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AKIRA TAHARA, TADASHI NAKATA, HIROMI NAKATANI, KAZUO KAGIWADA
1973 Volume 93 Issue 8 Pages
951-956
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Among four stereoisomers (IXa, Xa, XIa, XIIa) of hydrofluorene derivatives recently derived from pine rosin, only IXa has a strong sweetness (ca. 1000 times sweeter than sucrose and ca. 12 times bitterer than caffeine) and others have no taste. Stability and acute toxicity of IXa were also examined.
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AKIRA TAHARA, TADASHI NAKATA, YASUO OHTSUKA, SHOICHI TAKADA, TAMOTSU T ...
1973 Volume 93 Issue 8 Pages
957-963
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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A new type sweetener (X) having a hydrofluorene structure was recently found. Correlation between its sweetness and structure was studied. The improved method for its synthesis was also examined.
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GORO KOBAYASHI, YOSHIRO MATSUDA, REIKO NATSUKI, YOSHINORI TOMINAGA, TA ...
1973 Volume 93 Issue 8 Pages
964-970
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Reaction of 1-acetyl-3-hydroxy-2-(2-methoxycarbonyl-1-methylthiovinyl)indole derivatives (Ia-d) and amines afforded the corresponding amino derivatives (V and X) with 4-aminopyrano[3, 2-b]indol-2-one derivatives and 2-amino-3H-pyrrolo[1, 5-a]indol-3-one derivatives. Application of hydrazine hydrate to Id gave a compound (XII) with pyrazolone in α-position of indole. Reaction of Id with diethylamine gave 9-amino-1-methylthio 3H-pyrrolo[1, 5-a]indol-3-ones (XI), while the reaction of Ie with amines gave 1, 9-di-amino-3H-pyrrolo[1, 5-a]indol-3-one derivatives (XIVa, b).
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YOSHINORI TOMINAGA, REIKO NATSUKI, YOSHIRO MATSUDA, GORO KOBAYASHI
1973 Volume 93 Issue 8 Pages
971-976
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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1-Acetyl-3-indolinone was reacted with N-bis(methylthio)methylenebenzenesulfonamides in the presence of a base and it was found that the reaction differed accodring to reaction conditions. Reaction of 3-indolinone derivative (V, VII) with nucleophilic reagents such as amines and active methylenes afforded substitution products corresponding to the reagent used. By the use of these products, indole-condensed ring compounds, 1-(p-toluenesulfonylamino)-9-(p-toluenesulfonyloxy)pyrazino[1, 2-a]indole (IX) and 1-(p-toluenesulfonylamino)-3H-pyrrolo[1, 2-a]indol-3-one (XI), were synthesized.
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TAKASHI MATSUI, MITSUO NAGANO, JUNZO TOBITSUKA, KOZO OYAMADA
1973 Volume 93 Issue 8 Pages
977-981
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Reaction of ethyl isothiocyanatoformate (II) with o-aminobenzenethiol (Ia) affords ethyl 4-(o-mercaptophenyl)-3-thioallophanate (IIIa), which is readily converted into ethyl 2-benzothiazolecarbamate (IVa), with desulfurization, by heating. Ethyl 4-(o-aminophenyl)-3-thioallophanate (IIIb) and ethyl 4-(o-hydroxyphenyl)-3-thioallophanate (IIIc), which do not afford any cyclization product in aprotic solvents, can also be cyclized to ethyl 2-benzimidazolecarbamate (IVb) and ethyl 2-benzoxazolecarbamate (IVc), respectively, by heating in strongly protic solvents. Heavy metal ions and/or hydrogen peroxide, which are known as soft acids, accelerate desulfuric ring-closure reactions in the presence of basic anions.
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SATORU TANAKA, KAZUNORI HASHIMOTO
1973 Volume 93 Issue 8 Pages
982-990
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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A new tricyclic ring system, dibenz[b, g][1, 5]oxazocine derivatives (VIII), was synthesized. In this reaction, a 16-membered ring compound (IX) was obtained as a byproduct besides the objective VIII, and formation ratio of these two compounds varied with reaction conditions. Catalytic reduction of the 6-benzyl compound (VIII-5) gave 6, 7-dihydro-5H-dibenz[b, g][1, 5]oxazocine (X) and various derivatives of X were prepared. 6-(ω-Alkylaminoalkyl)-6, 7-dihydro-5H-dibenz[b, g][1, 5]oxazocines (XXVI) and 5, 13-bis(ω-dialkylaminoalkyl)-2, 3-, 7, 8-, 10, 11-, 15, 16-tetrabenzo-1, 9-dioxa-5, 13-diazacyclohexadeca-2, 7, 10, 15-tetraenes (XXVII) were synthesized.
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SATORU TANAKA, KAZUNORI HASHIMOTO, HIDEAKI WATANABE
1973 Volume 93 Issue 8 Pages
991-996
Published: August 25, 1973
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New tricyclic dibenz[b, g][1, 5]thiazocine derivatives (III) were synthesized by the route shown in Chart 1. In this condensation reaction, a 16-membered ring compound (IX) formed as a by-product, the formation ratio of which varied under reaction conditions. Heating of dibenzylamine (X) with sulfur afforded thiobenzoylbenzylamine(XII) and not 6, 7-dihydro-5H-dibenz[b, g][1, 5]thiazocine (XI). 6-(ω-Alkylaminoalkyl)-6, 7-dihydro-5H-dibenz[b, g][1, 5]thiazocine (XVIII) derivative was synthesized by the route shown in Chart 4.
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SATORU TANAKA, HIDEAKI WATANABE, YOSHITAKE OGATA
1973 Volume 93 Issue 8 Pages
997-1002
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Condensation of bis(2-bromomethylphenyl) sulfoxide (VI) or sulfone (VII) with primary amines afforded dibenz[b, g][1, 5]thiazocine oxides (II or III). In this reaction, by-product formation of a bimolecular compound (IV), as was the case in the reaction of bis(2-bromomethylphenyl) sulfide (V), was not observed. Catalytic reduction of 6-benzyl-6, 7-di-hydro-5H-dibenz[b, g][1, 5]thiazocine 12, 12-dioxide (5) afforded 6, 7-dihydro-5H-dibenz-[b, g][1, 5]thiazocine 12, 12-dioxide (XI). The benzyl protons at 5- and 7-positions in II and III appear in their nuclear magnetic resonance spectrum as an AB-type double doublet. 6-(Alkylaminoalkyl)-6, 7-dihydro-5H-dibenz[b, g][1, 5]thiazocine oxides (XIII) were synthesized by the route shown in Chart 3.
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SATORU TANAKA, YOSHITAKE OGATA
1973 Volume 93 Issue 8 Pages
1003-1007
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Condensation of 4-chloro-2, 2'-di(bromomethyl)diphenyl ether (X) and ω-aminoalcohol (XI) gave 3-chloro-6-(ω-hydroxyalkyl)-6, 7-dihydro-5H-dibenz[b, g][1, 5]oxazocine (XII), with a 16-membered ring dimer (XIII) as a by-product. The formation ratio of these two products varied with reaction conditions. 3-Chloro-6(ω-alkylaminoalkyl)-6, 7-dihydro-5H-dibenz[b, g][1, 5]oxazocine (XV) was also synthesized.
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MASAKATSU SONE, YOSHINORI TOMINAGA, REIKO NATSUKI, YOSHIRO MATSUDA, GO ...
1973 Volume 93 Issue 8 Pages
1008-1013
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Methyl 1-cyano-2-methylthio-3-nitrocrotonate was reacted with hydrochloric acid under various conditions and 2, 5-dihydro-2-hydroximino-5-imino-4-methoxycarbonyl-3-methylthiofuran monohydrochloride, 2, 5-dihydro-2-hydroximino-4-methoxycarbonyl-3-methylthiofuran, and α-methylthio-β-methoxycarbonylmaleic anhydride were synthesized. The mutual relationship of these products was clarified.
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JUTARO OKADA, TOSHIYUKI ESAKI
1973 Volume 93 Issue 8 Pages
1014-1018
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Carbon-13 nuclear magnetic resonance (NMR) spectra of nine kinds of mono-substituted barbituric acid derivatives were measured. Two conclusions were obtained from the analysis of carbon-13 NMR spectra. (1) The so-called additive law is applicable to chemical shifts of the carbon at 5-position. (2) There is a correlation between chemical shifts of the carbon at 5-position and pK
a, values, except in barbituric acid and 5-methylbarbituric acid.
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MINORU HASEGAWA, TOSHIHIKO OKAMOTO
1973 Volume 93 Issue 8 Pages
1019-1023
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Reaction of various kinds of nitroquinoline with hydroxylamine in potassium hydroxide alkalinity afforded a novel product, furazanoquinoline, besides the known amino derivatives. The products obtained were furazano[3, 4-f]quinoline (XII) from 5-nitroquinoline (VIII) and 6-nitroquinoline (XIII), and furazano[3, 4-h]quinoline (XVII) from 7-nitroquinoline (XV) and 8-nitroquinoline (XVIII). The same reaction progresses with 3-nitroquinoline (II) but the nitro group is substituted with the reagent in the case of 4-nitroquinoline (V). 6, 8-Diamino-5-nitroquinoline (XI) obtained by the reaction of VIII with hydroxylamine was found to be formed via 6-amino-5-nitroquinoline (X).
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MINORU HASEGAWA, TOSHIHIKO OKAMOTO
1973 Volume 93 Issue 8 Pages
1024-1033
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Reaction of 5-nitroquinoline (I) with hydroxylamine was examined and the following reaction mechanism was presumed. In X, the ring hydrogen at the position to which hydroxylamine has added, makes a proton shift to both the nitrogen in the hydroxylamino group and oxygen in the nitro group, and two kinds of reaction progresses. The former reaction route (path a) produces 6-amino derivative (III) and the latter route (path b) gives furazano[3, 4-f]quinoline (VIII). The N-O bond in hydroxylamine is cleaved by the reaction of path a but remains in the molecule by the reaction of path b. In contrast, the N-O bond in hydroxylamine-O-sulfonic acid tends to be severed by the effect of the sulfo group and its reaction with I produces a large quantity of III, with only a minute amount of VIII. When the site of the reaction with reagents is conjugated with the ring-nitrogen in quinoline, formation of furazan compound is small.
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TETSUZO KATO, YUTAKA YAMAMOTO, SHIRO TAKEDA
1973 Volume 93 Issue 8 Pages
1034-1042
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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The reaction of ketene acetals (IIa-d) with primary amine (Ia-j) gave imino ether derivatives (III) in a good yield. Benzylamine (Ia) reacted with ketene acetals (IIa-c) to give amidine derivatives (IV), besides the formation of III. Reaction of p-nitroaniline (Ic) with IIa gave ethyl N-(p-nitrophenyl)acetimidate (IIIca) and ethyl N-(p-nitrophenyl)-3-ethoxycrotonimidate (VI). 4-Aminopyridine l-oxide (Ij) reacted with IIa to give ethyl N-(4-pyridyl 1-oxide)acetimidate (IIIja) and ethyl N-(4-pyridyl)acetimidate(IIIga). On treatment with dilute acid, III were hydrolyzed into amines, amidines, esters, and amides.
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SHOJIRO YURUGI, KATSUMI ITOH, AKIO MIYAKE, KIYOSHI OMURA
1973 Volume 93 Issue 8 Pages
1043-1051
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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The reaction of 5, 8-dimorpholino-2-phenyl-3, 4-dihydropyrimido[4, 5-d]pyridazine (IIa) with equimolar benzyl bromide and sodium hydride afforded 1-benzyl-5, 8-dimorpholino-2-phenyl-1, 4-dihydropyrimido[4, 5-d]pyridazine (IIIa), accompanied by a small amount of 3-benzyl-5, 8-dimorpholino-2-phenyl-3, 4-dihydropyrimido[4, 5-d]pyridazine (IVa). When IIa was treated with two equimolar benzyl bromide and sodium hydride, 1, 4-dibenzyl-5, 8-dimorpholino-2-phenyl-1, 4-dihydropyrimido[4, 5-d]pyridazine (Va) was formed in a good yield, which was converted to 4-benzyl-5, 8-dimorpholino-2-phenyl-3, 4-dihydropyrimido[4, 5-d]pyridazine (VIa), a diuretic agent, by hydrolysis with 10% HCl.
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TOSHIHIRO ISHIGURO, YOSHIKAZU KONDO, TSUNEMATSU TAKEMOTO
1973 Volume 93 Issue 8 Pages
1052-1057
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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Several chemical reactions of epoxylathyrol
3, 4) (I) were investigated. Catalytic hydrogenation of I gave dihydro I compound, mp 65-68°. Treatment of I with perbenzoic acid gave an epoxy derivative (III), mp 198-200°. Mild alkaline hydrolysis of I yielded a triol, mp 207-209°, C
20H
30O
5·H
2O, which readily underwent addition with diazomethane to give a pyrazole derivative, mp 100-102°, C
21H
32O
5N
2·H
2O. Treatment of I with oxalic acid in glacial acetic acid gave a product (IX), mp 207-209°, C
33H
42O
10·H
2O, which exhibited a free hydroxyl absorption at 3450 cm
-1 and lost the conjugated carbonyl group in its infrared spectrum. In the nuclear magnetic resonance spectrum of IX, a methyl group attached to the double bond and the olefinic proton disappeared, and three acetyl groups appeared at δ1.99, 2.04, and 2.21, indicating that one new acetyl group was formed. The methine carrying the new acetyl group, appeared as a doublet at δ4.62 (J=8.0 Hz), indicating a partial structure of [chemical formula]. The spectral properties could be explained with structure IX. This acid-catalyzed transannular cyclization would be initiated by a nucleophilic attack to yield an intermediate (IX-A), which would undergo cleavage of the epoxy ring (IX-B) followed by transannular addition to give compound IX. On the other hand, treatment of I with hydrogen halides in tetrahydrofuran gave the corresponding halides, C
32H
41O
8Cl (VII), mp 219-221°, C
32H
41O
8Br (VIII), mp 175-178°, whose epoxy ring would be opened and hydrogen halide added to it.
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YASUYOSHI NOGAMI, YUICHI KAWAZOE, TANEZO TAGUCHI
1973 Volume 93 Issue 8 Pages
1058-1063
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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An asymmetric synthesis of α-amino acids was attempted through Neber rearrangement of (-)-menthyl N-chloroimidate by treatment with a base. As a result, L-phenylglycine, L-alanine, L-phenylalanine, and L-leucine were obtained, optical purity of the isolated products being 27%, 33%, 62%, and 75%, respectively. The asymmetric induction occurred to a much less extent, when (-)-2-methyl-1-butanol was used in place of (-)-menthol.
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SUNAO FURUKAWA, TOSHIO KINOSHITA, MITSUAKI WATANABE
1973 Volume 93 Issue 8 Pages
1064-1068
Published: August 25, 1973
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Dimethyloxosulfonium benzoylmethylide and dimethylsulfonium benzoylmethylide were found to react with quinoline 1-oxide in the presence of an acylating agent, producing dimethyloxosulfonium 2-quinolylbenzoylmethylide and dimethylsulfonium 2-quinolylbenzoylmethylide, respectively. Similar reaction products were obtained by the reaction of dimethyloxosulfonium benzoylmethylide with 4-methylquinoline 1-oxide, isoquinoline 2-oxide, and quinoxaline 1-oxide, but not with pyridine 1-oxide.
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KOUICHIRO UMEMOTO, KEIICHIRO HOZUMI
1973 Volume 93 Issue 8 Pages
1069-1083
Published: August 25, 1973
Released on J-STAGE: May 30, 2008
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The present experiment was carried out to obtain some information regarding formation mechanism of crystalline inorganic components in plants, using the "low-temperature plasma ashing method for biological materials" originated with K. Umemoto. The crystal image in a leaf was followed through its life cycle and difference in the life cycle to various tissue cells in the same plant was examined. The sample material was a leaf (minus the petiole) from weeping willow (Salix babylonica LINN.), measuring about 6 to 128 mm in length, collected during March to June in Kyoto city. The crystal image of calcium oxalate that appears with growth of the leaves was followed. It was thereby found that the crystal form of calcium oxalate that appears first in the willow leaf is an aggregate, and that solitary crystals appear after a certain period. In addition, the pattern of crystal distribution in the costa, mesophyll, apex, and margin of the leaves at different periods of observation was found to change markedly. Examination must be made in future on the correlation, if any, between this change in the pattern and physiology of the plants.
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TETSUZO KATO, TOYOHARU HOZUMI
1973 Volume 93 Issue 8 Pages
1084-1086
Published: August 25, 1973
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2-Pyrrolidylidene-acetone (VIIa) reacted with diketene to give 8-acetyl-5-methyl-1, 2, 3, 7-tetrahydroindolizine-7-one (VIIIa). Similarly, ethyl 2-pyrrolidylidene-acetate (VIIb) and 2-pyrrolidylidene-acetonitrile (VIIc) afforded 8-ethoxycarbonyl-5-methyl-1, 2, 3, 7-tetrahydroindolizine-7-one (VIIIb) and 8-cyano-5-methyl-1, 2, 3, 7-tetrahydroindolizine-7-one (VIIIc), respectively. Reaction of 4-methylamino-3-penten-2-one (IX) with diketene gave 3-acetyl-1, 2, 6-trimethyl-4-pyridone (X).
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MASAHIRO NAGAI, KAZUO IZAWA, FUSAKO MIZOGUCHI
1973 Volume 93 Issue 8 Pages
1087-1088
Published: August 25, 1973
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From the leaves of Callicarpa japonica THUNB. and C. japonica THUNB. var. luxurians REHD., 4', 5, 6, 7-tetramethoxyflavone (II) was isolated and it was found to have fish-killing activity. Its toxicity to Oryzias latipes TEMMINCK et SCHLEGEL was found to be one-half of that of 5, 6, 7-trimethoxyflavone (I).
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