日本口腔外科学会雑誌
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
44 巻 , 1 号
選択された号の論文の22件中1~22を表示しています
  • 榊 敏男, 和唐 雅博, 田村 功, 虫本 浩三, 白数 力也, 田中 昭男, 榊 鉄也
    1998 年 44 巻 1 号 p. 1-10
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Intercellular adhesion of epithelial tissue is mainly regulated by the E-cadherin (E-CD) molecule.α-Catenin (α-CAT) is an E-CD associated cytoplasmic protein that forms a linkage to the cytoskeleton and regulates E-CD function. To investigate the relationship between the expression of E-CD and α-CAT as well as the expression of both adhesion molecules and histopathological features, we immunohistochemically and biochemically studied E-CD and α-CAT expression in 62 biopsy specimens of primary oral squamous cell carcinoma. Both adhesion molecules were expressed homogeneously with typical membranous staining at cell-cell borders in normal oral epithelium.
    The reduction (or loss) of E-CD expression was 38.7%, and that of α-CAT was 71.0% in oral cancers. The expression of α-CAT closely correlated with that of E-CD in many cancers, but the reduction (or loss) of α-CAT expression was greater than that of E-CD expression in some. Regarding histopathological features, the reduction (or loss) of α-CAT expression more closely correlated with cancer differentiation and invasion than did that of ECD expression in human oral squamous cell carcinomas.
    These results suggest that both E-CD and α-CAT are important regulators of intercellular adhesion and that α-CAT is also involved in tumor differentiation and invasiveness.
  • 立石 晃, 三瀬 恒太郎, 村木 祐孝, 古田 治彦, 吉岡 泉, 曽我部 浩一, 安元 信也, 福田 仁一
    1998 年 44 巻 1 号 p. 11-15
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    The purpose of this study was to identify prognostic factors in patients with stage I and II oral squamous cell carcinoma who underwent surgical treatment. Sixty-six patients with newly diagnosed, stage I and II oral squamous cell carcinoma who underwent operation at the First Department of Oral and Maxillofacial Surgery, Kyushu Dental College hospital between 1985 and 1994 were retrospectively analyzed. The clinical factors studied were tumor location, method of excision, prophylactic neck dissection, and method of treatment. The pathological factors studied in biopsy materials were the degree of the differentiation, vessel invasion, tumor depth, YK-classification, and histological malignancy grading as defined by Anneroth (1987). The results are summarized below.
    (1) The 5-year cumulative survival rate was 86.8% in stage I and 83.2% in stage II. Nine patients had local recurrence, 3 had postoperative regional lymph node metastasis, and 1 had postoperative distant metastasis. In 11 of these 13 patients (84.6%), symptoms occurred within 14 months.
    (2) The local recurrence rate (13.6%, 9/66) was relativery high. However, the rate of regional lymph node metastasis (4.5%, 3/66) was low.
    (3) Local recurrence occurred in patients who underwent mandibular marginal resection and had stage II disease, a tumor depth of ≥ 4 mm, and a YK-classification of 4 C or 4 D. There was a significant correlation between outcome and the histological malignancy grade of Anneroth (1987)(step-wise method).
  • 河野 峰, 柴田 敏之, 永易 裕樹, 北所 弘行, 中田 大地, 有末 眞
    1998 年 44 巻 1 号 p. 16-21
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    We studied whether epidermal growth factor (EGF) enhances the motility of human oral squamous cell carcinoma (SCC) cells in an autocrine manner. The motility of five SCC cell lines (SAS, Ca 9-22, HSC-2, -3, -4) was examined with the use of a phagokinetic track assay. The motility of SAS cells and HSC-2 cells was significantly increased without EGF stimulation as compared with the three other cell lines. Amounts of EGF in the culture supernatants of the five cell lines after 48h of culture were examined with the immunoblotting method. EGF was detected in the supernatants of SAS cells and HSC-2 cells (SAS, 8.65±0.45; HSC-2, 2.60±1.13ng/ml). SAS cells, showing the highest levels of motility and EGF production, was used for further study. When SAS cells were treated with anti-EGF antibody, anti-EGF receptor antibody, and erbstatin analog, the motility of SAS cells was significantly inhibited. Furthermore, the culture supernatant of SAS cells enhanced the motility of HSC-3 cells in a concentration-dependent fashion. These results suggest that EGF may stimulate the motility of human oral SCC cells in an autocrine manner.
  • 石井 興
    1998 年 44 巻 1 号 p. 22-29
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    In the present study, the effects of progesterone on fusion of the secondary palate were examined in vitro.
    Methods: The maxillary region of A/J mouse fetuses (13.5 days) was dissected and cultured in a chemically-defined serum-free medium for 72 hours. Progesterone was added to the culture medium in a concentration of 0.1, 1.0, or 10μg/ml.
    Results: 1) Among 22 explants in the vehicle-control group, the palatal shelves completely fused in 10 (46%). The palatal shelves fused partially in 6 explants, contacted but did not fuse in 4, and failed to contact in 2.
    2) In the group treated with 0.1μg/ml progesterone (n=21), complete fusion occurred in 13 explants (62%) and partial fusion in 7 (33%). The palatal shelves contacted but did not fuse in 1 explant, and failed to contact in no explant.
    3) When treated with 1.0μg/ml progesterone (n=22), the palatal shelves fused completely in 21 explants (95%) and partially in 1 (5%). None of the cultured palates failed to fuse.
    4) When the palatal explants were cultured with 10μg/ml progesterone (n=20), the palatal shelves fused completely in all explants. The complete fusion rate was significantly higher in the 1.0μg/ml and 10μg/ml groups than in the control group.
    5) Head length, head width, and palate length were greater in all progesterone-treated groups than in the control group.
  • 園田 悟
    1998 年 44 巻 1 号 p. 30-41
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    The purpose of this study was to quantitatively evaluate inflammation in the temporomandibular joint (TMJ) by means of dynamic magnetic resonance imaging (MRI) in patients with TMJ arthrosis.
    Dynamic MRI was performed with a SPGR pulse sequence (TR, 35 ms; TE, 8 ms; flip angle, 60°) before and after administration of Gd-DTPA (0.1 mmol/kg). Signal intensity (SI) in the ROI was calculated in the region of the posterior disk attachment. The signal intensity ratio (SIR) at t minutes after Gd-DTPA administration was calculated by the following equation: SIR (t)={SI (t)-SI (pre)}/S1 (pre). The average SIR at 3.5, 4, 4.5, and 5 minutes was defined as the signal enhanced score (SES).
    1. To clarify the characteristics of dynamic MRI of the TMJ, a time-SIR curve was plotted every 30 seconds from just after until 8.5 minutes after Gd-DTPA administration in 20 painful and 28 painless TMJs. Painful TMJs had significantly higher SIR values than painless TMJs at all times. The time-SIR curves became stable 3.5 minutes after Gd-DTPA administration in both groups.
    2. Joint cavity pumping with a local anesthetic was performed after dynamic MRI in 42 painful TMJs. It proved that 31 TMJs had pain within the joint.
    3. As an index for distinguishing the group with pain within the joint (31 TMJs) from the normal TMJ group (32 TMJs), SES was most useful, and its discriminant value was 0.87.
    4. Analysis using this discriminant point (SES=0.87) revealed a significant difference between 189 painless and 167 painful TMJs.
    5. Among 52 painless TMJs with SES values over 0.87, 48 had painful TMJ on the opposite side. Thus, patients with unilateral painful TMJ may have inflammation in the opposite TMJ, even if it is asymptomatic.
    6. In 192 TMJs with SES values over 0.87, there was a positive correlation between pain and SES, suggesting that SES can be used as an index of morbidity and therapeutic efficacy. The results show that dynamic MRI is a useful, noninvasive method to diagnose inflammation within the TMJ.
  • 福田 幸泰
    1998 年 44 巻 1 号 p. 42-51
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Many bone substitutes have been used for oral and maxillofacial surgery. Use of the best material for the patient is critical to clinical success. In this study, osteoblastic cells established from the calvaria of newborn C57BL/6 mice were used to examine osteocompatibility in terms of cell adhesion, cell proliferation, and calcification with materials.
    Bio-glass ‹BG›(SiO2, 46.1%; Na2O, 24.2%; CaO, 26.9%; P2O2, 2.6%), hydroxyapatite sintered at 1300°C‹HT›, 1100°C ‹MT›, and 900°C‹LT›, single crystal alumina ‹S-AL›, poly-crystal alumina ‹P-AL›, zirconia ‹ZrO2›, titanium ‹Ti›, titanium alloy ‹Ti-alloy›(Ti-6 AL-4V), and nickel-titanium alloy ‹TiNi›(50Ti-50Ni) were used for this study. A piece of petri dish was prepared as control for these materials. The total surface area(1cm2) and surface roughness(Rmax<3μm) of each material was the same.
    Cell adhesion was examined by the centrifugal method. After centrifugation(1610g×20minloading), cell adhesion rates were calculated. Cell proliferation was quantified by the Lowrymethod as the amount of protein synthesized on each material. Cell calcification poten-tial was measured on the basis of alkaline phosphatase activity by means of the Bessey-Lowry method.
    Cell adhesion was high on S-AL, P-AL, ZrO2, Ti, and Ti-alloy. Cell proliferation was high on BG, MT, and LT. Cell calcification potential was high on BG, MT, and LT. Our results indicate that compatibility at the cellular level is an important factor in the clinical application of dental implants and bone substitutes.
  • 高田 真仁, 芳澤 享子, 野村 務, 新垣 晋, 中島 民雄
    1998 年 44 巻 1 号 p. 52-54
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    We report the results of a clinical study of 14 patients with oral carcinoma who were over 80 years of age. This group accounted for 11.3% of 124 patients with oral carcinoma who we treated between 1985 and 1995. The patients consisted of 4 men and 10 women with a mean age of 82.9 years. Tumors were most commonly located in the tongue (5 cases) and gingiva (5 cases), followed by the buccal mucosa (3 cases) and floor of the mouth (1 case). Clinically, 8 patients had early-stage carcinomas. Histologically, there were 11 squamous cell carcinomas, 1 verrucous carcinoma, 1 mucoepidermoid carcinoma, and 1 spindle cell carcinoma. The main treatment was surgery in 7 patients and radiotherapy in 5 patients. The 2 other patients received only chemotherapy. Nine patients died of uncontrolled disease. The 1-year, 3-year, and 5-year survival rates calculated by the Kaplan-Meiermethod were 57.1%, 50.0%, and 27.8%, respectively. The outcome was not good in inoperable patients with advanced tumor.
  • 君塚 哲, 越後 成志, 福井 功政, 田中 謙一, 伊藤 正健, 飯塚 芳夫
    1998 年 44 巻 1 号 p. 55-57
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Two patients with squamous cell carcinoma of the lower lip underwent immediate reconstruction by the modified Fries method. Patient 1 was a 93-year-old woman with T2N0M0. Patient 2 was a 79-year-old woman with T1N0M0. The Fries method is a technique for reconstruction of the lower lip region with a bilateral buccal flap. This method results in symmetrical facial features after operation. We improved this method as described below to create a red region of the lower lip. First, the skin of the red region of the lower lip was excised, and the adjacent oral mucosa was ablated and reduced. The reduced mucosa was sutured at the margin of the excised skin. This procedure facilitates the reconstruction of the red region of the lower lip, as compared with the Fries method. Both patients had good function and an esthetical appearance of the lower lip region after operation.
  • 熱田 藤雄, 加藤 治郎, 横江 秀隆, 宮 恒男, 丹沢 秀樹, 佐藤 研一
    1998 年 44 巻 1 号 p. 58-60
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Recently, reports of fungal infection have increased, but coexistence of fungal infection with carcinoma in the paranasal sinus is very rare except in compromised hosts, and only one case has been reported in the literature.
    A 60-year-old woman was referred to our clinic because of a mild pain around the right infraorbital region. She had suffered from asthma for the past 30 years and used prednisolone for at least 8 years.
    X-ray examination revealed a ball-like radiopaque lesion in the upper medial part of the right maxillary sinus with partial destruction of the remainder. Biopsy specimens showed a fungal mass in the former lesion and carcinoma in the latter.
    Treatment included FAR therapy and right maxillary hemisection. The postoperative course has been uneventful for 6 years. The definite bacteriological and histopathological diagnosis was fungal infection due to Penicillium monoverticillate with moderately differentiated squamous cell carcinoma in the right maxilla.
  • 足立 雅利, 吉野 暁, 柳井 智恵, 白川 正順, 野中 博子
    1998 年 44 巻 1 号 p. 61-63
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    We describe a patient in whom pleomorphic adenoma developed on the lower lip. A 65-year-old woman presented to this department with a chief complaint of swelling of the right portion of the lower lip. She had noticed this abnormality approximately 1 and a half years ago.
    There are only a limited number of reports describing of pleomorphic adenoma of the lips, especially pleomorphic adenoma arising in the lower lip.
    Surgical excision has been often used to treat pleomorphic adenoma of the lips. Surgical therapy, however, requires long-term follow-up because postoperative relapse and aggravation have been reported occasionally. Fortunately, the patient made good postoperative progress, and the long-term outcome has been favorable, with no recurrence.
  • 小川 淳, 福田 喜安, 藤沢 完爾, 小野寺 政雄, 武田 泰典, 工藤 啓吾
    1998 年 44 巻 1 号 p. 64-66
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Pleomorphic adenoma has the highest incidence of all salivary gland tumors. However, this tumor rarely develops in the sublingual gland. We describe a patient with a pleomorphic adenoma in the left sublingual gland. A 27-year-old woman noticed a painless swelling in the left sublingual gland and visited our hospital for in-depth examination after about 2 months. A well-delineated mass with a smooth surface (20×10mm) was noted in the left sublingual gland. This mass was elastic, hard, and movable but not tender. Since biopsy confirmed the presence of a pleomorphic adenoma, the tumor was resected under local anesthesia. The resected tumor (20×30mm) adhered to the inferior surface of the sublingual gland. The tumor tissue, which was completely covered by a fibrous capsule, was concavoconvex and lobular (20×30mm). Histological examination also showed features of pleomorphic adenoma.
  • 吉田 雅志, 高久 逞, 佐野 次夫, 今井 謙一郎, 友利 浩一郎, 松田 雅明
    1998 年 44 巻 1 号 p. 67-69
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Recently, we encountered a rare case of odontoameloblastoma that developed in the mandibular angle region.
    The patient was a 35-year-old woman who was initially brought to our department because of a swelling on the right side of the mandibular angle region. On examination her general condition was good, and there were no abnormal findings. At the lesion, swelling was localized to the right side of the mandibular angle. On palpation, the lesion felt like a hemispheric protrusion of bone. Radiograhic examination showed a unilocular radiolucent lesion, associated with an irregular intralesional radiopacity.
    The clinical diagnosis was a bone cyst with a calcified body in the mandibular angle region. The bone cyst was totally extirpated under general anesthesia. The tumor, which consisted of solid tissue, measured 17 × 16×16 mm and was surrourded by a capsule. The histopathological diagnosis was odontoameloblastoma.
  • 神出 敏影, 古賀 賢三郎, 木下 基司, 斎藤 輝海, 外山 正彦, 高橋 洋平
    1998 年 44 巻 1 号 p. 70-72
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Myoepithelioma is a rare tumor (incidence less than 1 % of all salivary gland tumors). We report a case of myoepithelioma of the hard palate.
    A 15-year-old man complained of a painless mass on the palate. There was a wellcircumscribed swelling, measuring 25mm in diameter, on the hard palate. It was dark blue and had an elastic soft consistency. Sagittal magnetic resonance images revealed on oval mass with iso-intensity on T 1-weighted images and medium high intensity on T 2-weighted images. The mass pressed the hard palate toward the nasal cavity, but a sheet of bone intervened between the mass and the nasal floor. The preoperative histopathological diagnosis, based on examination of an incisional biopsy specimen, was monomorphic adenoma.
    With the patient under general anesthesia, the tumor was removed subperiosteally with a 5-mm safety margin of mucosa. The osseous palate was hollow, but there was no bone destruction. It was therefore not resected. The tumor was 20mm in diameter and surrounded by a thin fibrous membrane.
    Microscopically, the tumor consisted of plasmacytoid and spindle-shaped cells with round eccentric nuclei surrounded by abundant homogenous eosinophilic cytoplasm in a fibrous stroma.
    Immunohistochemical studies revealed positive reactions for cytokeratin, vimentin, and S100 protein in the tumor cells.
    Finally, the postoperative histopathological diagnosis was myoepithelioma (combination of plasmacytoid and spindle-shaped cells).
    Wound healing was good, and there was no evidence of recurrence as of 3 years after the operation.
  • 真野 隆充, 上山 吉哉, 大山 和彦, 岸本 晃治, 栗坂 成年, 松村 智弘
    1998 年 44 巻 1 号 p. 73-75
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    We report a case of eosinophilic granuloma in the maxilla, mandible, and temporal bone of a 21-year-old man. Resorption of the maxilla was accidently found on radiologic examination, and a histological diagnosis of eosinophilic granuloma was obtained on examination of a biopsy specimen. The lesion of the temporal bone was enhanced by Tc scintigraphy. Surgical therapy was therefore performed for each lesion.
    After 7 months, the lesion at the temporal bone recurred, and a new lesion appeared at the mandible; radiation therapy was therefore performed.
    After treatment the patient's course has been good, and there has been no recurrence for 15 months.
  • 佐藤 仁, 福田 喜安, 泉沢 充, 大屋 高徳, 工藤 啓吾, 武田 泰典
    1998 年 44 巻 1 号 p. 76-78
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    In the oral region, dermoid and epidermoid cysts usually occur in the floor of the mouth and rarely arise in other sites. We report a very rare case of epidermoid cyst in the pterygomandibular space.
    The patient was a 67-year-old man who was referred for examination of an asymptomatic swelling in the right oropharynx. MRI revealed a multilocular cystic lesion in the pterygomandibular space. The clinical diagnosis was a cyst, and the lesion was enucleated by an intraoral approach with the patient under general anesthesia. Histopathologically, the cyst wall was lined by a thin layer of keratinizing squamous epithelium and fibrous connective tissue with no skin appendages. It was diagnosed as an epidermoid cyst.
  • 加納 康行, 額田 純一郎, 中西 千草, 太田 嘉幸, 道澤 雅裕, 松本 理基, 田村 啓史, 末松 基生, 作田 正義
    1998 年 44 巻 1 号 p. 79-81
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    A clinicostatistical study was performed in Seventy-three children who had suffered oral and maxillofacial soft tissue injury with no hard tissue injury. Seventy-three children were classified into four developmental stages. The developmental stages were infancy (0-1 years old), preschool age (1-6 years old), school age (6-12 years old), and adolescense (12-16 years old).
    Seventy-eight percent of the children were infants or preschool age. The ratio of boys to girls was 1: 1 in infancy, 2: 1 in preschool age, 8: 1 in school age, and 6: 1 in adolescence. Accidents during preschool age occurred primarily in the evening and night, but accidents during infantcy happened at all times. Falls were the most frequent cause of injury during infancy and preschool age. In school age and adolescense, some injuries were caused by blows and sports, similar to adults. The most frequent locations of soft tissue injury in infants were the tongue and frenulum of the upper lip. In preschool age, the most frequent sites of injury were the palate and tongue. In school age and adolescence, the most frequent site was the facial skin.
  • 中野 靖子, 小林 恒, 佐藤 寿, 中山 勝憲, 成田 明子, 木村 博人
    1998 年 44 巻 1 号 p. 82-84
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    We report a case of bilateral ankylosis of the temporomandibular joint (TMJ) that occurred after streptococcal infection. The patient was a 30-year-old man, whose initial symptoms were fever and polyarthritis including the TMJ. He was treated by his orthopedist for a diagnosis of streptococcal infection, and chronic polyarthralgia resolved. However, 3 and a half years later, he visited our clinic because of difficulty in mouth opening. The clinical course and radiographic findings indicated a diagnosis of bilateral TMJ ankylosis caused by poststreptococcal arthritis. We subsequently performed TMJ mobilization.
    Histological examination of the left condyle showed that the articular cartilage was edematous with multiple sites of cystic absorption and that the fibrotic bone marrow involved osteoblast-like cells. Examination of the right condyle showed a thick layer of fibrocartilage and extensive proliferation of granulation tissue involving elastic fibers and necrotic bone cartilage. IL-6 and TNF a were detected in concentrations of 0.406 pg/mg and 0.103 pg/mg by ELISA in the specimen of the right condyle.
    These findings suggest that TMJ ankylosis in this patient was caused by injury of bone and chondrocartridge matrices affected by poststreptococcal arthritis. The destruction of TMJ components might have been induced by inflammatory cytokines.
  • 石井 宏昭, 清水 一, 笠原 英生, 佐々木 眞一, 郷家 久道, 瀬戸 皖一
    1998 年 44 巻 1 号 p. 85-87
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    This paper describes our experience with a case of hyperplasia of the unilateral mandibular coronoid process.
    The patient was a 25-year-old man. At the age of about 17 years, he realized he had lockjaw but did not do anything about it. Panoramic radiography revealed marked hyperplasia of the right mandibular coronoid process.
    Coronoidectomy was performed by an intraoral apploach. As of 2 years after the operation, the mouth can be opened 40mm and jaw movement is normal on magnetic resonance imaging.
  • 窪田 強, 植田 章夫, 福屋 武則, 小松 史, 千野 武廣, 武井 則之
    1998 年 44 巻 1 号 p. 88-90
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    Aspergillosis of the paranasal sinuses is considered relatively rare. In this report, we describe a case of aspergillosis of the maxillary sinus.
    The patient, a 73-year-old woman, visited our department because of nasal obstruction on the left side. X-ray examination revealed diffuse radiopacity in the left maxillary sinus. The clinical diagnosis was left odontogenic maxillary sinusitis, and the Caldwell-Luc operation was performed conventionally. Histopathological examination of surgical specimens revealed the presence of aspergillus.
    Follow-up examination up to 3 years 5 months after the operation showed no recurrence of symptoms, and the patient's course has been good.
  • 毛利 謙三, 永原 國央, 松岡 俊光, 津田 勝一, 久保田 崇, 兼松 宣武
    1998 年 44 巻 1 号 p. 91-93
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    A case of maxillary antrolith caused by a fungus ball in a 45-year-old woman is presented. Computed tomography showed a calcified mass in the right maxillary sinus. The clinical diagnosis was right maxillary sinusitis. The patient was treated surgically. The calculi were postoperatively examined by HE Staining, PAS staining, von Kossa staining, and EPMA analysis.
    The calculi were PAS-positive; the margin of the calculi was von Kossa-positive, and other regions were von Kossa-negative. Calcium was detected by EPMA of the margin of the calculi.
  • 白井 泰彦, 別所 和久, 東條 格, 松本 隆司, 飯塚 忠彦
    1998 年 44 巻 1 号 p. 94-96
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    TERMEAL®2.0 provides 2 kcal per 1 ml, which allows a high amount of energy to be obtained in a small quantity.
    We gave TERMEAL®2.0 to 30 patients who underwent oral surgery, and evaluated the usefulness of this product. After treatment, nutritional status, evaluated on the basis of total protein, albumin, and total cholesterol levels, improved as compared with before TERMEAL®2.0 treatment. There was no significant difference in side effects between TERMEAL®2.0 and several other transintestinal nutritional supplements. We conclude that TERMEAL®2.0 is useful in patients undergoing oral and maxillofacial surgery.
  • 後藤 昌昭, 香月 武, 井原 功一郎, 豊田 純一朗, 竹下 文隆, 奥村 晃
    1998 年 44 巻 1 号 p. 97-99
    発行日: 1998/01/20
    公開日: 2011/07/25
    ジャーナル フリー
    We histomorphologically analyzed the interface between grafted bone and titanium implants in retrieved en-bloc material. The patient had squamous cell carcinoma of the maxilla at the left molar region. Maxillary sinus augmentation of the right side was carried out with an autogenous iliac bone graft at the time of partial maxillectomy. Implants were placed secondarily. Clinically, however, osseointegration was not completed. Histologically, the grafted bone was not in contact with the implant, and fibrous connective tissues were observed at the bone-implant interface. Irradiation and chemotherapy before surgery may have prevented remodeling of the grafted bone and osseointegration.
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