Acase of lack of expression of C-KIT in gastrointestinal stromal tumor (GIST)of thestomach is reported. A-83-year old man was admitted to the our hospital because of right transcervical fracture.He had had Iight-headness and been diagnosed anemia and hypotension by another clinic. Afteradmission, he complained of tarry stood. Endoscopic examination reveled blood clot with ulceration an the suhmucosal tumor in thebody. After treatment with conservative therapy, but he complained of continual tarry stoolswith progression of anemia. Then we performed partial gastrectomy. A histological examina-tion of the resected tumor showed mainly diffuse spindle cells proliferation. In spindle tumorcells, immunohistochemical analysis reveled positive for CD34 and vimentin of mesenchymalmarker, negative for smooth muscle actin, 5-100, desmin, Factor VIII and C-KIT protein.Furthermore molecular analysis of c-kit gene reveled no abnormalities. The diagnosis of GISTof the stomach, uncommitted type vvas made. FIST constitute the largest category of mesenchymal neoplasia of the alimentary tract.There are many immunohistochemical studies that have been carried out by numerous mvesti-gators. This has resulted in a considerable degree of confusion in tumor lacking differentiationand either cell imrnunohistochemical phenotyping, it's termed FIST, uncommitted type.Recently, C-KIT protein overexpression have been found in almost GIST with uncommittedtype. In this case is histologically typical GIST, but no immunoreactivity of C-KIT protein. Wediscussed the characteristics of our case in comparison to category of GIST, uncommitted type.
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