Anti-bacterial activity of six approved drugs for ayu
Plecoglossus altivelis, i.e. florfenicol (FFC), oxolinic acid (OXA), sulfisozole sodium (SIZ), sulfamonomethoxine, ormetoprim (OMP) and sulfamonomethoxine-ormetoprim combination, was examined against four
Edwardsiella ictaluri strains. Of these drugs, FFC, OXA and OMP inhibited bacterial growth with MIC lower than 1 μg/mL. When chemotherapeutic efficacy of FFC, OXA and SIZ was examined against experimentally
E. ictaluri-infected ayu, FFC and OXA strongly reduced mortality of fish. Although SIZ was slightly effective, survivors from the SIZ-treated group showed high carrier rates for
E. ictaluri, suggesting that FFC and OXA are candidates in treating
E. ictaluri infection of ayu.
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