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Souta Takasaki, Tetsuaki Kubota
2002 Volume 2002 Issue Supplement109 Pages
1-10
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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The antitumor effect of human interferon (IFN-β ) and mouse interferon on the growth of human melanoma cells (SK-14) trnsplanted into nude mice was examined. Cell growth in nude mice was supressed by daily administration of IFN-β, depending on the dosage and administration route. The most prominent effect was obtrained by intratumoral injection of IFN-f3, and intraperitonial injection of IFN-β was unsuccessful.
A lesser theraputic effect was achieved by intratumoral injection of mouse interferon. This finding led us to speculate that the antimor effect of IFN-β might be explained by its anticellular activity rather than its immunomodulating effect.
Pharmacokinetic studies of IFN-β in the nude mouse have reported that relatively high interferon titers in the tumor mass and lymph node were detected for a long time after intratumoral injection.
On the other hand the plasma, lung and liver levels of interferon were negligible. Inhibition of nodal metastasis was also suggested.
Clinical observations of fourteen cases of cutaneous and mucosal primary melanoma of the head and neck encountered during the past twenty years were reviewed. Two patients who underwent radical excision of a wide area survived for over 10 years. However, the specific anatomical structure of the head and neck make such treatment difficult. Three patients who underwent palliative reducing operations with chemotherapy, radiotherapy and immunotherapy died within three years.
Seven cases were treated with interferon. In these cases, complete response was observed in five cases treated with local injection of interferon, and partial response was observed in one patient who underwent intraarterial administration of interferon. The role of interferon in the treatment of melanoma in the head and neck is worthy of special attention.
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Yoshiyuki Kadokura, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Ha ...
2002 Volume 2002 Issue Supplement109 Pages
11-16
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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After extended excision of the cervical trachea, the airway is usually reconstructed by end to end anastomosis of the trachea or transplantation of the skin and other autologous grafts. However, these surgical methods do not always produce succsessful results in respect of surgical invasion, complications and postoperative QOL.
Although reconstruction of the trachea using an artificial trachea is considered to be simple and easy, there is no suitable material for this purpose.
We tried to reconstruct the airway with an artificial trachea made from collagen.
As a result, the collagen graft was absorbed about 12 weeks after implantation and replaced by connective tissue with suitable rigidity. The inner wall of the reconstructed airway was lined by a ciliated columnar epithelium. We conclude that collagen products after cross-linkage with a suitable compound can be used for tracheal reconstruction.
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Satoshi Naitoh, Kazuo Matsui, Yoshiyuki Kadokura, Masaki Iida, Dai Nag ...
2002 Volume 2002 Issue Supplement109 Pages
17-20
Published: December 10, 2002
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Dermatophytosis of the external auditory meatus is a very rare disease. Within otomycosis,86% is in the
Aspergillus. We report five cases of dermatophytosis of the external auditory meatus. All the patients visited us because of severe itchiness in the external auditory meatus. Apart from Case 2, all the patients were affected with dermatophytosis in other parts of their body. An otoscopic examination revealed white cherumen in all of the cases and a KOH method revealed it to have numerous fungal elements. The fungal culture was identified as
Trichophyton rubrum. Itraconazole treatment was very effective and all of the cases recovered completely.
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Masaki Iida, Kazuo Matsui, Dai Nagase, Hajime Hanaoka, Yoshihiro Yamad ...
2002 Volume 2002 Issue Supplement109 Pages
21-28
Published: December 10, 2002
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Forty four cases of hearing loss due to head trauma at Showa University Fujigaoka Hospital from June 1994 to January 2001. These diseases were 29 traumatic tympanic membrance perforation, two ossicular dislocation, seven traumatic fractures of the temporal bone, five of those complicated, and one conductive hearing loss after head trauma. Thirty seven cases underwent surgery,17 myringoplasty,19 tympanoplasty and one meatoplasty. The success rate was 36/39 (97%). Cases thought to require a surgical procedure should undergo the operation because of its effectiveness.
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Masahiro Katsuno, Kazuo Matsui, Hideki Takemura, Dai Nagase, Tetsuaki ...
2002 Volume 2002 Issue Supplement109 Pages
29-35
Published: December 10, 2002
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Bilateral conductive deafness is common in mandibulofacial dystosis (Treacher Collins syndrome). This deafness is due to malformation of the ear ossicles. We report two cases of this syndrome with conductive deafness. The first case was a 35-year-old female who underwent a tympanoplasty III-c. We observed a malformation of her malleus, and the movement of her incus and stapes was not limited. After the operation, her hearing was improved significantly. The second case was an 11-year-old boy complicated with bilateral otitis media with effusion and probable malformation of the ear ossicles. After curing the OME, we are going to operate. We believe that surgery must be performed on patients with conductive deafness due to malformation of the ear ossicles, including Treacher Collins syndrome.
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Kazuo Matsui, Hideki Takemura, Yoshiyuki Kadokura, Yuichiro Yanagi, Te ...
2002 Volume 2002 Issue Supplement109 Pages
36-39
Published: December 10, 2002
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A 44-year-old female with van der Hoeve syndrome is reported. She showed symptoms of blue sclera and hearing loss, but had no tendency towards spontaneous fractures. Her father also had blue sclera and hearing loss. Her daughter and son had blue sclera and many spontaneous fractures, but had normal hearing.
Pure tone audiometry showed a mixed hearing loss of 73.3 dB in the left ear, and 53.3 dB in the right ear. The operation findings of both ears revealed the pathophysiology of deafness to be fixation of the stapedial footplate but the shapes of the stapes were normal. A small fenestra stapedotomy was perfomed in both ears. She obtained improvement in both hearing levels. The diagnosis and therapeutic problems of this syndrome are discussed with a review of the literature.
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Yuichiro Yanagi, Kazuo Matsui, Yoshiyuki Kadokura, Hideki Takemura, Da ...
2002 Volume 2002 Issue Supplement109 Pages
40-44
Published: December 10, 2002
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Chitin is extracted from crab shells. A chitin membrane was used for repairing perforation of the tympanic membrane in 98 patients over 6 years (102 ears). The overall success rate was 81.9% for tympanic membrane perforation. Successful repair of traumatic tympanic membrane perforation was achieved in 100% of patients, and 76% of chronic otitis media-related perforations were successfully repaired with the chitin membrane. We emphasize that this method is useful for ENT outpatients, because as soon as we pacthed a chitin membrane on to the ear drum perforation, hearing loss and ear fullness were recoverd, and the ear drum perforation closed in a short time.
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Yoshihiro Yamada, Kazuo Matsui, Hideki Takemura, Dai Nagase, Yuichiro ...
2002 Volume 2002 Issue Supplement109 Pages
45-49
Published: December 10, 2002
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We attempted to close 19 tympanic membrane perforations with fibrin glue under general anesthesia in our hospital from 1995 to 2000.
Seven patients were less than 10 years old. They were admitted for three days and must be carefully selected. We succeeded in closing the tympanic membrane perforations at a rate of 100 %. Twelve patients were over 10 years old and had tympanic membrane perforations on both sides. These were operated on at the same time. We succeeded in closing the tympanic membrane perforations at a rate of 75% on the myringoplasty side and 100% on the tympanoplasty side.
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Takayuki Ota, Kazuo Matsui, Hideki Takemura, Dai Nagase, Hajime Hanaok ...
2002 Volume 2002 Issue Supplement109 Pages
50-53
Published: December 10, 2002
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For effective tympanoplasty when bacterial infection is present, it is desirable to operate on a dry drum. We performed 25 tympanoplasties for chronic otitis media with infection of
Pseudomonas aeruginosa over 8 years in our hospital from May 1993 to April 2001. These ears consisted of 14 ears with cholesteatoma,8 ears with chronic otitis media perforation and 3 ears with postoperative chronic otitis media. We used sensitive antibiotics and washed the tympanic cavity preoperatively. Although they took sensitive antibiotics during postoperation,2 patients suffered swollen posterior external ears. And the gauze on the reconstructed drum was cultured in 15 cases. Most chronic otitis media patients with
Pseudomonas aeruginosa can make good progress, provided they take sensitive antibiotics. Often it was a mixed infection that caused complications. We should pay attention to infection by MRSA (Methicillin resistant
Staphylococcus aureus), drug resistant CNS (Coagulase-negative staphylococcic) and
Bacteroides. We should be careful to watch for symptoms of infection postoperatively in the gauze, on the posterior of the external ear and in the external canal.
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Masaki Iida, Tetsuaki Kubota, Kazuo Matsui, Souta Takasaki, Yoshiyuki ...
2002 Volume 2002 Issue Supplement109 Pages
54-57
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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Various histological types of tumors can originate in the nasal septum. We report 10 cases of malignant tumors of the nasal septum, treated over the past 18 years. The pathological diagnoses of the tumors were as follows; six cases of squamous cell carcinoma, two adeno carcinomas, one malignant lymphoma, and one malignant melanoma. Six cases of squamous cell carcinoma and two cases of adenocarcinoma were treated with a combination therapy of radiation, chemotherapy and/or surgery. One malignant lymphoma was treated with radiation and chemotherapy, and one malignant melanoma was treated with interferon. A histologic examination is considered mandatory for such cases since the optimum treatment depends on the histological findings.
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Makoto Ishida, Tetsuaki Kubota, Kazuo Matsui, Kazumasa Ohashi, Masaki ...
2002 Volume 2002 Issue Supplement109 Pages
58-62
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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A case of olfactory neuroblastoma is reported. A 74-year-old man visited our hospital exhibiting left nasal obstruction and bleeding in May 1997. An examination revealed a large tumor in his left nasal cavity; its surface was smooth and it bled easily. The patient did not have any visual acuity difficulties and the cervical lymph nodes were not swollen. A CT scan revealed a large tumor in his left nasal cavity and maxillary sinus which did not extend into the cranial space or eye socket. There were no bone defects. The patient underwent surgery for an olfactory neuroblastoma in June 1997. Based on the pathological findings, we made a diagnosis of olfactory neuroblastoma.
The patient was treated with radiation therapy after surgical therapy.45 Gy radiation therapy was added. The patient was followed up for 1 year and 6 months. In January 1999, there was local tumor reccurence and the tumor invaded his brain. Unfortunately, he died soon after from this local recurrence of his brain tumor in June 1999.
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Makoto Ishida, Tetsuaki Kubota, Kazuo Matsui, Souta Takasaki, Yoshiyuk ...
2002 Volume 2002 Issue Supplement109 Pages
63-68
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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A case of malignant fibrous histiocytoma is reported. A 25-year-old male was referred to our hospital with a tumor in the right maxillary sinus which was invading the surrounding tissue and causing bone destruction. After radiotherapy and selective chemotherapy, he received a total maxillectomy. However, two years and five months later, local lesions recurred. Although several chemotherapy strategies and additional surgical operations were performed, he died from local brain lesions after five years and four months of treatment.
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Hideki Takemura, Tetsuaki Kubota, Kazuo Matsui, Masaki Iida, Hajime Ha ...
2002 Volume 2002 Issue Supplement109 Pages
69-75
Published: December 10, 2002
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In cases of superior advanced maxillary carcinoma, the zygomaticoorbital floor is reconstructed using a rectus abdominis muscle flap or a osteocutaneous scapular flap after a radical maxillectomy including the zygomaticoorbital floor bone. In cases with residual disease in the zygomaticoorbital floor without an invading palatine process after radiotherapy and chemotherapy, we made an effort to keep the palatine process intact and reconstruct the zygomaticoorbital floor using a collagen plate. On the other hand, in cases with residual disease in both the zygomaticoorbital floor and palatine process, we performed a radical maxillectomy and carried out the reconstruction using an osteocutaneous scapular flap combined with a collagen plate. We performed a partial or radical maxillectomy for 8 patients with superior advanced maxillary carcinoma and reconstructed the zygomaticoorbital floor defects using a collagen plate. One was reconstructed by combining a collagen plate with an osteocutaneous scapular flap. By this method we succeeded in preventing eye ball sinking.
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Yoshiyuki Kadokura, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Yu ...
2002 Volume 2002 Issue Supplement109 Pages
76-80
Published: December 10, 2002
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After total maxillectomy patients sometimes develop diplopia and difficulty in swallowing. In this study we tried using an osteocutaneous flap with a lattisimus dorsi flap and a collagen plate to reconstruct the maxilla. We thought that using this method would be useful after a total maxillectomy.
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Tatsuya Nishimura, Tetsuaki Kubota, Kazuo Matsui, Takashi Ohtani, Ikuk ...
2002 Volume 2002 Issue Supplement109 Pages
81-85
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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A case of granular cell tumor of the larynx is reported. A 39-year-old man presented with a polypoid vocal cord and a laryngeal tumor causing hoarseness. He underwent excision of the tumor under a direct laryngoscopy. A light microscopic examination of the tumor revealed a granular cell tumor. A relapse occurred 18 months after the first operation and total excision of the tumor was performed under a direct laryngoscopy. No recurrence of the tumor was seen 20 months after the second surgery. The tumor was composed of granular cells with many PAS-positive granules of variable size and some myelin-like bodies in the cytoplasm, and are anti-S-100 protein positive. In interstitial non-granular cells, strongly PAS-positive angular bodies were seen. The ultrastructural and immunohistochemical findings indicate that these granular cells are of neurogenic in origin.
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Hideki Takemura, Tetsuaki Kubota, Kazuo Matsui, Masaki Iida, Dai Nagas ...
2002 Volume 2002 Issue Supplement109 Pages
86-90
Published: December 10, 2002
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We report two cases of laryngeal hemangioma. The first case was a 32-year-old female. She complained of dyspnea while lying down and an abnormal sensation on swallowing. From the laryngoscopic findings showing a large dark red tumor located from the right false vocal cord to the piriform recess, we suspected laryngeal hemangioma. After MRI, angiography and embolization, we resected the tumor by lateral pharyngotomy with a tracheotomy. The second case was a 19-year-old male complaining of a swollen neck and an abnormal sensation in the larynx. He also had a large hemangioma located from the right false vocal cord to the pharynx beyond the piriform recess. His tumor was resected by the same method. Both tumors were revealed to be cavernous hemangioma by histological examination. Although several treatment methods for laryngeal hemangioma are known, it is preferable for a large tumor to be resected by lateral pharyngotomy or lateral laryngotomy, becouse it can be resected more safety under a wide view.
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Hideki Takemura, Tetsuaki Kubota, Kazuo Matsui, Dai Nagase, Hajime Han ...
2002 Volume 2002 Issue Supplement109 Pages
91-97
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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Because traffic accident trauma of the larynx cause variable changes depending on the degree and region of injury, it is difficult to decide on a method of treatment for each patient. In this case, we treated a 69-year-old woman with severe laryngeal stenosis. After we recognized by 3-D imaging that her thyroid cartilage was broken and displaced, we performed laryngoplasty, but granulation and stenosis soon recurred. We performed laryngo-micro surgery (LMS) with a CO
2 laser three times, inserting a T-tube into her larynx at the 2nd and 3rd LMS, but the disease recurred again. We performed laryngoplasty once again and inserted another type of T-tube for three months. With this procedure we succeeded in establishing a sufficient airway and functional voice almost without aspiration.
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Hideaki Moteki, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Hajime ...
2002 Volume 2002 Issue Supplement109 Pages
98-101
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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Relapsing polychondritis (RPC) is a disorder characterized by inflammation and the destruction of the cartilaginous structures of multiple organs. The typical diagnostic signs are auricular chondritis, nasal chondritis, respiratory tract chondritis and audiovestibular damage, therefore RPC is an important disorder for laryngologists. In particular, tracheal stenosis due to chondritis is the main cause of death.
We present two cases of RPC, comfirmed by diagnostic signs recognized by Damiani's expanded criteria for diagnosing RPC.
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Hajime Hanaoka, Tetsuaki Kubota, Kazuo Matsui, Kazumasa Ohashi, Yoshiy ...
2002 Volume 2002 Issue Supplement109 Pages
102-104
Published: December 10, 2002
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A case of radiation necrosis of the larynx is reported. A 68-year-old man suffered from cancer of the larynx, and 20 years ago, he was treated with radiation. He complained of increasing throat pain, and was suspected of having radiation necrosis of the larynx.
Antibiotics and steroids were administered, but the radiation necrosis was exacerbated. We recommended surgery but he refused and later become DIC and died. Once necrosis of the cartilage occurs, a laryngectomy is required.
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Takashi Ohtani, Tetsuaki Kubota, Genjiro Miyao, Souta Takasaki
2002 Volume 2002 Issue Supplement109 Pages
105-107
Published: December 10, 2002
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A 10-year-old boy presented with a 3-week history of a tumor on the tongue with bleeding. The tumor was blue in color covered by normal tongue tissue. There was a lymphnode (1 cm×1 cm) palpable in the right deep upper neck. The tumor was excised with surrounding normal tissue. It was identified as an acinic cell tumor by pathologic study. The cervical lymphnode was resected, and there was no evidence of metastasis. This was a rare case, the youngest and only the 3rd case of a tongue tumor in the literature of Japan.
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Masao Kasuga, Tetsuaki Kubota, Kazuo Matsui, Kazumasa Ohashi, Yoshiyuk ...
2002 Volume 2002 Issue Supplement109 Pages
108-111
Published: December 10, 2002
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Undifferentiated carcinoma of the minor salivary gland is a rare malignant tumor. A case of undifferentiated carcinoma arising in the minor salivary gland is reported. A 56-year-old male consulted our hospital with a left buccal tumor and cervical lymph nodes. The left buccal tumor was resected and neck dissection was performed. Pathological examination confirmed the diagnosis of undifferentiated carcinoma with buccal tumor and cervical lymph node metastasis. Postoperative radiation therapy and chemotherapy (CDDP + 5FU) was performed, however, metastasis to the skin occurred two years after surgery, and although additional radiation therapy was administered, he died.
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Sei Kobayashi, Kazuo Matsui, Dai Nagase, Hideki Takemura, Tetsuaki Kub ...
2002 Volume 2002 Issue Supplement109 Pages
112-115
Published: December 10, 2002
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Acinic cell carcinoma is a relatively rare and low grade malignant tumor of the parotid gland. From April 1991 to April 2000, we treated two acinic cell carcinomas of the parotid gland in the deep lobe.
Preoperation we expected to find benign tumors but they were acinic cell carcinomas. We performed a total parotidecomy and the preserved facial nerve, and in addition, we carried out radiotherapy. There has been no metastasis or recurrence, but we need to follow them long term.
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Focussing on Frey's Syndrome
Sei Kobayashi, Kazuo Matsui, Hideki Takemura, Tetsuaki Kubota
2002 Volume 2002 Issue Supplement109 Pages
116-118
Published: December 10, 2002
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We treated 92 patients with parotid gland tumors from 1989 to 2000. Seventy-four tumors were benign and 18 were malignant. We requested follow-up information about them and the rate of collection was 60% (55 patients).
Facial nerve palsy occurred in 10 patients,5 patients had benign tumors, and Frey's syndrome occurred in 17 patients. However, there were only 5 of 32 patients who were covered with superiorly based muscular flaps from the sternocleidomastoid.
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Masako Inoue, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Hajime H ...
2002 Volume 2002 Issue Supplement109 Pages
119-123
Published: December 10, 2002
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We report a case of giant parathyroid adenoma.
A 64-year-old female was admitted to the hospital because of bilateral thighbone fractures and high blood Ca. Her blood Ca level was 11.8 mg/ml and intact-PTH was 1424 pg/ml. Her blood ALP level and c-PTH were also high. An x-ray film of the chest showed displacement of the trachea. CT and MRI films of the chest and neck showed a solid, smooth tumor located in the right upper mediastium of the neck. MIBI scinti showed abnormal accumulation along the side of the tumor site in CT and MRI. The patient was diagnosed with primary hyperparathyroidism due to the parathyroid tumor. The tumor was excised from the neck without mediastinotomy. It was a parathyroid tumor 75 g in weight and 6.0×5.0×5.0cm, the location coinciding with the CT and MRI films. Pathologically, it was diagnosed as parathyroid adenoma. After the operation, the blood Ca level and PTH fell to within the normal range and her general condition improved.
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Dai Nagase, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Hajime Han ...
2002 Volume 2002 Issue Supplement109 Pages
124-129
Published: December 10, 2002
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Most cases of primary hyperparathyroidism are a single adenoma and double parathyroid adenomas are rare. If two swollen glands are detcted at the back of the thyroid lobes, we consider that the cause of the primary hyperparathyroidism is double parathyroid adenomas or hyperplasia. Recently, we treated two cases of double parathyroid adenomas. Two swollen glands were removed, and the values of serum calcium and parathyroid hormone were normalized after surgical treatment. These cases are discussed with reference to the procedures of preoperative diagnosis and surgery.
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Yoshiyuki Kadokura, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Se ...
2002 Volume 2002 Issue Supplement109 Pages
130-134
Published: December 10, 2002
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The surgical outcomes of 70 cases of secondary hyperparathyroidism due to chronic renal failure are reported and the operation procedure disscussed.
It is a surgical principle that all of the four parathyroid glands must be examined without reference to the preoperative diagnosis.
It was important that the surgeon was familiar with the normal anatomy and the variations of parathyroid glands.
The surgery was successful in 63 cases (90%).
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Hajime Hanaoka, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Masaki ...
2002 Volume 2002 Issue Supplement109 Pages
135-139
Published: December 10, 2002
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Parathyroid carcinoma is relatively rare. A 48-year-old male was referred to the hospital complaining of a front neck tumor. Multiple tumor lesions were detected in the chest X-P. He was then examined at our hospital. Hyperparathyroidism was suspected from the laboratory data including hypercalcemia and a high PTH level. A neck CT showed a right frontal neck mass invading the trachea and superior mediastium. A chest CT showed multiple pulmonary metastases. He underwent en bloc resection of the parathyroid carcinoma with part of the trachea. After surgery, he was treated with chemotherapy and radiation for multiple pulmonary metastases. The calcemia and PTH level dropped for a while, but gradually increased. An MRI showed brain metastasis and he was treated with y-knife. He underwent resection of the pulmonary metastases and was treated with alcohol injection therapy for multiple metastases. At present, the calcemia and PTH are slightly high, and he has been followed up without symptoms.
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Masao Kasuga, Tetsuaki Kubota, Kazuo Matsui, Dai Nagase, Takayuki Ota, ...
2002 Volume 2002 Issue Supplement109 Pages
140-143
Published: December 10, 2002
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We experienced a case of oxyphilic cell follicular carcinoma of the thyroid gland. A 48-year-old male consulted our hospital with a neck tumor. CT revealed a tumor in the left lobe of the thyroid. After admission, the tumor was resected. Pathological examination confirmed the diagnosis of oxyphilic cell follicular carcinoma of the thyroid gland. This rare case is reported.
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Yoshihiro Yamada, Kazuo Matsui, Masao Kasuga, Yoshiyuki Kadokura, Haji ...
2002 Volume 2002 Issue Supplement109 Pages
144-147
Published: December 10, 2002
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Three patients with malignant lymphoma of the thyroid gland were treated at Showa University Hospital: 1 female and 2 males. We performed fine needle aspiration (FNA) in all patients, all of whom were diagnosed. Ultrasound or CT was also very useful to detect and diagnose malignant lymphoma of the thyroid gland. Ga scintigraphy before treatment showed intense uptake in thyroid gland. The treatment strategy mainly consisted of radiation and chemotherapy. It is very important for early diagnosis to consider this disease in the differential diagnosis.
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Satoshi Naitoh, Kazuo Matsui, Hisahi Ohtani, Souta Takasaki, Hideki Ta ...
2002 Volume 2002 Issue Supplement109 Pages
148-152
Published: December 10, 2002
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We encountered 6 patients with undifferentiated carcinoma of the thyroid gland over 9 years. In cases 1,2 and 3, the tumors were anaplastic and infiltrated surrounding tissues as well. In their operations, the tumors were excised as much as possible and the removed tissue was found to be undifferentiated carcinoma within differentiated carcinoma. A few years later, all three of them were found with lung metastasis, which was the cause of their deaths. In cases 4 and 5, the patients were already in severe condition at first visit, and both lived for only a short while. Even though the tumor in case 6 was very large, it was localized. After 67.2 Gy of radiotherapy and 2 times of each CDDP, ADM, and VP-16 chemotherapy, the tumor was necrosed. The patient in case 6 has no recurrence and is still alive. From this case, we predict a good prognosis for localized tumors treated with combination therapy. It is important that a rapidly enlarging thyroid tumor be diagnosed several times by fine needle biopsy if undifference is suspected.
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Hajime Hanaoka, Tetsuaki Kubota, Kazuo Matsui, Kazumasa Ohasi, Tatsuya ...
2002 Volume 2002 Issue Supplement109 Pages
153-156
Published: December 10, 2002
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Two cases of tumor in the front neck are reported. The first case, a 20-year-old male, had a tumor in the right front neck and a histological examination revealed a teratoma. The second case, a 68-year-old female, had a tumor in the left front neck and a histological examination revealed an inverted thymoma. At the time of the first medical examination, we suspected a thyroid gland tumor. Before surgery, we were not able to make a definite diagnosis, which was only confirmed after the operation.
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Masahiro Katsuno, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Haji ...
2002 Volume 2002 Issue Supplement109 Pages
157-160
Published: December 10, 2002
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Cervical cystic lymphangioma (hygroma) usually occurs in infants under two years old, but it is rarely found in adults. We report a rare case of cystic lymphangioma arising in the left lateral neck of a 47-yearold female. We resected a huge tumor,19×12×10 cm,1130 g weight. This is the biggest tumor in the reports of adult lympangioma in Japan. No recurrence has been noted to date.
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Hajime Hanaoka, Tetsuaki Kubota, Kazuo Matsui, Yoshiyuki Kadokura, Mas ...
2002 Volume 2002 Issue Supplement109 Pages
161-163
Published: December 10, 2002
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A 42-year-old man was admitted due to advanced nasopharynx cancer and administered a total dose of 19250 mg 5-fluorouracil (5-FU). On the fifth day, he exhibited acute consciousness disturbance, and the 5-FU administration was immediately stopped. An MRI revealed a high intensity lesion on the T2weighed image. The brain disease improved gradually. We do not have an effective cure for this disease but it must be detected early.
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Sei Kobayashi, Hajime Hanaoka, Dai Nagase, Yoshiyuki Kadokura, Kazuo M ...
2002 Volume 2002 Issue Supplement109 Pages
164-166
Published: December 10, 2002
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A case of branchiogenic carcinoma is reported. The patient was a 62-year-old woman who noticed a mass on the left neck and visited our hospital. CT and MRI revealed a cystic lesion and the tumor was revealed to be malignant by fine needle biopsy. We diagnosed the tumor as an unknown primary tumor and performed a radical neck dissection. The histopathological diagnosis was squamous cell carcinoma arising from the epithelial lining of a cystic lesion. There has been no recurrence but we must follow up this case long term.
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Yoshiyuki Kadokura, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Da ...
2002 Volume 2002 Issue Supplement109 Pages
167-171
Published: December 10, 2002
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This is an analysis of 21 patients (16 males,5 females; age range 21 to 90 years, with an average of 56 years) with metastatic cancer from unknown primary sites, treated in our department between 1985-2000. Four of these patients were Ni,15 were N2 and 2 were N3. The histopathological diagnosis was SCC in 20 cases and adenocarcinoma in 1 case. The 10-year survival rate was 66.9%.
Irradiation, including the nasopharynx and whole neck following a radical neck dissection is recommended for metastatic cancer from unknown primary sites.
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Yoshiyuki Kadokura, Tetsuaki Kubota, Kazuo Matsui, Hideki Takemura, Ma ...
2002 Volume 2002 Issue Supplement109 Pages
172-176
Published: December 10, 2002
Released on J-STAGE: November 27, 2012
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14 patients with advanced or recurrent head and neck cancer (stage III, IV) were treated by superselective intra-arterial infusion chemotherapy with or without irradiation. The tumor locations included nasopharynx (n=4), mesopharynx (n=5), oral cavity (n=2), maxillary sinus (n-=1), tongue (n=1) and larynx (n=1).
For the chemotherapy,80-100 mg/m
2 of CDDP or CDGP was administered through the tumor feeding artery at a rate of 6 mg/min.
The complete and p a rtial response rates were 8/14 (57%),3/14 (21%), respectively.
We expect that follow-up observation over an extended time will provide m eaningful information.
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