official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 11 , Issue 2
Showing 1-13 articles out of 13 articles from the selected issue
  • Type: Cover
    1971 Volume 11 Issue 2 Pages Cover1-
    Published: June 30, 1971
    Released: February 01, 2019
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  • Type: Appendix
    1971 Volume 11 Issue 2 Pages App1-
    Published: June 30, 1971
    Released: February 01, 2019
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  • Type: Index
    1971 Volume 11 Issue 2 Pages Toc1-
    Published: June 30, 1971
    Released: February 01, 2019
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  • Karl-Heinz Degenhardt, Hideki YAMAMURA, Jurgen Franz, Jurgen Klelnebre ...
    Type: Article
    1971 Volume 11 Issue 2 Pages 41-50
    Published: June 30, 1971
    Released: February 01, 2019
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    In proceeding with the comparative investigations with 5-fluoro-2'-deoxycytidine (F-CdR) in inbred mice we used a strain of random bred golden hamsters maintained for years at our laboratory and tested the embryotoxic and teratogenic dose response relations at stage day IX of pregnancy. It could be stated that the status of differentiation at stage day IX of pregnancy may be externally comparable with day X in the mouse (C57BL/6 and C57BL/10) except for some features. In experimental series attention was focused mainly on the skeletal system, i.e. the skull, the vertebral column and the limbs. Primordia of the vertebral column reacted most, while those of the skull reacted least. Analogous to the earlier investigation with mice we defined types of multiple regional skeletal defects of the three main parts. Animals with defects in all three main parts of the skeleton were the most frequent, whereas the combination of defects of limbs and vertebral column had lower incidence. With in-creasing doses multiple regional defects were increased while single regional defects declined. The types of malformations were described.
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  • Kiichi TAKANO, Masaaki SUZUKI
    Type: Article
    1971 Volume 11 Issue 2 Pages 51-57
    Published: June 30, 1971
    Released: February 01, 2019
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    Cyclohexylamine was found as a metabolite of sodium cyclamate in humans and dogs, which had orally received the sweetener (Kojima and Ichibagase, 1966). Since then, toxicity of cyclohexylamine has been studied by many investigators and it was revealed to cause chromosome aberrations in mammalian cells in vivo as well as in vitro (Legator et al., 1969; Stoltz et al., 1970; Tonmura, 1969, 1970). The present experiment was carried out to examine embryotoxic effects cyclohexylamine in mice. Pregnancy of ICR mice was timed by counting the morning on which the vaginal plug was found as day 0. Cyclohexylamine was diluted with distilled water and given orally to the pregnant mice at 100, 50, and 20 mg/kg/day for six days either from day O to day 5 or from day 6 to day 11 of gestation. Fetuses were removed on day 18 of gestation, all implantation sites counted and the living fetuses weighed and examined for external malformation and then for skeletal abnormality following staining with alizarin red S. Cyclohexylamine at 100 mg/kg/day was mildly embryolethal when administered from day 6 to day 11 of gestation. This dosage, however, was also mildly lethal to the adult female mice when administered for 6~10 days. Body weight of the living fetuses was significantly decreased when 100 mg/kg/day of cyclohexylamine was given from day 6 to day 11 of gestation. Such a growthsuppressing effect of the agent was not so evident in other experimental groups. No teratogenic effect of the agent was revealed in any experimental group. As a result, it was concluded that the level of embryotoxicity of cyclohexylamine is about the same as that of its subacute toxicity in the adult female. Discrepancies in the results of teratological examinations of cyclamate (Tanaka, 1964; Nees and Derse, 1967; Fritz and Hess, 1968; Klotzsche, 1969; Lorke, 1969 a, b) were discussed and it is assumed that cyclamate also has no teratological effect on the offspring when administered to pregnant animals.
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  • Hiroshi OHTORI
    Type: Article
    1971 Volume 11 Issue 2 Pages 59-65
    Published: June 30, 1971
    Released: February 01, 2019
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    Nulliparous female mice of ICR-JCL strain, 4-75 weeks old, and supplied by Japan CLEA Co. , Ltd. , were mated with mature male mice of the same strain. Pregnant females were injected with 25 mg/kg/day of prednisolone, suspended in CMC, subcutaneously for four consecutive days beginning on day 11 of pregnancy, and put to death on day 18 of pregnancy. Percentage of fetal loss with females treated was higher than among control females in all age groups except those older than 52 weeks. Analysis of multiple regression for incidence of cleft palate revealed that there were two phases, namely, a first higher phase from 4 to 23 weeks of age, and a second lower phase from 24 to 75 weeks of age. In age groups older than 24 weeks, incidence of cleft palate decreased according to age. Average body weight of live fetuses was lower in groups treated of any age. There was no characteristic relationship between the incidence of cleft palate and lit ter size or maternal body weight in the group treated of any age.
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  • Ryusuke NISHIMURA, Kazuhiro OKUNO, Nobuoki MORI, Akio ICHIMARU, Takesh ...
    Type: Article
    1971 Volume 11 Issue 2 Pages 67-73
    Published: June 30, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    A parasitic body, i. e. the fist-sized trunk with the arms and legs was attached to the epigastric region of a male newborn at full-term birth. The parasite showed spontaneous urination and movement of the extremities, and was detached successfully. The autosite died of cyanosis and dyspnea 7 days after birth. The autosite weighed 2,800g. No external anomalies except for the parasitic body were present. Cardiac anomalies including ventricular septal defect, overriding of the aorta and patency of the foramen ovale were detected. Besides, acute bronchopneumonia and congestion of the liver, kidney and spleen occurred. An artery arising from the right subclavian artery entered into the parasite in the region of the xiphoid process after running down behind the sternum. The blood circulating through the parasite flowed back into the left atrium of the autosite. The parasite weighed 400g. The upper and lower extremities were almost well-developed on both sides. No anomalies of the hands and feet were found. The head, thorax, upper abdomen and vertebral column were defective. In the abdominal cavity there were blind-end isolated small and large intestines with the appendix. No rectum and anus were formed. The uro-genital organs consisting of one fused kidney with the adrenal glands, urinary bladder, two ureters, prostate, penis and two testicles in the scrotum were also found. No anomalous genitals were seen. On x-ray examination, the autosite revealed almost complete formation of the skeleton. In the parasite the bones of the upper and lower extremities and pelvis were clearly shown, but the cranium, vertebrae, sternum and ribs were not indicated. It was pointed out that in the autosite cardiac anomalies were found, and that in the parasite the uro-genital organs as well as the lower portion of the skeleton were relatively well-developed.
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  • Kiichi TAKANO
    Type: Article
    1971 Volume 11 Issue 2 Pages 75-77
    Published: June 30, 1971
    Released: February 01, 2019
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  • Type: Appendix
    1971 Volume 11 Issue 2 Pages 79-87
    Published: June 30, 1971
    Released: February 01, 2019
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  • Type: Appendix
    1971 Volume 11 Issue 2 Pages 88-90
    Published: June 30, 1971
    Released: February 01, 2019
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  • Type: Appendix
    1971 Volume 11 Issue 2 Pages 91-
    Published: June 30, 1971
    Released: February 01, 2019
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  • Type: Cover
    1971 Volume 11 Issue 2 Pages Cover2-
    Published: June 30, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (26K)
  • Type: Cover
    1971 Volume 11 Issue 2 Pages Cover3-
    Published: June 30, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (26K)
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