The continual administration of Bleomycin (BLM), as has beem observed, can bring on fibroplastic alteration in mouse pulmonary tissue. In the enzyme-induced mouse by phenobarbital, on the other hand, rather increased activity and reduced pyrexia have been observed. Observations were done on the distribution of cortisol in the vital organs of mice in continual BLM-administration: the ones with preceding phenobarbital treatment and those without such treatment. Following are the results of the comparison between the data for the above-mentioned mice and the data for the control group.
1) The BLM-administrated mice had tissues alteration suggesting pulmonary fibroplastic phenomena.
2) Continuing high concentrations of cortisol in the tissues were observed in the BLMadministrated mice.
3) The aspects of the distributions of cortisol in the tissue of mice with preceding phenobarbital treatment were similar to the data for the control group.
These results suggest that fibrosis of the lung by BLM can be prevented by enzymeinduction.

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Two cases of Cornelia de Lange syndrome with cleft palate were presented.
This syndrome is charactarized by severe mental retardation, anomalies of the extremities and charactaristic faces.
This syndrome also is occasionaly accompanied by cleft palate.
Detailed descriptions as to oral manifestations in the reported cases were also made.

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Only Virchow (1879) reported a case concerning simple bone cyst in 1879. Since Lucas (1929) was the first writer on the region of oral surgery, there have beenmany reports of this lesion in literature. Simple bone cyst is a cystic disease which is rare in jawbones. On the jawbone, the most common location of the disease is the mandible between the canine and ramus.
We experienced two cases of simple bone cyst.
Case 1: 12-year-old male.
Chief complaint: Swelling of median mandibular.
History of the present illness: 4 years ago, the Pt was struck at the median mandibular by other person's head, but he made favorable progrcs's without symptoms.
Electrical vitality test; 4321234 was vital.
Roentgenogram: An orthopanoramic radiography showed a simple cystic lesion with well defined sclerotic margins at the apical area of 321123 tooth.
Treatment: Extirpation of cyst and marsupialization.
Histopathologic diagnosis; Thin connective tissue menbrane lining the cavity.
Case 2: 32-year-old male.
Chief complaint: Swelling at mandibular region.
History of the present illness: 18 years ago, the Pt was struck in a sporting accident and suffered a bruise on the mandibular bone, But made favorable progress without symptoms.
Electrical vitality test: 4321234 was vital.
Roentgenogram: An orthpanoramic radiography showed a simple cystic lesion at the apical area of 321123 tooth.
Treatment: Extirpation of cyst.
Histopathologic diagnosis: Thin connective tissue menbrane lining the cavity.

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In this paper, a 16 year old male case of odontogenic myxofibroma with peculiar calcareous substances in the lower left molar region and mandibular ramus was reported. He had suffered from a swelling without pain in this region. Radiographic examination revealed a multilocular and radiolucent lesion containing a mandibular third molar and uncertain cloudy radiopaque shadows. Boundary of the lesion was radiographically comparatively clear. Extraction of the second molar and removal of the tumor were performed under general anesthesia. The tumor was 6.5×3. 5×4.0cm in size, trancelucent and light brown color, smooth surfaced with soft consistency and cystic lumens containing viscoid fluid.
Thin calcareous substances were scattered in the tumor.
Microscopically, the tumor consisted of dense fibrous connective and myxomatous tissues. Tumor cells were stellate or spindle shaped, but mitotic figure was not seen. The tumor contained numerous peculiar calcareous substances which varied in size and were of unknown origin. The tumor was diagnosed odontogenic myxofibroma because of the existence of epithelial islands of odontogenic origin and continuation between dental sac of the embedded third molar and tumor tissue. No recurring after treatment.

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Sialolithiasis is common in major salivary glands and ducts, but sialolithiasis of minor salivary glands seems to be rather rare as judged by the small number of publications on this subject.
A case of sialolithiasis of minor salivary glands in the right upper lip of a 24-year-old woman is presented.
The purpose of this study is to review the information presented in the 10 previously reported cases of minor salivary gland lithiasis in Japan and to add the information gained from this case.

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The simple bone cyst has been termed as traumatic bone cyst, hemorrhagic bone cyst, solitary bone cyst, and progressive bone cavity. The lesions occur most often in long bones and rarely in jaws. The cause of simple bone cyst is unknown, but numerous theories that it occurs from trauma or local disturbance of bone growth et al have been proposed.
A rare case of large simple bone cyst in a man of 16 years is presented. The patient was referred for evaluation and treatment of swelling in the right side of the mandible. There were buccal and lingual bone expansion in the right mandible. Radiographically, there was a well defined multilocular radiolucent area extending from 2 to 8 tooth-germ that had a very characteristic scalloped appearance between the roots of the right molar teeth.
The lesion was a space in the bone that the mandibular vessel and nerve were exposed freely within the cavity. Histologically, the cavity was lined by a thin fibous connective tissue membrane and had no epithelial lining. This patient had a history of trauma to the mandible when 7-8 years old.

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Nowadays, facial trauma is getting much more complicated and severed along with the social factors.
Progress in surgical, anesthetical and medical ambulatory care has made it possible to save severely injured patients. Such life-threatening forces also cause severe facial trauma and cases needing more complex treatment plans arc increasing.
In this paper, a case of a 44 year old male treated with multiple reconstructive procedures is presented.
The patient was caught in to an iron-work machine by his left forearm and had an abulsed right malar area. After first aid for life was given, he was transfered to our department. The extent of injury was confirmed to be a rt. cheek full-thichness defect, partial loss and fractures of maxilla and mandible, multiple facial lacerations and burns through the first operation included wound debridement and primary maxillary and mandiblar reduction and fixation.
One month later, the facial defect settled to 6 × 9 cm and segmental loss of rt. mandible was evident. D-P flap and forehead island flap reconstruction for cheek defect, mandibular repair with Vitallium^® cast splint and iliac bone graft, transposition of parotid duct to oropharynx were performed.
Through 4 separate operations over 20 hours, good functional and cosmetic reconstruction was aquired.

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Gingival fibromatosis is generally regarded as a disease that leads to an extensively diffuse and remarkable hyperplasia of the maxillo-mandibular gingiva.
Recently, we encountered a comparative rare case of gingival fiblomatosis accompanied by marked enlarging masses in the right maxillo-mandibular gingiva. The patient, a 21-yearold female, had been aware of a diffuse hyperplasia in right the maxillo-mandibular gingiva for about 2 years. As the lesion had increased remarkably as nodular masses, she was referred to our hospital.
The patient's parents were cousins. Except for her elder sister, there was no family history of gingival firomatosis. Thus, the influence of hereditary factors in our patient was obscure.
Based on clinical and histopathological findings, the unilateral remarkable phymatoid gingival hyperplasia was considered to be caused by gingival fibromatosis with inflammatory hypertrophy.
Under general anesthesia, gingivectomy was performed without extraction of teeth. The postoperative course was satisfactory.
After the operative wound had healed she was given instructions in tooth brushing. To date, 4 years and 6 months after operation there has been no occurrence.

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Malignant melanoma will be rarely found in the oral cavity, and the disease seemed to be easily diagnosed because of the characteristic pigmentation. On the other hand, there are some difficult cases of the amelanotic type to make a differential diagnosis from other neoplasma correctly because of their rare occurrence and lack of pigmentation.
Therefore, these tumors are apt to be easily resected without confirmation when diagnosis was made by clinical findings alone. According to these reasons, it is generally accepted that the prognosis of amelanotic type of malignant melanoma is rather poor, compared with the melanotic type of malignant melanoma.
A male patient, 67 years old, was found to have a bumpy nodule in his upper gum 6 months ago, prior to his first hospital.visit. The nodule increased gradually, and showed some bleeding tendency during tooth brushing. He was examined by a dentist and the nodule was immediately resected without precise diagnosis. Within 2 months after surgery, however, the tumor reappeared.
Physical examination revealed that the nodule was 15×12mm in size, pinkish color and peduncolated, which was shown by the partial errosion in the tumor. The tumor was characterized by elastic soft consistency and revealed a bleeding tendency, but had neither ulcer nor pigmentation at all. The X-ray examination revealed that pathological resorption of alveolar bony structure was absent. The palpated regional lymph nodes were within normal limits. Since the surgical excision of a wide tumor area has been performed, he has been followed up carefully and periodically in our out-patient clinic.
Six months later, although no changes were recognized in the primary site, the left submandibular lymph nodes were observed to grow gradually.
He was suspected to have metastasis of the lymph nodes in the submandibular region, which were not extended to other distant body parts. This was confirmed by the whole body scintigraphy, using 67Ga and 99mTc. A radical neck dissection was performed and there were a lot of metastases, whose histopathological analysis have demonstrated the affected regional lymph nodes. After the surgical procedure, he received adjuvant immunochemotherapy. The protocols of combined chemotherapy were as follows:(1) OK-432, 5.0 KE twice a week, (2) Pepleomycin 10mg, ACNU 100mg and VCR 1mg weekly and (3) DTIC 100mg, ACNU 100mg and VCR 1mg weekly. The protocols of (2) and (3) have been applied on the patient for 1 week of medication time, which did have 3 weeks of pausing duration in-between. This procedure of (2) has been repeated 3 times and that of (3) has been repeated 2 times during the hospital course. That of (1) has been applied every 3 days. After all procedures were finished, he was discharged without finding of recurrence or metastasis of tumor. However, 6 months later on a regular check-up, an X-ray examination of the chest revealed a suspicious shadow of metastasis and recurrence was found at the left cervical. Immediately, radiotherapy was performed and the tumor was regressed but another metastasis appeared in the chest and increased in both size and number and then he died of pneumonitis.

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Varix is a vascular lesion in which the veins of an area are permanently dilated and tortuous. It occurs most often in the veins of the lower limb and the esophagus.
Report of varix in oral region is rare.
We experienced three cases of varix occuring in oral cavity, and reported on them. The first case was a 61 year-old female in whom varix occured in the right mandibular gingiva. The second case was a 30 year-old female with a varix in the left sublingual region. The third case was a 73 year-old male arising in the right side of the tongue.
Each case was seen clinically as a firm, dark purple, uneven nodule, and histopathologically as the dilation of the veins and thrombus formation.

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It is well known that von Willebrand's disease (v. Wd) is a coagulation disorder caused by the insufficient activity of von Willebrand factor (VIIIR: WF) which is associated with factor VIII related antigen (VIIIR: AG). This disease is inherited as a autosomal dominant trait. Three familial patients of classical v. Wd were admitted and received surgical treatments. The summaries of the respective cases were as follows:
Case I: Mother, 46-year-old, showed severe hemorrhagic diathetic tendency; bleeding time (BT) is longer than 15 min, platelet adhesiveness (PA) is lower than 6%, restocetin-induced platelet aggregation (RIPA) is 19%, factor VIII activity (VIII: C) is 26.5%, VIIIR: AG is 15% and VIIIR.: WF is lower than 6%. With the transfusion of a commercial cryoprecipitate preparation (AHF 200 unit), numerous extractions of decayed teeth (642 13456 8 5678) and enucications of radicular cysts (4 456 5) were carried out. Hcmostasis after the operation was performcd by both the additional administration twice of AHF (200 unit) and the application of the splint.
Case II: Daughter, 14-year-old. The results of blood examination were: BT> 15 min, PA 10%, RIPA 3%, VIII: C 20%, VIIIR: AG 17.5% and VIIIR: WF<5%. She received AHF (200 unit) and was extracted (6 6). No bleeding occurred after the extraction.
Case III: Daughter, 12-year-old. BT>15 min, PA 12%, RIPA 53%, VIII: C 18.5%, VIIIR: AG 15% and VIIIR: WF<6% After the scaling of tooth stone, gingival bleeding could not be controlled by pressing; however, hemostasis was obtained by elcctro-eoagulation.
On case I and H, time course examinations of VIIIR: AG, VIII: C, VIII R: WF, RIPA and BT were carried out. From factors examined in vitro and clinical courses the followings were confirmed: RIPA was a more satisfactory marker than VIIIR: WF and BT for the clinical bemostatie conditions were more correlated with RIPA, and the relation between kinetics of VIII: C and BT after the AHF transfusion and the clinical course were not evident. Additionally, it may be also mentioned that numerous tooth extraction at a time was more advantageous by considering the improvement in RIPA and other factors by AHF than the only few teeth extraction.

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The case was a 47-year-old man, having a recurrent squamous cell carcinoma of the right cheek.
A bilateral neck dissection was performed on the patient. After en-block excission of the full thickness right cheek and right mandible, the defects were reconstructed with a deltopectoral skin flap (D-P flap) proposed by Bakamjian in 1965. A simple ipsilateral D-P flap was employed, and neither lining of the split thickness skin graft nor the other flap was used.
The result was satisfactory, cosmetically and functionally. A D-P flap is versatile, facile and reliable, but the disadvantage is necessity of two operations.

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Solitary neurofibroma in the oral cavity is rare. We have reported a solitary neurofibroma occurred on the tongue, which is first such reported in Japan.
A 33-year-old woman visited our clinic with a main complaint of swelling of the left undersurface of tongue. The swelling was primarily red bean size, but it enlarged to thumb size for one year. We didn't find cafe-au-lait spots nor tumors on the skin of her whole body. The tumor was excised and was relatively circumscribed but non encapsulated. Pathological diagnosis was neurofibroma.
Electron microscopic findings are also discussed.

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We saw a patient who had multiple jaw cysts of deaf-mutism with a cleft lip and cleft jaw, and had several examinations on suspicion of a basal cell nevus syndrome.
The patient, an 18-year-old woman was first seen at the First Department of Oral Surgery, Fukuoka Dental College, because of swelling in labial gingiva of the region from the left mandibular canine to the right mandibular canine. Roentgenographic examinations disclosed cystic radiolucencies in maxilla and mandible.
Further, general examination revealed frontal bossing, a broad nasal root, hypertelorism, right heterochromie, numerous pigmental spots at the left neck, palmar and plantar pits in both palms, scoliosis and scoliokyphosis.
Endocrinal and chromosomal examination showed nothing particular.
Cysts were enucleated and their histopathological diagnoses were odontogenic keratocyst.
She had satisfactory prognosis without relapse. We think it necessary to have a long term follow-up.

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Two sisters suffering from Glanzmann's thrombasthenia required extraction of decayed permanent teeth. This report describes the etiology and diagnosis of thrombasthenia, and reviews the literature concerning tooth extraction, with an emphasis on hemostatic procedures including platelet transfusion and local management.

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Eosinophilic granuloma is thought to be a type of histiocitosis together with Hand-Schiiller-Christian and Letterer-Siwe disease. The oral lesion is relatively rare, but cases of its occurring in the mandible and soft tissues arc reported.
The outline of our case is as follows: An 18-year-old male visited the dental office because of teeth mobility associated with pain in a left mandibular molar. The patient was treated with antibiotics for several days but symptoms continued, and was referred to the Gunma University Medical School on Feb. 25, 1980 for further treatment.
The patient's general health was satisfactory. Oral manifestations revealed swelling of the check and mandibular arca, as well as gingival swelling with mobility of the 1st and 2nd premolar and 1st molar. Roentgenogram suggested ameloblastoma of the mandible but biopsy results showed it to be a bony eosinophilic granuloma. Full body radiograms were examined but indicated no abnormalities; so a diagnosis of solitary eosinophilic granuloma was made.
The patient was prevented to conic to the hospital because of a fractured fibla. During this delay the radiolucent defect in the mandible enlarged to involve the left coronoid and condylar process, and extended to the right mandibular canine.
Hemimandiblectomy was followed by an immediate reconstruction of the mandible using a Bowerman-Conroy titanium implant on Oct. 28, 1980.
The lesion was too extensive to preserve the mandible. During the operation the body and ramus section of the implant were fixed together for shaping the left side of the jaw bone. This implant was fixed to the mandible utilizing two nuts and sleeved bolts, and the condylar portion was spaced 1 cm. from the articular fossa.
Three and a half years after the operation the prognosis is favorable, and the patient is pleased esthetically, and also satisfied with his mandibular movement and his ability to masticate.

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Clinical and liistopathological studies of four patients with ostcosarcoma of the jaws were reported.
1. Three patients were female and one was male, and their age ranged from 30 to 64 years.
2. One case had the lesion in the maxilla and the other in the mandible. Three cases with mandibular sarcoma complained of painless swelling, and one with maxillar sarcoma complained of paresthesia.
3. After the operation, three cases recurred, two of which showed metastasis.
4. Two of the patients had been diagnosed as osteosarcoma by preoperative biopsies but in the other two cases, malignancies were not found and fibrous dysplasia and ossifying fibroma were diagnosed respectively.
5. Examinations of the resected specimens revealed that the proliferative pattern of osteosarcoma was different depending on the area of the lesion. Central area was occupied with mature fibrous tissue and bone. Intermediate area was characterized by malignant osteoid and various features such as fibrosarcoma and benign tumorous lesion. In the marginal area, malignancy was not always found and extensive search seemed necessary for a correct diagnosis.
Accordingly, it seemed important to take a biopsy specimen not only from the marginal edges but also from the deeper area.

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Dentofacial deformity of myotonic dystrophy is long face, open bite, high arch palate and V shaped dental arch of the maxilla. In such a case, it is necessary for the meticulous evaluation of deformities to correct these conditions simultaneously.
In this report, the authors present a case of myotonic dystrophy associated with dentofacial deformity and the method of preoperative evaluation, especially about model surgery with the Whip-Mix articulator.
The authors' surgical procedure under these conditions is total maxillary alveolar ostcotomy advocated by Walford and Epkcr with segmental osteotomy and sagittal spliting osteotomy of the mandibular rami. We think these procedures are versatile and stable for the long face associated with the high arch palate.

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Fibrous dysplasia is a benign fibro-osseous lesion of unkown etilogy. It is said that it may affect only a single bone (monostotic), or it may be present in, two or more bones (polyostotic). The disease is generally encountered in childhood or early adulthood. It grows very slowly. We recently experienced a case where this disease broke out in the right craniofacial region. A patient, a 63-year-old woman, complained of swelling in the right mandibular body at our hospital on February 25, 1983. Under the diagnosis of fibrous dysplasia, an incision was made from the second premolar to the second molar. The mucoperiosteal flap was retracted and the exposed buccal bone removed. The area was curetted, and the flap was returned and sutured in place. The histo-pathological examination of the specimens showed findings of fibrous dysplasia. Fourteen months have passed since the operation and the prognosis is favorable without any relapse tendency.

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Malignant lymphoma is a neoplasm of lymphoid tissue. Although its favorite site is the head and neck, it occurs, though rarely, in the oral and maxillofacial regionas well.
A biopsy of tumor of the head and neck is a principal clue for diagnosis of malignant lymphoma. Once a biopsy diagnosis for malignancy has been established, it is important to undertake a search for all sites of involvement, using a combination of clinical, roentgenographic, laboratory and surgical techniques. After treatment has begun, clinicians should be conscious of patterns of response to treatment, acute morbidity associated with radiotherapy and chemotherapy, and major complications that may result from these forms of treatment.
This report includes two cases of malignant lymphoma in the oral and maxillofacial region.
Case 1: A 39-year-old woman complained of ulceration on the left buccal gingiva of the molar teeth, and noticed paresthesia of the left lower lip. Enlargement of the lymphnodes of the submandibular, cervical, axillary and inguinal regions could not be detected. Biopsy of the region of ulcer, the cervical vaginal portion and the bone marrow, and other examinations established the diagnosis for non-Hodgkin's lymphoma, diffuse lymphoma, mixed type, stage IV B. Though treated effectively with CHOP, she died of shock two months after appearance of the first symptoms.
Case 2: A 77-year-old woman noticed three months prior to the first visit that her left submandibular region had swollen without pain. This lesion was about 7×4 cm and immobile, and suspected to be a tumor of the submandibular salivary gland. Biopsy and other examinations were performed which showed non-Hodgkin's lymphoma, diffuse lymphoma, medium cell type, stage I A. She was treated with chemotherapy (COPP) and radiotherapy (total dose 50 Gy) to the upper part of the left side of the neck. After the treatment, suprahyoid neck dissection was performed. Histopathologically, no evidence of malignancy was found. The postoperative course was uneventful, and there has been no sign of recurrence of the tumor or of metastasis to other organs since discharge.

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In this paper, we reported a case of odontogcnic keratocyst extending from the mandibular premolar of right side to the ramus of maclible.
The patient, a 51-year-old male, visited our hospital complaining of swelling of 8 position. The face had slight unsymmetry.
In oral cavity findings, redness, swelling and tenderness of buccal guns of 8-5 position, pluriorificium of gingiva of 8 7 position, yellow-brown excretion accompa.tied by stench were noted.
In radiological findings, from near 5 position to the ramus of mandible, a monoloculor shadow with clear border was observed.
Based on medical examination of mandibular cyst, we operated exploratory excision with fenestration, and obtained a pathological diagnosis of odontogcnic hyperkeratocyst. Thus, we planned to do iliac autotransplantation with total extirpation and curettage, and underwent operation.
In finding, after extraction, the cyst had a size was 55×40×25mm, covered with a smooth and elastic hard outer surface, and the inside of the cyst that had white or yellow-brown color was covered with a tissue having one robust layer.
In pathological and histological findings, the cyst walls composed of some stratified squamous epitheliums and encapsulation layer. Inside the cyst had a typical histological picture of the odontogenic keratocyst covered with hyperkeratosis stratified squamous epitheliums.
In the first, we intended to perform jaw resection, however, because of remaining bone of lingual side and quick atrophy of the cyst with fenestration, we decided to perform total extirpation. Prognosis was favorable, but as recurrent of this symptom is high, we planed to continue to observe prognsosis carefully.

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Twenty-one cases of mandibular fracture were treated by A. O. Osteosynthesis. The main advantage of this method is to eliminate or shorten the term of intermaxillary fixation for immobilization of the stump of the mandible. Although intermaxillary fixation alone is usually applied for 4 to 6 weeks, the average time of intermaxillary fixation in this series was 9.5 days.
Application of the A. O. Plate was performed principally by extra-oral approach, but in the anterior and premolar area it was able to be carried out by intra-oral approach.
Though paralysis of a marginal branch of the facial nerve occured in one case, it disappeared 6 months postoperatively.
Though paralysis of a marginal branch of the facial nerve occured in one case, it disappeared 6 months postoperatively.
The major shortcomming of this osteosynthesis, i. e., occurrence of postoperative malocclusion was overcome as follows: arch bar splints were constructed individually on the plaster models taken from each patient, rigid intermaxillary ligation was applied during the operation before the osteosynthetic procedure, and fixation was continued for approximately one week after the operation.
Precise incision along the skin fold followed by meticulous closure of the wound resulted in aesthetically highly favorable wound healing and minimal scar formation.

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The nasal-vestibular cyst, or nasoalveolar cyst, is infrequently observed face lesion. We removed the cyst from the left nasal alar region of a woman aged 71 who had been afflicted with the lesion for the previous 4 years. The cyst was as large as a pigeon's egg.
The patient had been aware of the swelling over the left ala of the nose for the past 4 years. For the past two months the patient had been unable to wear her upper denture because of the swelling involving the superior labial fold area.
An obvious asymmetry of the left side of the face was noted. The swelling was about 4 cm in diameter, nontender, soft and fluctant and was located over the left piriform aperture of the nose and extended into the left nasal cavity to some degree. Approximately 15ml of cloudy somewhat brownish fluid was removed and immediately replaced by a same amount of 76% Urografin^® contrast medium. The roentgenograms revealed a well-defined, oval cystic cavity situated in the soft tissues of the face at the junction of the upper lip and the lateral wall of the left nostril. The cystic cavity was disclosed to be entirely within the soft tissues and lying very close to the anterior surface of the maxilla.
Microscopic examination revealed a cyst lined by a few layers of cuboidal cells. These cells appeared to be squamous but might be pseudostratified columnar cells containing goblet cells.
Comparative study of 31 cases of nasal-vestibular cyst that had been reported in the dental literature of this country from 1960 to 1980 was made, and the clinical features and differential diagnosis of the disease were discussed.

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Chcrubism in a six-year-old Japanese girl is presented. The patient demonstrated painless swelling in the right angle region of the mandible at age three years, and swelling appeared in the left at the age of four. Radiographic examinations of the mandible revealed bilateral multilocular areas of increased radiolucency, loss of the tooth germs of the bilateral second molars and absorption of the distal roots of the bilateral first molars. Histopathological diagnosis of the lesion was giant cell granuloma of the jawbone. Familial examinations showed that her father had a bilateral and symmetrical bone protrusion in the frontal region.

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In the field of oral surgery, since symptoms appear in and around the oral cavity, tube feeding is frequently carried out for nutritional control. Natural foods such as ‘Omoyu’ and milk or enteral nutrients containing lactose have been used as enteral feeding diets used for the tube feeding form of old. These enteral nutritional products have such weak points as causing side effects including putrefaction, diarrhea and vomiting or as being not able to sufficiently control the nutritional state for a long time. Ensure Liquid, an enteral nutrient, does not contain lactose in order to prevent diarrhea clue to lactose intolerance. Further, by the use of solid corn syrup and sucrose, the product is synthesized to have a low osmotic pressure so that it can prevent the appearance of hypertonic diarrhea. In the present study, comparison was made between Ensure Liquid and conventional liquid diets, mainly natural foods, both of which were given to patients treated in the clinic of oral surgery, with respect to die controlled nutritional state and side effects. It has been confirmed that Ensure Liquid is a superior product.

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