After the administration of hemolysate or its extract to rats, the liver was examined histologically. In experiments of short duration, slight degeneration of the liver cells was observed using both materials. After 3 months of weekly administration of the hemolysate, fibrous changes were found. From these results, it was suggested that the hemolysate was toxic to liver cells and there may exist some unknown substances in the hemolysate without hemoglobin.
A huge, calcified intracranial mass continuous with the left frontal bone was revealed in the plain craniogram of an 11-year-old boy suffering from convulsive seizure. Preoperatively meningioma involving the left frontal bone was suspected by tomography, cerebral angiography and brain scan. Total removal of a yellowish gray, hard and sharply circumscribed tumor weighing 230g together with the left frontal bone was successfully performed. The tumor was compressing frontal lobes and was not infiltrative bilaterally. Microscopically numerous bone trabeculae associated with the osteocytes were scattered in the intermingled fibrous connective tissue. At the junction of the skull and the tumor, the dura mater was folded and the bone trabeculae with a high osteoblastic activity in the tumor were continuous with the thickened inner table of the skull. A typical lamellar appearance was seen under polarized light. The tumor was finally diagnosed as ossifying fibroma which miginated in the left frontal bone and developed into the cranial cavity compressing the brain. Differential diagnosis between ossifying fibroma and fibrous dysplasia was discussed especially from the histological and pathogenetical points of view.
For a period from 1956 to 1968 environment factors in various places on an oil tanker sailing on the Persian Gulf route were studied during her voyage, and it was found that the environmental temperature was improved obviously after installation of an air-conditioning equipment. Physique of the seamen was not much different from those of land workers but they were rather overweight as known from their body weight and subcutaneous fat. It was considered to be due to the rationalization and automation of equipments on board, which caused the limited number steps per day and lack of exercise. Blood pressure had been relatively low but, after installation of the air-conditioning equipment, mean values of the systolic and diastolic pressures indicated a slight rise. Total cholesterol in serum was found to be low in seamen. It was assumed to be due to insufficient nutrition qualitatively, in spite of being supplied with enough calories. As there was an individual likes and dislikes in food, there were a lot of leftover food in every meal, which were supplied with extra night snacks at their own expenditure.
To study the bonding mechanism and tooth damage in direct bonding of brackets to the tooth surface (Direct Bonding System), a scanning electron microscope was used to observe teeth in vivo. It was found that polishing removed the cuticle, the presence of which affected bonding strength. The creation of many microscopic crevices through acid etching, combined with the application of silane and adhesive, aided in the penetration and firm contact necessary for a strong bond. From the observations, it was concluded that tooth surface damage in the bonding mechanism of DBS was negligible.