巻号一覧
43 巻, 2 号
選択された号の論文の11件中1～11を表示しています
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1: マグネットリポソームの作製と培養細胞に対する影響神部 芳則, 赤坂 庸子, 伊藤 弘人, 東 陽子, 辻村 範行, 松永 是1997 年 43 巻 2 号 p. 55-61
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーThe authors attempted to develop a new cancer chemotherapy with magnetoliposomes containing CDDP for the treatment of head and neck squamous cell carcinoma. First, preparations of magnetoliposomes containing CDDP and the effects of these liposomes on cultured tumor cells were examined. Magnet particles were purified from Magnetspillium sp. AMB-1. These particles and CDDP were incorporated into liposomes prepared with phosphatidylcholine and cholesterol. The antitumor activity of the magnetoliposomes against mouse squamous cell carciroma (KLN250 cells) was evaluated by an XTT assay. Magnetoliposomes containing CDDP showed distinct cytotoxic activity against KLN205 cell at the concentration of 5 μg CDDP/ml. At this concentration of CDDP, there was no cytotoxic activity of CDDP alone. The results suggest that magnetoliposomes containing CDDP may be an effective drug delivery system for cancer treatment. Magnetoliposomes can remain around tumor cells for prolonged periods by application of an external magnet field, and CDDP can be released slowly and continuously.抄録全体を表示PDF形式でダウンロード (3408K) -
楠川 仁悟, 亀山 忠光, 豊福 司生, 田中 俊一, 中村 芳明1997 年 43 巻 2 号 p. 62-70
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーAmong 221 patients with primary oral SCCs, 18 (8.1%) had late recurrence at the primary site from 36 to 175 months after the initial treatment. Late recurrence of oral carcinomas was evaluated clinicopathologically, and the following results were obtained:
1) Late recurrence occurred at a significantly higher incidence in T 1 tumors than T 2-4 tumors.
2) As for the clinical growth pattern, superficial type primary tumors were more likely to have late recurrence than exophytic or endophytic type (p>0.05).
3) There was no difference in late recurrence rate between patients who received chemotherapy and those who received no chemotherapy. Among 69 patients who received radiation, radiation-induced oral carcinoma occurred in 1 patient (1.4%), 11 years after radiotherapy.
4) Histopathologically, the degree of differentiation and mode of invasion, were similar for primary and recurrent lesions.
5) Late recurrence occurred in tumors associated with epithelial dysplasia (13/71 cases, 18.3%) at a significantly higher rate than those lacking epithelial dysplasia (3 /105 cases, 2.9%). Epithelial dysplasia adjacent to carcinoma was also observes in 93.8% of primary lesions with late recurrence.
6) Margin status was an important factor affecting lacal recurrence rate but not late recurrence rate.
7) Among the 18 primary tumors with late recurrence, tumor suppressor gene, p53, was detected in 50% of primary carcinomas, 26.7% of dysplasia, and 11.1% of normal epithelium.
These results suggest that late recurrence is a de novo carcinoma caused by field cancerization. Epithelial dysplasia adjacent to cancer is an important factor in predicting late recurrence of oral carcinomas. Thus, long-term follow-up is necessary for such patients, even when primary tumors are small and completely resected.抄録全体を表示PDF形式でダウンロード (4147K) -
遊佐 浩, 吉田 廣, 植野 映1997 年 43 巻 2 号 p. 71-78
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーThis study was conducted to establish objective criteria for the ultrasonographic diagnosis of cervical metastatic lymph nodes (LNs). Materials consisted of 106 LNs removed from 41 patients with squamous cell carcinoma of the oral and maxillofacial region. These LNs were ultrasonographically and histologically examined. B-mode ultrasonograms revealed statistically significant differences in the depth, width, depth and width ratio, edge definition, margin, intensity and heterogeneity of internal echoes, and nodal hilus between the metastatic and the non-metastatic LNs. Color Doppler echograms obtained from 31 of the 106 LNs showed a peripheral perfusion pattern in many metastatic LNs, whereas a central perfusion pattern was seen in many non-metastatic LNs. To ultrasonographically establish objective criteria for metastatic LNs, the correlation between the B-mode ultrasonographic findings and histologic features was analyzed for all LNs. The following regression equation was calculated by multiple logistic regression analysis. Y=1/1+e-λ (Y: metastasis, λ: predictive value=-7.5709+4.2423X1+1.9354X2 +0.5507X3, X1: nodal hilus, X2: intensity of internal echoes, X3: depth).
This equation showed that the sensitivity, specificity, and accuracy, for the metastatic LNs were 82.1%, 92.5%, and 88.7%, respectively. The results suggested that this equation is valuable in the ultrasonographic prediction of metastatic LNs.抄録全体を表示PDF形式でダウンロード (3707K) -
ラット移植骨の形態学的, X線学的, 組織学的変化岩田 雅裕1997 年 43 巻 2 号 p. 79-85
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーAttention has focused on fetal tissues in recent years as cellular grafting material for patients with parkinsonism, diabetes, and other diseases, whereas no study has reported the use of fetal bone tissue for bone grafting. I noted that fetal bone has low antigenicity and has growth potential. Thus, I performed two-step grafting of fetal bone. In the present study, I carried out experimental primary grafting with fetal tibia as the first stage of this study design and evaluated the possibility of using fetal bone as bone grafting material. As donor, fetuses were removed by cesarean section from Lewis rats on the 17th day of pregnancy. Disarticulation was performed under an operating microscope, and the tibia was collected. Fischer and Brown-Norway rats were used as recipients, and the tibia was grafted to the back. The graft was collected at the 1st, 2nd, 3 rd, and 4 th weeks after grafting, and the longer axis was measured. Further more, histopathlogical and radiological examinations were performed. Growth of the graft bone over time was macroscopically, histologically, and radiologically confirmed at the subcutaneous site of primary grafting. The longer axis was 2.36±0.13 mm when the tibia was collected from the fetus. After grafting, it increased with time to 12.40±2.50 mm at the 4 th week, equivalent to an increase of 5.25 times. In both recipient rats, the longer axis increased, and there was no difference between two types of rats. I conclude that fetal bone has low immunogenicity and is useful as allogenic bone grafting material in the early stage of primary grafting.抄録全体を表示PDF形式でダウンロード (5798K) -
山田 健久, 澤木 佳弘, 藤内 祝, 竹内 学, 上田 実1997 年 43 巻 2 号 p. 86-89
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーWe examined the relation between the incidence of mandibular angle fractures caused by sports activities and the presence and status of the mandibular third molars. The sample for the primary study consisted of 30 patients with sports-related mandibular fractures. Their medical records and panoramic radiographs were studied retrospectively. The presence and degree of impaction of the mandibular third molars were assessed. The sample for the second study consisted of 63 healthy rugby players. Their mandibular third molars were classified and assessed by the same measures.
The incidence of angle fractures was found to be significantly higher in patients with third molars than in those without third molars (p<0.05).
Although there were no significant differences between the degree of impaction and angle fractures, the latter tended to occur in the group with a higher impaction score. The proportion of rugby players with third molars was significantly higher than the proportion without third molars (p<0.001). A high proportion of the young athletes (75.5%) was considered to belong to the high risk group.
This study suggests that mandibular angle fractures due to sports-related injuries are influenced by the presence and status of the third molars. We recommend the removal of mandibular third molars in young athletes in the high risk group.抄録全体を表示PDF形式でダウンロード (413K) -
早津 良和, 岡藤 正樹, 石丸 孝則, 水柿 雄三, 平木 雄三郎, 福田 てる代, 篠崎 文彦1997 年 43 巻 2 号 p. 90-93
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーAt the Department of Oral and Maxillofacial Surgery, Yamaguchi University Hospital, 43 tracheotomies were performed between 1985 and 1994.
Tracheotomies were classified as elective or emergency. Elective tracheotomies were performed in 37 cases (86.0%) and emergency tracheotomies in 6 cases (14.0%). The elective tracheotomies included 34 cases of oral cancer, 2 cases of multiple fractures of the jaws, and 1 case of benign tumor. Of these 34 cases of oral cancer, 17 underwent total or subtotal resection of maxilla, and 16 underwent immediate reconstruction with a pectoralis major myocutaneous flap after the resection of oral cancer.
Six emergency tracheotomies were performed in patients with advanced oral cancer because of obstruction of the upper respiratory track or bleeding from the mouth or cervical region.
The duration of intubation ranged from 3 to 214 days, with an average of 23.8 days. The tubes were used up to 10 days in 25 cases (58.1%).
No serious complications occured during the operative or the early and late postoperative phases after tracheotomy.抄録全体を表示PDF形式でダウンロード (552K) -
新谷 悟, 寺門 永顕, 井上 正久, 衛藤 洋平, 永井 教之, 松村 智弘1997 年 43 巻 2 号 p. 94-96
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーA number of studies have suggested that histological grading of biopsy specimensof tumors might be a valuable prognostic indicator for oral cancers. This study examined the relationship between the tumor histological grade of biopsy specimens and that of resected specimens obtained from 32 patients with oral squamous cell carcinomas who received no preoperative treatment. Differences between biopsy and resected specimens were found with respect to differentiation in 13 of 32 cases (40.6%), mitosis in 7 /32 (21.9%), nuclear atypism in 6 /32 (18.8%), mode of invasion in 16/32 (50.0%) and lymphocyte infiltration in 3 /32 (9.4%). In tongue carcinoma, the differentiation of the resected specimens was higher than that of the biopsy specimens. In about half of the cases, the mode of invasion of the resected specimens was 1 grade higher than that of the biopsy specimens. This tendency was strongest for cases with an advanced T stage.抄録全体を表示PDF形式でダウンロード (5471K) -
吉田 博昭, 藤田 茂之, 横田 幸治, 西田 光男, 村上 賢一郎, 飯塚 忠彦1997 年 43 巻 2 号 p. 97-99
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーMatrix metalloproteinases (MMPs) can degrade various kinds of extracellular matrices (ECM) and are thought to play an important role in the degradation of ECM in various diseases.
In this study, we analyzed immunohistochemically MMP-3 localization in the temporomandibular joint (TMJ) disc of a patient with painful closed lock and a patient with osteoarthrosis.
MMP-3 showed two patterns in staining profile. In the first type, diffuse staining was observed within the disc deformed by osteophytes. In the other type, limited staining was observed on the severely hypertrophic synovial membrane.
These findings suggest that MMP-3 is distributed in the destructed TMJ disc and synovial membrane.抄録全体を表示PDF形式でダウンロード (3382K) -
内田 暢彦, 武藤 壽孝, 道谷 弘之, 冨岡 敬子, 川上 譲治, 小西 亮, 江上 史倫, 金澤 正昭1997 年 43 巻 2 号 p. 100-102
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーWe report on two patients in whom the mandible was immediately reconstructed with the anterior part of the ipsilateral ascending ramus.
The first patient, who had cemento-ossifying fibroma, received segmental resection and the second patient, who had ameloblastoma, received marginal resection. We followed up these cases from 4 years to 6 years after surgery. Radiographically, a good shape of the mandible was preserved in both patients.
Clinically, they had a sufficient alveolar ridge wearing dentures, and there was no cosmetic problem.抄録全体を表示PDF形式でダウンロード (5590K) -
竹村 日登美, 平野 吉子, 小原 浩, 西尾 順太郎1997 年 43 巻 2 号 p. 103-105
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーOccasionally an unerupted tooth moves to a location that is some distance from the site from which it arose. This is often caused by the force of a tumor or a cyst, but sometimes the mechanism of the movement cannot be identified. We report the case of a 15-yearold girl in whom an unerupted mandibular first premolar moved below the coronoid process because of no apparent cause. A dental radiograph taken at the age of 9 years showed that the tooth germ of 7 was located in normal position and it appeared to be erupting. However, a panoramic tomogram taken at the age of 12 years showed that F4 was located in a horizontal position below the second molar. The unerupted first premolar continued distal movement, and 3 years later it had migrated below the coronoid process. During the 6 years, it appeared to have slowly moved a distance of about 6cm. No symptoms related to the tooth have developed.
We speculate that the movement was caused by rupture of the gubernacular cord, early loss of deciduous teeth, hypodontia, microdontia, or other factors.抄録全体を表示PDF形式でダウンロード (2858K) -
光本 和世, 角田 左武郎, 山口 真吾, 鈴木 里咲, 岩瀬 正泰, 南雲 正男1997 年 43 巻 2 号 p. 106-108
発行日: 1997/02/20
公開日: 2011/07/25
ジャーナル フリーWe describe a patient in whom calcification occurred around silicon implanted into the cheek to reconstruct a tissue defect caused by noma 35 years previously.
A 50-year-old woman visited our department because of a swelling of the left cheek and severely limited mouth opening. A computed tomographic scan revealed the presence of an implant, about 3cm in diameter, surrounded by calcified tissue in the left cheek. The impant was removed surgically and analyzed by scanning electron microscopy (SEM) and an X-ray microanalyzer. SEM showed that calcification occurred in the connective tissue surrouding the implant. At higher magnification, the calcification sites showed a globular structure. The major mineral components of the globular structures were calcium and phosphate. The molecular ratio of calcium and phosphate was 1.67±0.052, which was similar to that of hydroxyapatite.抄録全体を表示PDF形式でダウンロード (2891K)
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