Background: 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) is assumed to be the most useful method for evaluating the viability of the myocardium. However, there are few reports regarding serial changes in
18F-FDG-PET images of acute myocardial infarction (AMI). We evaluated serial changes in glucose-loaded
18F-FDG-PET,
123I-β-methyl-p-iodophenyl-penta-decanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and
99mTc-Tetrofosmin (TF) gated SPECT images in patients with AMI.
Methods and Results: We enrolled 7 consecutive patients with first anterior AMI who successfully underwent percutaneous coronary intervention (PCI).
18F-FDG-PET images were obtained in the acute, subacute, chronic, mid-term and long-term phases.
123I-BMIPP and
99mTc-TF SPECT images were obtained in the subacute, chronic, mid-term and long-term phases. We determined the total defect score (TDS) for each image. The TDS of the glucose-loaded
18F-FDG-PET,
123I-BMIPP and
99mTc-TF SPECT images indicated significant serial decrease (P<0.001). Comparing these images, the TDS of the glucose-loaded
18F-FDG-PET images was larger than that of the
123I-BMIPP and
99mTc-TF SPECT images, and the TDS indicated
18F-FDG-PET>
123I-BMIPP>
99mTc-TF in all phases.
Conclusions: The defect areas of glucose-loaded
18F-FDG-PET images were significantly larger than those of
123I-BMIPP and
99mTc-TF SPECT images during 9 months follow-up of patients with successful PCI for anterior AMI. Additionally, the impairment of glucose metabolism was prolonged. (Circ J 2013; 77: 137–145)
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