The Journal of Japanese College of Angiology
Online ISSN : 1880-8840
Print ISSN : 0387-1126
ISSN-L : 0387-1126
Volume 52 , Issue July
Showing 1-2 articles out of 2 articles from the selected issue
The 52st Annual Meeting; Recommended Paper
Original Article
  • Shukei Sugita, Takeo Matsumoto, Toshiro Ohashi, Kiichiro Kumagai, Hiro ...
    2012 Volume 52 Issue July Pages 277-283
    Published: July 10, 2012
    Released: July 10, 2012
    To predict the rupture of thoracic aortic aneurysms (TAAs), the relationship between stiffness and rupture pressure was investigated in a pressure-imposed test. Each quadrilateral (ca. 20×20 mm2) specimen of human TAAs or porcine thoracic aortas (PTAs) was pressurized until rupture or up to 4500 mmHg. Tension per unit length (T) and strain (ε) of the specimen were calculated from loaded pressure (P) and deformations of the specimen. Stiffness (S) was determined as the slope of the T-ε curve. Blood pressure in vivo (Pvivo) was estimated from P, T, and diameter of the specimen. Stiffness of PTA specimens increased with an increase in Pvivo, while that of TAA specimens reached a plateau in a low-Pvivo region. To evaluate this phenomenon quantitatively, a yielding parameter (τP), i.e., Pvivo at which the stiffness S reached a plateau level, was determined by fitting an equation S=CP{1–exp(–PvivoP)} to the S-Pvivo curve. The parameter τP correlated significantly with the rupture pressure in vivo. This parameter also correlated significantly with the area fraction of collagen, indicating that collagen composition caused changes in the τP in TAA. Since the yielding parameter can be obtained from clinical data, τP can be used for rupture risk estimation.
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Original Article