The International Society of Life Information Science (ISLIS) is to celebrate the 10th Anniversary of Founding in autumn 2005. ISLIS seeks to realize the paradigm shift from material-oriented science and technology to a new paradigm including the consciousness, spirit and mind through research based on empirical and positive scientific methodologies, and consequently, to promote the development of health, social welfare, and education as well as social and personal peace of mind, and to contribute to the making of a peaceful world, at one with nature. Since the foundation of ISLIS in 1995, 20 symposia have been held and 20 issues of the Journal of ISLIS have been published periodically. ISLIS held the "Human Potential Science International Forum" in Chiba, Japan in 2002 and the "International Conference on Mind Body Science" in Seoul, Korea in 2004. It published the book "Human Potential Science" in 2004. There are ISLIS Information Centers in 8 countries and there are about 230 ISLIS members in 10 countries. The ISLIS Office moved to the International Research Institute (IRI), Chiba, Japan in April 2005. ISLIS has started the 10th Anniversary Campaign to increase its membership; this is critical for the Society to have an important role in Human Potential Science in the 21st century. The budget status of complementary and alternative medicine (CAM) is reported.

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We considered whether the qigong acquisition degree could be evaluated by measuring the change of pulse delay time which tends to decrease during the practice of qigong. The standing posture qigong which is without movement was used. The subject was someone whom we had measured and analyzed data from for more than four times at about half year intervals. In this way we could correct for personal unevenness. We found that to some extent the acquisition degree could be evaluated by values obtained from pulse delay time and R-R interval.

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This study measured physiological characteristics at the time of breathing for a Qigong master while doing the Standing Posture exercise. Similarity of the respiratory cycle at the time of the exercise and the physiological characteristics cycle was observed. It seemed that the autonomic nervous system activity by breathing and by doing the exercise mainly depended on a change of parasympathetic nervous system activity.

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Immunoregulatory processes are influenced by the brain and the brain shows some lateralized immunomodulation. Physiologically direct photic routes to the frontal lobes are implicated also in human and this penetration of visible light through the cranial bone is considered to influence immune response. To detect immunomodulation by the brain and its lateralization non-invasively and effectively, we examined natural killer cell activity (NK activity) and number of peripheral NK cells (CD57^-CD16^+) in an experiment in which we exposed each subject's forehead to a red light diode while their eyes were shielded. We also studied the relationship between changes in these immunological parameters and the change in brain alpha waves. No significant changes in effective amplitude of alpha waves, NK activity and in the level of CD57^-CD16^+ measured immediately before and after the 21st period were observed. But among these parameters, a correlation was observed between the change in level of CD57^-CD16^+ and the change in effective amplitude of the first 5-minute alpha waves. This correlation was significant in the right cerebral hemisphere. The right cerebral hemisphere is considered to be related to the release of some neurotransmitter which increases circulating NK cells.

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The essence of the meridian system and the meridian points still remain unclarified even after many years of research and discussions. In North Korea, Dr. Kim Bonghan claimed that he had found the essence of the meridian system (the Bonghan ducts) and the meridian points (the Bonghan corpuscles) and he wrote several papers, beginning in 1961. His theory is called the "Bonghan Theory". In Japan, Dr. Satoru Fujiwara and others claimed that they had succeeded in supplementary examinations of the Bonghan Theory in the 1960's. However, mainstream scientists of the related academic societies have disagreed with the Bonghan Theory. In the early 2000's, Professor Kwang-sup Soh and others at Seoul University, and a few other groups in South Korea claimed that they had got supporting data for the theory through many supplementary examinations and they wrote many papers. The 10 presentations were made at the "International Congress on Mind Body Science" in joint session with the 18th Symposium on Life Information Science, at Yonsei University, Seoul, 26-29th August 2004. The 10 proceedings were published in the Journal of International Society of Life Information Science, Vol.22, No.2, 2004. The first Mini Symposium on this topic was held in March 2005 at the 19th Symposium and 7 related proceedings were published in Vol.23, No.1, 2005. On the other hand, the mainstream scientists of the related academic societies in Japan continue to search in other directions. It is very important to discuss the essence of the meridian system scientifically. I hope that many professionals and other interested persons will join this Mini Symposium.

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After long negligence of the studies done by Bonghan Kim and Satoru Fujiwara, an intensive investigation into the intravascular threadlike structures called Bonghan ducts was begun in the Biomedical Physics Laboratory of Seoul National University. It led to a method to identify the threadlike structures as Bonghan ducts using acridine orange fluorescence staining. The size, shape, and distribution of nuclei clearly exhibited the features of Bonghan ducts. The Bonghan ducts and corpuscles on the organ-surfaces of rabbits and rats were observed by three independent teams, and their morphological characteristics were studied. Histological aspects obtained by H&E and Feulgen reactions were in agreement with Kim's and Fujiwara's results. Bonghan ducts inside large lymphatic vessels were observed by using the Janus Green B staining method, which completely resolved the long standing question on the possible confusion between Bonghan ducts and lymphatic vessels. The granules (known as San Al), obtained from the organ-surface Bonghan corpuscles, were shown to contain DNA. The nature of San Al motion was also analyzed to reveal non-thermal features and was shown to be affected by UV-A light.

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Adult stem cells have been intensively studied for their cell-therapeutic potential to renew and replace lost cells in any damaged tissue or organ. Yet, the origin of adult stem cells remains an important question to be resolved. On the other hand, microcells have been used for cell fusion in cancer research. A microcell contains a micronucleus that has one or a few chromosomes with a small amount of cytoplasm. Recently it was reported that microcells can transform into undifferentiated cells, which suggests microcells are a possible origin of adult stem cells. In the early 1960's Bonghan Kim claimed that anatomical structures corresponding to acupuncture meridians had been observed and that they formed a circulatory network distributed throughout a body which was entirely different from the blood, lymph, or neural systems. A liquid whose most important component was microcell-like bodies called "Bonghan granules" flowed in this new circulatory system. Granule sizes, shapes, structures and DNA-content were similar to those of microcells. Furthermore, Kim observed that the Bonghan granules grew and regenerated or repaired damaged cells. Recently, after decades of neglect, Kim's studies are being considered again, and some of his findings, including Bonghan granules, have been reconfirmed. We put forward a hypothesis on a possible origin of adult stem cells : The Bonghan granules that flow in the Bonghan circulatory network are naturally generated microcells and they are capable of growing and differentiating into tissue cells and also regenerating the tissues of injured organs. Any differentiated tissue cells in mammalian organisms may have a capacity for self-reproduction and self-renewal by specific "microcell-like Bonghan granules". Understanding of the origin of adult stem cells in animals is one of the most fundamental tasks in modern biomedicine and may result in new approaches to the treatment of many diseases in the future.

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Recently, threadlike structures on the surfaces of internal organs were rediscovered which are called Bonghan ducts and corpuscles as named by Bonghan Kim, their discoverer about 40 years ago. Many morphological characteristics of the ducts and corpuscles have been found but there are no studies about their function. In this paper, the chemical analysis of Bonghan liquid which flows inside the Bonghan ducts and corpuscles was done to start their functional study. We concentrated on examining the existence of adrenaline since Bonghan Kim asserted that Bonghan ducts and corpuscles were deeply related to the function of hormones such as adrenaline. A liquid-phase microextraction method in capillary electrophoresis was used to overcome several difficulties : minute sample volume, highly complex components, and very low concentration. Fluorescein isothiocyanate derivative of adrenaline in the Bonghan liquid were detected about 10.8 minute with laser-induced fluorescence. Our result suggested that the Bonghan system is related to the secretion and the flow of hormones.

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The effects of UV-A and visible light on the motion of Bonghan Granules (BHGs) were reported. It was shown that the average velocity and acceleration increased significantly after irradiation with UV-A light (355-375nm), although there was no notable change after irradiation with blue light (380-420nm). The absorber of the UV-A light might be DNA molecules inside the BHGs and the BHG could be thought as an active Brownian particle.

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Crystalline and auto-fluorescent structures could arise in acupuncture meridians and fish ducts which react to light, magnetic fields and other treatments. The symbiotic fish light organ which has the specific function of producing light is compared with the thread-like structures found in both mammalian connective tissue and human skin. A motility biosensor based of Fourie spectra and the realtime parameters detection was developed using the light intensity fluctuation spectrometry. Dia-paramagnetic changes of auto-fluorescent ducts were induced under blue light illumination.

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In a previous study using near-infrared spectroscopy (Yoichi et al, 2002), the authors found spontaneous blood flow change often occurred at both temporal lobes while guessing for hidden figures (clairvoyant condition). This phenomenon was considered to have a relationship to the degree of impression formulation of figures. In the present study, the authors looked at details of the phenomenon. There were 14 participant volunteers. One trial consisted of a 3-minute guessing period and a 3-minute rest period, and 1 run consisted of 3 trials and 69 trials were done in total. The target figure was selected from 5 figures by a pseudo random number function. Then it was displayed on a CRT covered by a gray paper box. After the 3-minute guessing period, subjects gave their answers and degrees of impression formulation (3 degree method). The spontaneous blood flow change at the temporal lobe was observed in 10 trials. The degree of impression formulation was high when the change occurred (p<0.001, one-tail). The change also often occurred when subjects made their responses after guessing although the change did not relate to the degree of impression formulation. Ten guessing results were correct, but this number was not significant. Moreover, 3 of 10 correct trials were obtained when the spontaneous blood flow change occurred although it was not significant (p=0.06, one-tail). The relationship between the correct response and the spontaneous blood flow change should be researched in further studies.

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There is a long history of using hypnosis in treatment, and it is well known that various mysterious phenomena are generated. However, changes in physiology of the person in hypnosis are not well understood. In this study, we had the cooperation of Master Mudou IDE. He hypnotized a female subject T and we measured the physiology of the subject. The objective was to clarify what kind of influence hypnosis has on the Physiology. The result was that when the subject was hypnotized, we were able to show that abdominal respirations changed from normal condition, though these changes were not visible. In addition, we understood that there were two situations in which the blood flow either increased or decreased. Also, we understood it was related to the heart rate. We showed that these phenomena acted on the autonomous nervous system. In addition, we were able to show that brain activity decreased greatly when subject was hypnotized from the EEG measurements. When the subject was hypnotized, the hypnotist said to the subject as follows, "you breathe in cigarette smoke." Then the subject reacted. We understood that the subject reacted in the beta 1 region of the brain, and that the activity of the brain waves was greatly suppressed. In other words, it was understood that hypnosis not only could decrease brain activity and could also stimulate it.

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Scientists belonging to many different fields are researching the inner workings of the human body and mind. Human consciousness power as a kind of hidden ability has been researched for more than twenty years in China, including the topics of how consciousness influences matter, how one human's consciousness affects other humans, and how consciousness universally influences the whole-person-life-system. [P1] Modern science has developed technologies with no spiritual influence. But in our researches, we have seen that consciousness power can change physical and physiological phenomena^<1, 2>. For research in the new science we need to think about our body, mind and spirituality as the whole-person-life-system[P2]. Here we will show the thought of our research system structure.

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Using the thermal image quantitative method, we investigated the effects of hospitalization on patients with diabetes after taking thermal images of patient dorsa. Seventeen patients (10 males and 7 females) were hospitalized for 3 days each in the study. Their average age was 62.6 years (SD 7.9). Subjects underwent integrative medical care such as Okada purifying therapy (OPT), eating a diet of foods that were made from vegetables grown by the MOA nature farming method, and art therapies. Their thermal images were measured in a constant temperature hospital room (26±1 deg) before and after the hospitalization using an infrared thermal imaging camera. At the same time, OPT therapists recorded stiff and feverish points on based their own palpation. Thermal images were analyzed by software to transform the measured thermal images into a standard shape image of the human dorsum. The average, standard deviation, difference, and t-test value of the images were calculated. As a result, although images in the shoulder, kidney and waist regions were not symmetrically distributed before the hospitalization, the thermal images in these regions were symmetrically distributed after it. In the neck, shoulders and waist, the changes of thermal images corresponded to the recorded stiff and feverish points. Although therapists recorded some feverish and some stiff points in the back pancreas region, pecks of the analyzed thermal distribution in same region did not appear. Therefore, we concluded the thermal distribution analysis of the dorsum is a useful method to assess changes of various thermal images.

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The softness of the shoulders ("stiff shoulder") is examined as a new measure of degree of health. Phantom experiments are carried out for 3 types of muscle hardness meters for investigating the influence of a soft surface layer. Five different silicone phantoms with different softness are used. Two group examinations are carried out. Their distribution and correlation between the softness of shoulders and body fat percent are analyzed. The possibility for a new measure of therapy effects is confirmed from the study.

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The purpose of the present work was to investigate a mechanism of synchronicity from the viewpoint of quantum theory and holographic cosmology. A model of consciousness has been proposed that all information, including human consciousness, of the 4-dimensional spacetime of the universe is recorded on a 3-dimensional boundary. This conscious field and a certain physical phenomenon generated simultaneously are called synchronicity in the present work. A model for synchronicity was proposed that two particular information quantities I_<Cons>(r, it)/I_B(r, it) expressed by the imaginary time on a 3-dimensional boundary resonate. These I_<Cons> and I_B quantities have the condition of implication and transcendence including information of the whole universe. The synchronicity phenomenon with the information quantity I_<CB> occurs in the 4-dimensional space-time r_CB and real time t_CB in the overlapped region of the phenomena and consciousness. Another model was also proposed that the synchronization/resonance [(px-Et)_C=n(px-Et)_<Univ>] region of the consciousness wave function Ψ_C=Ae^<i(px-Et)/h> and wave function of the universe Ψ_<Univ> appears in the usual 4-dimensional spacetime. Further discussion on the mechanism is expected.

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The purpose of the present work was to investigate the effects of visual imagery of a sunlight incident at meridian points on an electroencephalogram (EEG) and determine a mechanism of light imagery. Imagery visualization of the sunlight incident at the Yingtang meridian point and filling of the body with sunlight were accompanied by slowing of the EEG over the whole region. It was assumed that consciousness exists on a 3-dimensional boundary based on a weak holographic principle in this work. Then, photons in a 4-dimensional spacetime are equivalent to photons in the image within the brain on the 3-dimensional boundary hologram. Photons would appear as tunnel photons described by quantum brain dynamics in the actual brain, and they would affect brain neurons and EEG changes. Chaos theory analysis showed that the Lyapunov exponent and entropy of brain waves increased during the imagery, and that the imagery promoted the neurochaos phenomenon based on the neuron activity.

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As a fundamental study on detecting liquor fragrance, changes in electronic characteristics (impedance Z and resonant frequency f) of a quartz resonator on exposure to the fragrance were determined. The surface of the resonator was coated with a squalene or lecithin film which absorbs liquor fragrance molecules. There was a weak correlation between the impedance change rate &lrtri;Z/Z and the frequency change rate &lrtri;f/f of the resonator when it was exposed to air saturated in liquor fragrance molecules. The experiment result suggested that using the impedance and frequency changes of the quartz resonators could lead to realizing the liquor fragrance detector.

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Despite the increasing interest in examining spirituality in psychological and educational health-related studies, there is a paucity of instruments that measure this construct. The objectives for this study were (1) to develop a valid and reliable assessment tool of spirituality that would be useful in psychological and educational settings, and (2) to investigate a conceptual model of an individual's mature spirituality. A multi-site, cross-sectional survey was conducted using university students in a large metropolitan area (N=1396). The instrument reliability (Cronbach's α, test-retest) and conceptual validity by exploratory factor analysis, and concurrent validity with the SSTT (Scale of Self-Transcendental Trait) and the scale of SOC (Sense of Coherence) were determined. The exploratory factor analysis identified three factors : Will, Joy and Sensitivity of Spirituality. A measurement tool for Spirituality was developed based on the exploratory factor analysis, called the SBAS (Spiritual Behavior, Attitude, Sensitivity)-Test and it was found to have sufficient reliability, and to show high correlations with SOC, (r=0.47, P<0.001) among subscales; and between Will, Joy and SOC, (r=0.49, P<0.001 r=0.57, P<0.001), and Sense and SSTT (r=0.61, P<0.001). It was concluded the SBAS-Test is a valid and reliable assessment tool that can be used in psychological and educational settings. In addition, Will and Joy were identified as in the health related domain of Spirituality; however Sensitivity itself (transcendental aspect) is not on the health side of Spirituality.

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There is a widely recognized criticism that the scientific approach to consciousness or the soul tends to fall into the category error and become reductionism, for consciousness and the soul are each an invisible, immeasurable construct. In this article we introduce a case approaching the truth in consciousness studies through an interdisciplinary research group for spirituality; we use both the empirical scientific method and knowledge from direct experiences. This methodology makes it possible to bring to awareness the meta levels of consciousness, or the spiritual level. A holistic or integral approach does not mean to accept everything or simply to gather ideas from different fields. The attitude towards interdisciplinary study needs to include a willingness to experience the other's specialty as our own without denying our own status. The study group can serve as an example to embody spirituality.

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Children with severe cerebral paralysis were trained in coordinating their motions, in balancing themselves, or in making rapid motions by utilizing the reactions from a ball called "the facilitation ball" which can be deformed flexibly. Through this training, the paralyzed children developed their abilities of their own accords. They attained remarkable achievements in calligraphic writing with an ink brush[0] which gave them great confidence and hope.

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Kidoujutu is a treatment to relieve pains and aches, to resolve stresses and to connect with the balance between humans and natural forces which is called "Qi".

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The International Society of Life Information Science (ISLIS) is to celebrate the 10th Anniversary of Founding in autumn 2005. ISLIS seeks to realize the paradigm shift from material-oriented science and technology to a new paradigm including the consciousness, spirit and mind through research based on empirical and positive scientific methodologies, and consequently, to promote the development of health, social welfare, and education as well as social and personal peace of mind, and to contribute to the making of a peaceful world, at one with nature. Since the foundation of ISLIS in 1995, 20 symposia have been held and 20 issues of the Journal of ISLIS have been published periodically. ISLIS held the "Human Potential Science International Forum" in Chiba, Japan in 2002 and the "International Conference on Mind Body Science" in Seoul, Korea in 2004. It published the book "Human Potential Science" in 2004. There are ISLIS Information Centers in 8 countries and there are about 230 ISLIS members in 10 countries. The ISLIS Office moved to the International Research Institute (IRI), Chiba, Japan in April 2005. ISLIS has started the 10th Anniversary Campaign to increase its membership; this is critical for the Society to have an important role in Human Potential Science in the 21st century. The budget status of complementary and alternative medicine (CAM) is reported.

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