A case of granulocytic sarcoma of the jaw is presented, which developed 1 year and 6 months before the onset of acute myelogenous leukemia. Granulocytic sarcomas before the involvement of the peripheral blood and marrow were also found in the lymph nodes, uterine cervix, forearms and ribs. The diagnosis of granulocytic sarcomas was confirmed retrospectively with naphthol AS-D chloroacetate esterase and electron microscope.
An autoradiographic study using 3H-thymidine (3H-TdR) was carried out to investigate which cells migrate from the pulp explant of the rat incisor in vitro. The cells close to the arterioles (perivascular cells) were especially labeled after 3H-TdR incubation following the dissection of the pulp explant. In tracing these 3H-TdR-labeled perivascular cells, about 15 percent of the outgrowth cells were the perivascular cells after 2 days of culture and these perivascular cells had a high mitotic activity in vitro. On the other hand, it was ascertained that the odontoblasts in the pulp explant underwent necrotic changes and that the odontoblasts had no ability to migrate from the pulp explant.
In order to investigate the influence of diabetic treatment, especially insulin treatment on diabetic retinopathy, disc-to-macula circulation time, platelet aggregation and blood viscosity were observed before and after treatment for 5 years in 42 diabetics (17 insulin-dependent diabetics [IDD] and 25 noninsulin-dependent diabetics [NIDD]).
The disc-to-macula circulation time was significantly correlated with the mean blood glucose level.
The platelet aggregation in IDD was enhanced significantly as compared with that in NIDD, however after treatment with insulin, the platelet aggregation revealed a significant decrease in IDD.
The inter-period changes in the disc-to-macula circulation time before and after treatment in IDD were correlated with those of platelet aggregation, but not with those of blood viscosity.
These results suggested that although the blood glucose level was considered to be one of the important factors influencing the retinal circulation, insulin had a direct effect on the platelet function in improving the retinal circulation in addition to lowering the blood glucose level.