Thirteen and a half years of activities of the International Society of Life Information Science (ISLIS) and the promotion of "Human Potential Science" are reviewed. ISLIS has sought and continues to seek the realization of the paradigm shift from material-oriented science and technology to a new paradigm including the consciousness, spirit and mind through research based on empirical and positive scientific methodologies, and consequently, to promote the development of health, social welfare, and education as well as social and personal peace of mind, and to contribute to the making of a peaceful world, at one with nature. Since the foundation of ISLIS in 1995, 27 symposia have been held and 27 issues of the Journal of ISLIS have been published periodically. ISLIS held the "Human Potential Science International Forum" in Chiba, Japan in 2002 and the "International Conference on Mind Body Science" in Seoul, Korea in 2004. It published the book Human Potential Science in 2004. The ISLIS has a worldwide presence with 9 international Information Centers and about 260 members in 10 countries.

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Sciences and pseudoscience are characterized by two functions: self-expression and indicative expression, in a manner similar to languages (as expressed by Taka'aki Yoshimoto, a Japanese leading poet and philosopher). Also, from the viewpoints of scientific methodologies and examples from the global warming issue, it has been discussed how pseudosciences can be avoided.

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The influence of music stimulation on heartbeat fluctuation was determined. Subjects were 10 healthy males aged from 22 to 23. The music used was a Japanese pop song entitled "Kujira-12" sung by the group Judy and Mary. The heartbeat was measured for 5min without any stimulation, then for 5min while being stimulated by hearing the song, and finally, for 5min with no simulation. The heart rate was unchanged, but LF/HF decreased significantly during stimulation (LF and HF denote the low frequency component and the high frequency component of the power spectra of heartbeat fluctuations, respectively). This suggested that the stimulation suppressed the activity of the sympathetic nervous system during stimulation. LF was increased significantly after stimulation. This suggested that the mental stress decreased after stimulation. The stimulation by the music used in the experiment seemed to be helpful for music therapy.

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The human body shows peculiar reactions corresponding to external stimuli for body maintenance. As one of the reactions, a change appears as a pulse wave produced autonomically. In this research, the reactions to stimuli received through the senses of sight, hearing, and smell were examined. A sound stimulus (music), a light stimulus (periodic blinking light), and a smell stimulus (perfume) were given, and the pulse waves were measured with an acceleration pulse wave measuring instrument. The changes of periodicity and the pulse wave fractal were obtained before, during, and after stimulation. Because there are many differences between individuals, the same value was not obtained for each subject. However, it was confirmed that peculiar changes appeared and an examination was added to pay attention to the change under stimulation.

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In this paper, the authors propose a new modeling method of an equivalent circuit of an acupuncture point with a negative impedance converter (NIC). This method has the advantage that one place can be measured in a few minutes. The value of C is measured from the resonance frequency by canceling the internal resistance of an acupuncture point using the NIC, and making the equivalent circuit equal to only the C circuit. Moreover, R can be known from the value of the load resistance of the NIC. In this method, the frequency response and the phase characteristic do not need to be measured.

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Chromogranin A (CgA) levels and pupil stress values (obtained by measuring eye pupil reactions to a flash of light) were employed as psychosomatic stress indices to determine stress reduction resulting from an activity, in this case stamping on even or uneven floor mats. Changes in salivary CgA concentrations and pupil stress values in volunteers when exposed to psychosomatic stress, when stamping on the mats, and when resting, were monitored. Increased CgA levels and pupil stress values were observed during solving of the Uchida-Kraepelin Performance Test. Subsequently, both stress indices were lowered during stamping. Finally, both indices decreased further during resting for 30min after stamping on the uneven mat, but no further decrease was detected after stamping on the even mat. The CgA level had a significant difference (P<0.05) 30min after stamping on the uneven mat compared to stamping on the even one. Good associations were evident between CgA levels and both pupil stress values and the subjects' assessments of stress sensation scores.

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When pieces of cucumber (Cucumis sativus "Shiroibo kyuuri") are exposed to the air, the intensity of photon emission from cucumber reaches the maximum about 5h later and then decreases gradually. The authors measured the time transition of intensity using 2 cameras; an image intensifier (I.I.) camera Model C2400-47, wave length 280-650nm and a CCD camera ImagEM C9100-13, wave length 400-1000nm. Samples of cucumber were treated for 30min by 70GHz millimeter wave (Extremely High Frequency: EHF) or non-contact healing. In the range from red to infrared rays, the intensity of photon emission was very large and there was a difference in intensities between directions of growth of samples. No effects of the millimeter wave were observed by either the I.I. or the CCD cameras; however effects of non-contact healing were detected by the I.I. camera. It was considered that red to infrared rays should be eliminated to detect effects of non-contact healing.

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After 30-min treatment by non-contact healing on experimental sample pieces of cucumber (cucumis sativus "Shiro-ibo kyuuri"), the intensities of biophotons from experimental and control samples were measured for 18h. In Cucumber series No.7 from June to December 2008, 24 volunteer healers (10 beginners and 14 veterans) were tested twice. As a result, the average of J values,an index of controlled healing power, was 0.084 (95% confidential interval was 0.026, n=24). There was no significant difference between beginner (J=0.081) and veteran healers (J=0.086). Only their ages showed a negative correlation with J values (r=-0.487, p=0.016, two tails). Analyses on the details showed a weak positive correlation between the bright factor of character traits and the difference of J values of 2 trials (r=0.466, p=0.022, two tails). It was considered that bright healers could adjust their healing ways to experiments. And there was a weak positive correlation between difference of the degree of the healing way "Loving intention (including prayer to gods, Buddha and spirits)" and the difference of J values of 2 trials (r=0.417, p=0.043, two tails). The correlation was obvious in veterans and it meant that they were more familiar with the ways of healing.

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