active stage to healing stage in specific healing group is seemed to be shorter than in ordinary healing group. We concluded that ranitidine had marked repairment effect on early stage of ulcer, independent on size of ulcer, site of ulcer, gastric secretion and plasma gastrin level. Unusual findings in specific healing group ; protrusion in ulcer floor, is seemed to be due to the early regeneration effect of ranitidine.
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Tomosumi IKEDA, Issei SENOUE, Masafumi HARA, Sohtaro SUZUKI, Shigeru H ...
1982 Volume 24 Issue 12 Pages
1927-1935
Published: December 20, 1982
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There have been several reports suggesting a relationship between pernicious anemia and carcinoid tumor of the stomach. This paper reports on the occurrence of gastric polyposis with carcinoid tumor and type A gastritis which often leads to pernicious anemia. A 49 y. o. Japanese male, under medical observation for gastric polyposis for 10 years, was admitted to our hospital because the biopsy from one of these polyps was diagnosed as carcinoid tumor. Physical examination and laboratory studies were all negative except for moderately elevated gastrin level (570 pg/ml), a positive test for parietal cell antibody (PCA) and markedly reduced acid secretion (MAO : 0.20 mEq/hr). Radiologic and endoscopic examination of the stomach showed polyposis in the body but not in the antrum. Argyrophilic carcinoid tumor was located on the greater curvature of the upper body and was removed by wedge resection. Endoscopic Congo-red test showed blue-black changes only on the top of some polyps while methylene-blue test showed dye absorption only on the mucosa surrounding these polyps and on the fornical mucosa. Endoscopic biopsy revealed an increased number of argyrophilic cells in the fundic mucosa with G cell hyperplasia in the antral mucosa. Oxyntic glands were well preserved on the top of the polyps in contrast to the atrophic mucosa around the polyps. Hence, a relationship is suggested between type A gastritis and gastric carcinoid tumor. The polyposis can be properly called as "pseudopolyposis" duo to the atrophic changes by the type A gastritis.
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Masafumi HARA, Yutaka TSUTSUMI, Keiichi WATANABE, Sohtaro SUZUKI, Nori ...
1982 Volume 24 Issue 12 Pages
1936-1941_1
Published: December 20, 1982
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Endocrine cells in a gastric polyp, which was removed by endoscopic polypectomy, were immunohistochemically investigated. Patient was 48 y. o male. The pedunculated polyp was located at the fornix of the stomach. Endoscopic congo red test revealed that the polyp was found in the oxyntic gland area and contained acid-secreting parts in itself. Endoscopically removed polyp was 13 × 11 × 9 mm in size and was histologically diagnosed as hamartomatous polyp, mainly consisting of numerous cystically dilated fundic glands. In order to elucidate the endocrinological background of the polyp, immunohistological studies on gastrin, somatostatin, glucagon and glicentin were performed by the immunoperoxidase method. Pronounced hyperplasia of somatostatin-containing cells and the presence of glucagon and glicentin-containing cells were demonstrated among the cystic component of the polyp, while gastrin-containing cells were absent. Our findings suggest that endocrine cells proliferate as a hamartomatous element, and that the polyp carries a character of fetal fundic mucosa, for gastric glucagon in man has been detected exclusively in the fetal gastric fundus. Since no immunohistochemical studies on gastrointestinal hormones in gastric polyps has been reported so far, the present work may contribute to the investigations on cell kinetics and pathogenesis of gastric polyp.
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Sakuko ISOBE, Hiroaki SASAKI, Kimie KUROKAWA
1982 Volume 24 Issue 12 Pages
1942-1947_1
Published: December 20, 1982
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This paper deals with a case of duodenal tuberculosis encountered recently. The patient was a 26 year-old man who had undergone appendectomy and radical treatment of anal fistula. He had pulmonary tuberculosis with a cavity in the upper lung field. Tubercle bacilli were cultured in the sptum. Two weeks after hospitalization, he developed epigastric pain and postprandial vomiting, X-ray an upper gastrointestinal series revealed a marked annular stenosis in the descending part of the duodenum. Endoscopically, the papilla of Vater was observed in the lesion. X-ray examination of the large intestine revealed widespread tuberculous lesion from the ileocecal region to the transverse colon. He was treated conservatively with antituberculous drugs and his clinical course was uneventful. In order to investigate changes in the incidence of duodenal tuberculosis due to wide-spread use of chemotherapy, a comparison was made between cases developing before 1955 and those after 1955 through a review of the literatures. It was found that after 1955 duodenal tuberculosis also occurred in elderly patients, being located in the anal side of the papilla of Vater or horizontal part.
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Taeko MIYAHARA, Kiyoshi FUJITA, Takashi HARIMA, Yoshihito UCHIDA, Hiro ...
1982 Volume 24 Issue 12 Pages
1948-1959
Published: December 20, 1982
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Four cases of Crohn's disease involving the large bowel (two definite and two probable cases of Crohn's disease) are studied with special reference to the characteristics on X-ray findings and endoscopic findings. In one of the probable cases, longitudinal ulcer was found at the transverse colon during the clinincal course. In one of the definite cases, clinical manifestations have fulfilled the clinical standards of Crohn's disease one by one during the clinical course. In the rest of the cases, X-ray and endoscopic findings have revealed no change from their onsets. We think it is inappropriate to make the diagnosis of Crohn's disease at the first medical examination. Therefore, if we come upon any cases of inflammatory or infectious bowel disease, we should give our mind to Crohn's disease and observe the X-ray and endoscopic findings for a long time.
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Tatsuo MUNEHISA, Ryosaku HARADA, Hiroshi TEZUKA, Keisuke NAKATA, Akihi ...
1982 Volume 24 Issue 12 Pages
1960-1965
Published: December 20, 1982
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A case of acquired double pylorus complicated with systemic lupus erythematosus is described. The patient is a 50-year-old female. Upper gastrointestinal series and fiber-scopic examination by means of so-called U-turn technique with a small caliber panendo-scope in the duodenal cap confirmed a pylorus consisting of two opennings deviled by a septum. Double pylorus in this patient appears to be due to a pyloroduodenal fistula caused by penetration of a prepyloric ulcer into the duodenum.
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1982 Volume 24 Issue 12 Pages
1966-1967
Published: December 20, 1982
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1982 Volume 24 Issue 12 Pages
1968-1969
Published: December 20, 1982
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1982 Volume 24 Issue 12 Pages
1970-1973
Published: December 20, 1982
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1982 Volume 24 Issue 12 Pages
1974-1976
Published: December 20, 1982
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1982 Volume 24 Issue 12 Pages
1976-1978
Published: December 20, 1982
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1982 Volume 24 Issue 12 Pages
1979-2051
Published: December 20, 1982
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1982 Volume 24 Issue 12 Pages
2052-2070
Published: December 20, 1982
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