Many techniques have been developed to measure non-invasively ranging from physical to physiological properties of the skin i.e. mechanical, electrical, thermal, optical, photoacoustic properties, perspiration, sebum secretion, blood flow, and skin metabolic rate. They are applied to the efficacy test of cosmetic products and ingredients, or to the examination and the classification of skin condition. In this paper each method which measure skin surface topography, skin hydration, barrier function, turnover time of stratum corneum, parakeratosis, free amino acids in stratum corneum, wrinkle, spots and skin internal structure (ultrasound techniques and
in vivo confocal microscopy) is described from the standpoint of the principle and application.
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