Twenty-seven primary oral and soft palate squamous cell carcinomas were examinedto classify the degree of malignancy according to the volume corrected mitotic (M/V) index, and the relationship between the degree of malignancy and outcome was studied. The following results were obtained:
1.In terms of the relationship of the M/V index to the 5-year cumulative survival rate, group I (<10 mitoses/mm
2), group II (≥10 to <20), and group In (≥ 20) had a survival rate of 100.0%(P<0.001), 77.8%(P<0.05), and 25.0%, respectively. There was a significant negative correlation between survival rate and degree of malignancy.
2.Tumor size (T) and regional lymph node metastasis (N) showed no significant correlation with M/V index.
3.In terms of the relationship of M/V index to the degree of histological malignancy, there was a significant positive relation between M/V index and the degree of malignancy. With respect to tumor control, group M, with a high M/V index and a high histological malignancy grade, had a significantly higher recurrence rate than did group I, with a low M/V index and a low histological malignancy grade.
4.The mode of invasion showed no significant correlation with the M/V index.
5.Multivariate analysis with quantification method II, revealed that a combination of M/V index, histological malignancy grade, and N classification showed the highest predictive accuracy, and the M/V index was the most powerful factor among them for the prediction of outcome.
The results indicate that the M/V index is very important in the prediction of outcome in patients with oral and soft palate squamous cell carcinomas.
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