SEISAN KENKYU
Online ISSN : 1881-2058
Print ISSN : 0037-105X
ISSN-L : 0037-105X
Volume 73 , Issue 3
Showing 1-10 articles out of 10 articles from the selected issue
Introduction to Special Section
Research Review
Research Flash
  • Jiwoo IZAWA, Byeongwook JO, Shoji TAKEUCHI
    Type: Research Flash
    2021 Volume 73 Issue 3 Pages 165-166
    Published: May 01, 2021
    Released: June 05, 2021
    JOURNAL FREE ACCESS

    In recent years, bio-assembly methods through microtissues have been highlighted in biomedical science and industry. Among various bio-assembly methods, cell fibers possess high handleability and capability of fabricating tissues on a three-dimensional scale which have potentials in such applications as bioreactors. However, due to the outbreak of Covid-19, studies on cell fibers done in laboratories are getting restricted, slowing down the development of this technology. Here we suggest a simple and cost-effective method to fabricate cell fibers at home by using a microfluidic device with double-coaxial laminar flow which is printed by a low-cost 3D printer. We also showed a demonstration of our homemade cell fibers functions as a bioreactor.

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  • Leilei BAO, Jongho PARK, Gwenaël BONFANTE, Hakjae LEE, Beomjoon KIM
    Type: Research Flash
    2021 Volume 73 Issue 3 Pages 167-170
    Published: May 01, 2021
    Released: June 05, 2021
    JOURNAL FREE ACCESS

    This paper presents a novel fabrication method of biodegradable porous microneedles (MNs) for pain-free interstitial fluid (ISF) extraction from the skin. Biodegradable polylactic acid (PLA) microspheres prepared by single emulsion were used to fill MNs in order to form continuous capillaries directly. Subsequently, heat treatment was implemented to bond microspheres together to produce interconnected micropores and robust porous structures. The results demonstrated that the extraction performance by capillary effect and skin penetration of MNs improved greatly after the heat treatment. With the proposed fabrication method, mass production of porous MNs can be achieved and furthermore, early diagnosis of diseases can be realized by integrating biosensors.

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  • Libo WU, Jongho PARK, Yuto KAMAKI, Beomjoon KIM
    Type: Research Flash
    2021 Volume 73 Issue 3 Pages 171-174
    Published: May 01, 2021
    Released: June 05, 2021
    JOURNAL FREE ACCESS

    Microneedle (MN) is a micron scale needle to bypass the stratum corneum for subsequent biomedical applications in epidermis and dermis layers of the skin. In terms of the biocompatibility and biodegradability, polylactic acid (PLA) is a safe material for MNs. In this research, PLA needles with predesigned structures were additively deposited by fused deposition modeling (FDM). Furthermore, isotropic chemical etching was employed to reduce the size of PLA needles to a micron scale to achieve the PLA MNs. PLA MNs fabricated in this work are expected to be coated with drug for medical applications.

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  • Yan CHEN, Hikari WATANABE, Marie OSHIMA
    Type: Research Flash
    2021 Volume 73 Issue 3 Pages 175-178
    Published: May 01, 2021
    Released: June 05, 2021
    JOURNAL FREE ACCESS

    Numerical blood flow simulation computes the blood flow state inside the living body by solving the governing equation of fluid dynamics and is used for diagnosis and surgical planning of vascular disease. However, because of the requirement of specialized knowledge, numerical simulation can be difficult to employ in medical practice without engineers. On the other hand, vascular networks usually have complicated anatomical structures that make it difficult for surgeon and patients to share information. In this research, we have developed a system that can dynamically remap the calculation results of 1D-0D simulation, which is a reduced dimension simulation method, to the patient-specific 3D blood vessels models and display them on the virtual reality display Oculus Rift.

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Research Review
  • Yui SASAKI, Tsuyoshi MINAMI
    Type: Research Review
    2021 Volume 73 Issue 3 Pages 179-183
    Published: May 01, 2021
    Released: June 05, 2021
    JOURNAL FREE ACCESS

    We herein report a chemosensor array for the detection of sulfur-containing amino acids (SCAAs) that play crucial roles in maintaining the homeostasis of organisms in our bodies. The chemosensor array was fabricated using two offthe-shelf coumarin dyes and a zinc(II) ion, which showed various optical changes by adding SCAAs. With pattern recognition techniques, the chemosensor array succeeded in the simultaneous multi-SCAAs recognition and the quantitative detection of SCAA in human blood serum. We believe that the proposed chemosensor array could be used as an easy-to-handle analytical method for biological samples.

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Research Flash
  • Yuya SAKAI, Ahmad FARAHANI
    Type: Research Flash
    2021 Volume 73 Issue 3 Pages 185-188
    Published: May 01, 2021
    Released: June 05, 2021
    JOURNAL FREE ACCESS

    Raw materials used for producing concrete, such as sand and gravel, are in short supply worldwide. It has been reported that the production of cement, one of the main constituents of concrete, results in the emission of a large amount of CO2, accounting for 8% of total global CO2 emissions. In this study, we developed a method to produce a construction material using only sand as the solid raw material. By utilizing a technique to produce organic silicon material from sand, we placed sand, alcohol, and catalyst in a closed vessel and heated it to 240 °C. After 24 h, the sand particles were bonded to each other, and a hardened body was formed. A tradeoff in production conditions, such as temperature, time, and the amount of sand, was confirmed.

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