Patients receiving pharmacotherapy frequently perform physical therapy simultaneously, and the effects of both therapies correlate each other, not maintain independent functions. In this first part, basic pharmacokinetics and effects of physical therapy on pharmacokinetics were reviewed. Pharmacokinetics consists of 4 steps; absorption, distribution, metabolism, and excretion. Each step has variables such as the bioavailability which shows the process of absorption, the volume of distribution which indicates the distribution in whole body, and the clearance which shows disappearance of drugs through metabolism and excretion, and those variables are influenced by physical therapy. The effect of most drugs correlates well with the concentration in blood, and the concentration is highly dependent on pharmacokinetics. The effect of drugs is therefore influenced by physical therapy. In case adverse effects of drugs appear during physical therapy, the possible effects of physical therapy on pharmacokinetics should be considered.
View full abstract