official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 7 , Issue 2
Showing 1-14 articles out of 14 articles from the selected issue
  • Type: Cover
    1967 Volume 7 Issue 2 Pages Cover1-
    Published: June 30, 1967
    Released: February 01, 2019
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  • Type: Appendix
    1967 Volume 7 Issue 2 Pages App1-
    Published: June 30, 1967
    Released: February 01, 2019
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  • Type: Index
    1967 Volume 7 Issue 2 Pages Toc1-
    Published: June 30, 1967
    Released: February 01, 2019
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  • Joseph A. DIPAOLO
    Type: Article
    1967 Volume 7 Issue 2 Pages 61-63
    Published: June 30, 1967
    Released: February 01, 2019
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    Many parallelisms exist between teratogenesis and carcinogenesis. Somatic cell division is a prerequisite for both. Of the small number of compounds which have been bioassayed for both effects, the majority have produced malformations and cancer. The same compound may have different effects, dependent upon the stage of development of the organism at the time of exposure. Thus, a compound found to be carcinogenic to mature cells might be teratogenic to immature, embryonic cells. Some chemical agents given during fetal life produce cancer which becomes obvious during postnatal life. Oncology appears to have evolved further than teratology in that a number of clearly stated hypotheses have been proposed concerning the concepts of somatic mutation, alteration of immune response, protein deletion, and altered regulatory circuits. A review of pertinent literature in both disciplines indicates that these hypotheses of carcinogenesis may be applicable to studies in teratogenesis. Evidence on the mechanism of a carcinogenic agent might be used to elucidate its possible teratogenic activity. Conversely, detailed studies in organogenesis which are required for teratology can serve as a framework for carcinogenic investigation.
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  • James D. EBERT
    Type: Article
    1967 Volume 7 Issue 2 Pages 64-65
    Published: June 30, 1967
    Released: February 01, 2019
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  • Mineo YASUDA, Fumio ARIYUKI, Hideo NISHIMURA
    Type: Article
    1967 Volume 7 Issue 2 Pages 66-73
    Published: June 30, 1967
    Released: February 01, 2019
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    Pregnant ICR-JCL mice were given 50mg/kg of amphetamine sulphate orally once daily throughout pregnancy. In addition, 3mg/kg of triethylene thiophosphoramide (thio-TEPA) was injected intraperitoneally on day 10 of gestation. Some mice were treated only with amphetamine or with thio-TEPA. A group of an untreated control was also made. Animals were weighed every day, and the daily food and water intake was measured. Gestation was terminated on day 18 and the conceptuses were examined for intrauterine death and external and internal malformations as well as skeletal abnormalities. The summarized results are as follows: 1. Amphetamine caused a marked reduction in the maternal daily food and water intake only for the first two days. 2. Treatment with amphetamine and/or thio-TEPA did not reduce the litter size. 3. A slightly high fetal mortality was noted in the group treated with amphetamine. but not in the group treated with amphetamine and thio-TEPA. 4. Though the average body weight of fetuses was reduced by the treatament with thio-TEPA and/or amphetamine, no significant interaction between the two agents was observed . 5. The teratogenicity of thio-TEPA at the threshold level was not potentiated by the treatment with amphetamine.
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  • Kinichi HORII
    Type: Article
    1967 Volume 7 Issue 2 Pages 74-80
    Published: June 30, 1967
    Released: February 01, 2019
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    Unpedigreed white virgin mice were mated with mature male mice from the same colony. Five groups of copulated female mice were treated with a single intravenous injection of 80 mg per kg body weight alloxan on the 4th, 5th, 6th, 7th and 8th days of gestation respectively (the 4th-, 5th-, 6th-, 7th- and 8th-day groups). All mice were weighed on the 1st and 19th days of gestation, and blood sugar levels were tested 48 hours following the alloxan injection and on the 19th day of pregnancy. Pregnant mice were sacrificed on the 19th day of gestation, and fetuses were removed immediately by laparotomy and examined for externally visible defects. The fetal skeleton was examined for deformities after being stained with a dilute aqueous alizarin red-S solution. The frequency of mothers with one or more malformed fetuses was about 30 percent of successful pregnancies, and that of malformed fetuses was about 5 percent of live-borns in each group. The occurrence of fetuses having defects of the central nervous system decreased progressively with later treatments of alloxan during the period from the 4th to 8th days of gestation, and it was presumed that the defects might no longer appear with the alloxan injection after the 10th day of gestation. Hereupon, any noticeable relationship was not particularly seen between the frequency of over-all deformities and the date of alloxan treatment. No appreciable difference in blood sugar levels was observed between mice with and without malformed fetuses. On the other hand, however, fetal defects were found more frequently in mothers with a subnormal increase of the body weight as compared with mothers showing a sufficient increase during the period of pregnancy.
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  • Kunikazu KIDO, Keizo KAMIYA, Akira SUZUKI, Susumu HAYASHI
    Type: Article
    1967 Volume 7 Issue 2 Pages 81-86
    Published: June 30, 1967
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    A case of newborn malformation with microcephalus, crania bifida through which a mass of substantia cerebrovasculosa protruded, huge bilateral polycystic kidneys and uterus separata duplex et septum vaginae was reported. The mother of the newborn, whose mate was her cousin, is 1 gravida, and 1 para with an anencephalus. In the 2nd stage of labor, the head of the infant was delivered smoothly, but the trunk could not pass through the birth canal due to the huge polycystic kidneys, and the infant died with the enlarged abdomen and legs remaining in the uterine cavity. In order to diminish the body size of the infant, the polycystic kidneys were removed through the birth canal. The necropsy-findings of the newborn are as follows : Age ; 38 weeks of gestation (premature female). Bodyweight ; 2480g. Stature ; 43cm. The head is very small, the abdomen is enormously enlarged, and the brain is 80g, a quarter of the normal one. A part of the occipital bone has a defect of 1.5cm in diameter, and a soft red purple mass of 3cm in length is protruding from there, the base of which is connected to the brain itself. The kidneys, the right one weighing 220g, the left 440g, have the appearances of multiple cysts and seem to have caused the enormous enlargement of the abdomen described above. The microscopic examination revealed that the kidneys were composed of elongated cysts lined with a single layer of low cuboidal cells, mass of immature cells, which were probably of mesenchymal origin, and increased connective tissues, The weight of other organs are as follows : the heart 24g, the right lung 8.6g, the left 6.0g the liver 130g, the spleen 13.5g, the pancreas 3.0g, the thyroid gland 1.0g, the thymus 3.1g, and the right adrenal gland 1.5g, (the left had been lost during the removal of the huge kidneys). In the sex organs is found the complete duplication of the uterus, cervix, and vagina. The right and the left organs are located symmetrically, and almost of the same size.
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  • Hideo NISHIMURA
    Type: Article
    1967 Volume 7 Issue 2 Pages 87-89
    Published: June 30, 1967
    Released: February 01, 2019
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  • Type: Bibliography
    1967 Volume 7 Issue 2 Pages 91-109
    Published: June 30, 1967
    Released: February 01, 2019
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  • Type: Appendix
    1967 Volume 7 Issue 2 Pages 110-
    Published: June 30, 1967
    Released: February 01, 2019
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  • Type: Appendix
    1967 Volume 7 Issue 2 Pages 111-
    Published: June 30, 1967
    Released: February 01, 2019
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  • Type: Cover
    1967 Volume 7 Issue 2 Pages Cover2-
    Published: June 30, 1967
    Released: February 01, 2019
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    Download PDF (58K)
  • Type: Cover
    1967 Volume 7 Issue 2 Pages Cover3-
    Published: June 30, 1967
    Released: February 01, 2019
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    Download PDF (58K)
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