巻号一覧
52 巻, 9 号
選択された号の論文の7件中1～7を表示しています
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尾島 泰公, 梅田 正博, 小松原 秀紀, 南川 勉, 渋谷 恭之, 横尾 聡, 古森 孝英2006 年 52 巻 9 号 p. 474-479
発行日: 2006/09/20
公開日: 2011/04/22
ジャーナル フリーA clinicopathological study was made of 49 patients with squamous cell carcinoma of the upper gingiva between 1980 and 2002, and the following findings were obtained.
1) The initial therapy was surgery in 45 patients (34 with an intraoral approach and 11 with an extraoral approach), trimodal combination therapy (external irradiation, per-gingival maxillary sinus surgery, and regional intra-arterial infusion chemotherapy) in 3, and radiotherapy alone in 1. Local cure was obtained in 46 (93.4%) of the 49 patients.
2) Twelve patients (40.8%) had histologically confirmed cervical lymph node metastasis. The most frequent site of metastasis was level II of the neck, especially in patients who had posterior invading cancer.
3) The overall 5-year cumulative survival rate was 74.6%. Three patients died of local failure, 4 of neck failure, 3 of Rouviere lymph node metastasis, and 4 of distant metastasis.
4) Patients with lymph node metastasis in the level II of the neck, contralateralneck metastasis, or Rouviere lymph node metastasis had extremely poor outcomes.
5) Rouviere lymph node metastasis should be taken into consideration in patients who have posterior invading cancer and lymph node metastasis in level II of the neck.抄録全体を表示PDF形式でダウンロード (1946K) -
第3報2回顎関節腔洗浄療法 (ステロイド注入), 消炎鎮痛剤投与および開口練習併用療法脇田 壮, 栗田 賢一, 小木 信美, 清水 幹雄, 鍋島 弘充, 矢島 哲弥, 町田 純一郎, 中塚 健介, 佐藤 春樹, 中島 克仁2006 年 52 巻 9 号 p. 480-488
発行日: 2006/09/20
公開日: 2011/04/22
ジャーナル フリーArthrocentesis is the surgical treatment of choice for TMJ disorders. Many studies of arthrocentesis have been performed, with excellent clinical outcomes. No previous study has used multiple arthrocenteses to treat the dysfunctional TMJ. This study evaluated the efficacy of two consecutive arthrocenteses (steroid injection) followed by mouth-opening exercises during non-steroidal anti-inflammatory drug (NSAID) administration as a primary treatment for TMJ osteoarthritis.
Subjects in this study were selected from a consecutive series of new patients with unilateral moderate to severe TMJ dysfunction at TMD Clinic, Aichi-Gakuin University Hospital during a year. Twenty-eight patients with MRI documentation of osteoarthritis underwent two consecutive arthrocenteses with steroid injection at a 2-week interval followed by mouth-opening exercises and treatment with the NSAID, Etodolac. The patients were postoperatively examined every 2weeks for 12weeks. The patients were clinically evaluated on the basis of visual analog scales (0-100) and the range of motion. Factors that affected the clinical outcome of TMJ function were assessed.
Of the 28 patients who underwent two consecutive arthrocenteses, 21 (75%) showed substantial improvement on follow-up at 12weeks. The range of motion (median) increased from 28mm to 41mm. Visual analog scale pain-scores on mouth opening and chewing significantly decreased from 50 and 60 to 24 and 22, respectively. The disturbance score for activities of daily life also decreased from 55 to 18. A longer duration of TMJ symptoms before the procedure was found to affect outcome.
This combination therapy is an effective primary treatment for TMJ osteoarthritis.抄録全体を表示PDF形式でダウンロード (1821K) -
堀眞 由美, 笹倉 裕一, 三好 代志子, 上村 博司, 渡邉 是久2006 年 52 巻 9 号 p. 489-497
発行日: 2006/09/20
公開日: 2011/04/22
ジャーナル フリーTelomerase activity is detected in most malignant human tumors, but not found in normal somatic cells except for a few cell lines. Telomere is located on the end of eukaryotic chromosomes and must be of sufficient length to ensure chromosome stabilization. It is hypothesized that the reactivated enzyme, telomerase, in malignant tumors maintains the telomere length towards attrition during cell replication. In contrast, normal somatic cells are terminated by one of thep53 functions caused by signals promoting a critically shortened telomere region. In this study, wild typep53 gene was introduced into a head and neck squamous cell carcinoma (HNSCC-2p) cell line by a lipofectin method. We examined whether wild typep53 plays a role in regulating telomerase activity, human telomerase reverse transcriptase (hTERT) protein production, and hTERT mRNA expression. The cells, which were derived from a tongue squamous cell carcinoma, had two point mutations ofp53 and telomerase activity. Telomerase activity, hTERT mRNA expression, and hTERT production as protein were examined by telomerase repeat amplification protocol (TRAP), reverse transcriptase (RT)-PCR, and Western blotting, respectively. Telomerase activity, hTERT mRNA expression, and hTERT showed a down-regulation 24 and 48 hours after wild type p53 introduction. These data suggest that wild typep53 down-regulates telomerase activity and hTERT production as protein by repressing hTERT transcription.抄録全体を表示PDF形式でダウンロード (2923K) -
宮原 麻由美, 田沼 順一, 松井 竜太郎, 國芳 秀晴, 仙波 伊知郎, 杉原 一正2006 年 52 巻 9 号 p. 498-501
発行日: 2006/09/20
公開日: 2011/04/22
ジャーナル フリーCombined epithelial odontogenic tumor was first described by Damm in 1982 as a rare tumor characterized by the presence of calcifying epithelial odontogenic tumor (CEOT) areas in adenomatoid odontogenic tumor (AOT). Histologically, the tumor shows relatively small epithelial nests forming duct-like structures and markedly hyalinized fibrous tissue stroma containing amorphous and irregularly shaped calcified tissue and amyloid-like materials. There are several round-shaped masses that show Liesegang rings. This article describes a case of adenomatoid odontogenic tumor with calcifying epithelial odontogenic tumor-like areas, so-called combined epithelial odontogenic tumor, between the right lateral incisor and the left canine region in the mandible.
A 27-year-old woman was referred to our clinic for evaluation of a mixed radiolucent-radiopaque lesion with a well-defined border in the mandible. A computed tomographic scan demonstrated a well-defined large lesion that extended widely, with thinning of the cortical bone of the mandible. The lesion was associated with an impacted canine in the mandible.
Surgery was performed with the patient under general anesthesia.The tumor was enucleated completely via an intraoral approach. Wound healing is currently good, 9 months after surgery.抄録全体を表示PDF形式でダウンロード (4131K) -
山中 喜代, 平島 惣一, 冨永 和宏, 福田 仁一, 張 皿, 福山 宏2006 年 52 巻 9 号 p. 502-506
発行日: 2006/09/20
公開日: 2011/04/22
ジャーナル フリーLymphoepithelial cyst is characterized by a cyst wall, the inner layer of which consists mainly of squamous epithelium, overlying lymphatic tissue. Previously, this lesion has been referred to as a branchiogenic cyst, lateral cervical cyst, or benign lymphoepithelial cyst. This lesion frequently develops in the lateral cervical region or oral floor, but rarely develops in the parotid gland.
We report on a 68-year-old man with a lymphoepithelial cyst in the parotid gland, which showed changes on MRI before operation. With the patient under general anesthesia, the lesion was extirpated. Histopathologically, the resected specimen suggested a lymphoepithelial cyst. Because the cyst contained a colloid substance, transformation of a liquid substance into a highly viscous colloid substance may have contributed to the changes on MRI. Many duct-like structures of the salivary gland were observed in the resected specimen, suggesting that the content was initially similar to saliva, and that these ducts were involved in subsequent changes in the liquid content. Furthermore, a lymphatic tissue layer with a marginal sinus-like structure was found below the capsule. Therefore, we speculated that the parotid glandular epithelium invaded the parotid lymph nodes, leading to cyst formation.抄録全体を表示PDF形式でダウンロード (3891K) -
真野 隆充, 内田 堅一郎, 岡藤 正樹, 堀永 大樹, 長塚 仁, 上山 吉哉2006 年 52 巻 9 号 p. 507-510
発行日: 2006/09/20
公開日: 2011/04/22
ジャーナル フリーMucinous adenocarcinoma (MAC) arising in the oral cavity is extremely rare. We report a case of MAC originating in the palate.
A 70-year-old man presented with an ulcer of the palate visited our hospital. A demarcated tumor arising in the right side of the palate with cervical lymph swelling on the same side were recognized. Histopathological examination revealed a MAC. Partial maxillectomy and radical neck dissection were immediately performed. After surgery, neck metastasis was detected on the contralateral side. Radical neck dissection was therefore performed. After that, recurrence in the right side of the neck and lung metastasis was detected. Bilateral radiotherapy was given to treat recurrence in the neck, and chemotherapy was administered to treat the lung metastasis. The patient died of respiratory insufficiency 2 years 5 months after the first examination.抄録全体を表示PDF形式でダウンロード (2884K) -
上原 忍, 栗田 浩, 成川 純之助, 酒井 洋徳, 鎌田 孝広, 倉科 憲治2006 年 52 巻 9 号 p. 511-514
発行日: 2006/09/20
公開日: 2011/04/22
ジャーナル フリーBacterial aneurysm of the common carotid artery is rare. Septicemia, dental infection, postoperative infection, and endocarditis are thought cause this disease. In this paper, we describe a case of a common carotid artery bacterial aneurysm caused by neck lymphadenitis.
A 49-year-old man was referred to us for treatment of pain in the third molar region of the left side of the mandible and swelling and pain in the left side of the neck. After the symptoms resolved in response to antibiotic chemotherapy, we extracted the left lower second molar and impacted third molar. Twelve days after, he visited our hospital again because of swelling in the left side of the neck. Pulsation could be noted on the swelling. The white blood cell count was 14880/ml, and the C-reactive protein level was 10.77mg/dl. A CT scan revealed a pseudoaneurysm of the left common carotid artery. He was referred to neurosurgeons and received a diagnosis of aneurysm of the common carotid artery caused by bacterial infection, judging from the clinical course. Antibiotics were administered for 6 weeks. After the inflammation resolved, he underwent common carotid-internal carotid artery bypass. Histopathologically, the diagnosis was bacterial aneurysm caused by neck lymphadenitis.抄録全体を表示PDF形式でダウンロード (2936K)
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