official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 14 , Issue 1
Showing 1-12 articles out of 12 articles from the selected issue
  • Type: Cover
    1974 Volume 14 Issue 1 Pages Cover1-
    Published: March 31, 1974
    Released: February 01, 2019
    JOURNAL FREE ACCESS
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  • Type: Appendix
    1974 Volume 14 Issue 1 Pages App1-
    Published: March 31, 1974
    Released: February 01, 2019
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  • Type: Index
    1974 Volume 14 Issue 1 Pages Toc1-
    Published: March 31, 1974
    Released: February 01, 2019
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  • Hiroshi ITOU, Seiichi KAMBE, Yoshihiko MAEBA, Takashi HIRAI
    Type: Article
    1974 Volume 14 Issue 1 Pages 1-11
    Published: March 31, 1974
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Duplicitas lateralis is a rare form of conjoined twins. Only a few cases have been previously reported. The case presented involves duplicitas lateralis superior with many complicated anomalies. especially in the heart and the brain.
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  • Hitoshi YAMAWAKI, Harukazu NAKAMURA, Hajime FUJISAWA, Mineo YASUDA
    Type: Article
    1974 Volume 14 Issue 1 Pages 13-22
    Published: March 31, 1974
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    1. ICR-JCL mice were treated with an intraperitoneal injection of 600,000 IU/kg of vitamin A on day 10 of pregnancy, and divided into two groups. 2. In the first group, fetuses were removed and examined for external malformations on day 18 of pregnancy. All of the fetuses of vitamin A-treated mice showed micromelia, oligodactylia or syndactylia. 3. In the second group, the limb buds of the embryos were dissected out at 2, 4, 12, 24, 48 and 72 hours after the injection of vitamin A and were submitted to histological observations. 3-a. The first sign of the effect of hypervitaminosis A on the limb buds was found at 24 hours after the administration of vitamin A as an increase in the number of necrotic mesenchymal cells in the pre- and postaxial areas of the limb buds. 3-b. At 48 hours after the administration of vitamin A, the mesenchymal necrosis reached its maximum in the vitamine A-treated limb buds. 3-c. At 72 hours after the administration of vitamin A, digital rays and mesenchymal condensations were not recognized in the region corresponding to the first and second digits in the treated limb buds. 4. From these findings, it was concluded that the limb anomalies observed on day 18 of pregnancy were mainly due to the massive mesenchymal necrosis which was caused by hypervitaminosis A in the earlier phase of limb development.
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  • Koichi NISHIMURA
    Type: Article
    1974 Volume 14 Issue 1 Pages 23-40
    Published: March 31, 1974
    Released: February 01, 2019
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    Recently, in addition to gross and skeletal anomalies, visceral types have been examined in teratological studies using chemicals with fetal mice and rats, and Wilson's method has widely been used. However, the technique presents a disadvantage in that it is difficult to detect certain cardiac anomalies because of the cross sectioning of the thoracic area. Barrow and Taylor have suggested a rapid microdissection method for complete cardiac examination characterized by sagittal sectioning of the heart. Sagittal sectioning is more suitable for cardiac evaluation, but it is still not an efficient means to detect defects of the interventricular septum and atrioventricular valves or malposition of the major arteries. The present technique is a modification of Barrow and Taylor's. It embraces an inspection of the back side of all the thoracic viscera with the exception of the lungs after removing the organs from the pleural cavity, and utilizes a transverse section a little below the base of the heart. This technique and the following thoracic visceral malformations, produced mainly by chlorambucil in rat fetuses, are presented: dysplasia of the thymus and lung, diaphragmatic hernia, dextrorotation or levorotation of the heart, retroesophageal right subclavian artery, interruption of the aortic arch, coarctation of the aorta, transposition of the arterial trunks, persistent truncus arteriosus, vascular ring, right aortic arch, supernumerary coronay orifice, bicuspid aortic or pulmonic valve, VSD, common atrioventricular orifice, bifid anterior cusp of the mitral valve, mitral or tricuspid stenosis, double inferior venae cavae, and hypoplastic azygos vein.
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  • Hideo NISHIMURA
    Type: Article
    1974 Volume 14 Issue 1 Pages 41-45
    Published: March 31, 1974
    Released: February 01, 2019
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    This paper comments on a recently reported case of the mother of a 4-month-old microcephalic child who issued a claim against the National Railways on the ground that her boy's malformation was caused by CO intoxication during an accidental train fire about one year ago in the Hokuriku Tunnel during her third month of pregnancy. The author picked up the following five issues which are considered to be important for estimation of cause-effect relationship regarding the malformation and introduced the present state of knowledge for each of the issues. 1. Pathology, complication, genetic background of the child as well as the maternal history should be elucidated with all possible details. The obtained findings will allow the exclusion of a certain entity of microcephaly. 2. All known causal factors of microcephaly including the related animal studies should be referred to. 3. All case reports on CO poisoning during pregnancy with special reference to type of anomalies shown in the offspring should be studied. The results of animal studies on experimentally induced CO poisoning during pregnancy should also be considered. 4. Critical period with respect to induced microcephaly should be compared with the mother's stage of pregnancy when the accident accurred. Use of human and animal studies on radiation-induced microcephaly will be helpful in this respect. 5. Possible teratogenic effects of other concurrent environmental influences such as emotional shock and medical treatment undergone by the respective pregnant mother, should be considered.
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  • Type: Bibliography
    1974 Volume 14 Issue 1 Pages 47-70
    Published: March 31, 1974
    Released: February 01, 2019
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  • Type: Appendix
    1974 Volume 14 Issue 1 Pages 71-74
    Published: March 31, 1974
    Released: February 01, 2019
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  • Type: Appendix
    1974 Volume 14 Issue 1 Pages 75-
    Published: March 31, 1974
    Released: February 01, 2019
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  • Type: Cover
    1974 Volume 14 Issue 1 Pages Cover2-
    Published: March 31, 1974
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (22K)
  • Type: Cover
    1974 Volume 14 Issue 1 Pages Cover3-
    Published: March 31, 1974
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (22K)
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