All issues
Successor
Volume 12, Issue 1
Displaying 1-11 of 11 articles from this issue
- |<
- <
- 1
- >
- >|
-
Hideo UEDA, Yoshimi SAITO, Iwao ITO, Hisomu YAMAGUCHI, Tadanao TAKEDA, ...1971 Volume 12 Issue 1 Pages 1-21
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSAn elevated titer of anti-aorta antibodies was detected with a significantly higher frequency in cases of aortitis syndrome than in those of other diseases by the complement fixation test and tannic acid hemagglutination test. This finding indicates participation of immune mechanism in the development of aortitis syndrome.
The direct fluorescent antibody technique disclosed that aorta antigens are present in the media and the adventitia in a reticular form surrounded by the elastic fibers.
A lower titer of anti-aorta antibodies was found with aorta, previously treated with collagenase, than that with untreated aorta, suggesting that collagen might be the main part of the aorta antigen.
Boyden's tannic acid hemagglutination technique as modified by Kumagai, was used to study streptococcal type specific antibodies. Most sera from patients with aortitis syndrome showed significantly high titers in one or more types. It is suggested that streptococcal infection may be one of the triggers working in its origin of the development of aortitis syndrome.View full abstractDownload PDF (1568K) -
Masaru ISHII1971 Volume 12 Issue 1 Pages 22-39
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA glycoprotein which had inhibitory action in vitro and in vivo on plasma and tissue lipoprotein lipase was extracted from human sera and partially purified by Hollett's procedure. Inhibitory action of the glycoprotein extracted from sera of aged persons as well as patients with arteriosclerosis showed to be stronger than that from sera of young adults.
On the other hand, a crude glycoprotein extracted from various tissues of dog by method of Radhakrishnamurthy et al. was found to act as a potent inhibitor of dextran-sulfate induced human plasma lipoprotein lipase, Particularly the crude glycoprotein obtained from the liver showed the strongest inhibitory effect compared to the other tissues of the dog. The liver possessed the largest quantity of the glycoprotein per weight.
Further purification of the crude glycoprotein extracted from human sera was made by isoelectric focusing. It was confirmed by electrophoretic and immuno-electrophoretic analyses that a certain alpha-2 acid glycoprotein had an inhibitory activity on lipoprotein lipase.
To the male rats (S.D strain), 10mg. of the crude glycoprotein extracted from sera was administered daily for 10 weeks intramuscularly. Activity of lipoprotein lipase in the various tissues, especially in aorta, was found to be lower than that of control rats. Histological examination also showed deposition of characteristic lipid droplets in aorta and arteries near pancreas, and intimal thickening of small arteries of the heart and spleen.View full abstractDownload PDF (2497K) -
Immunological Studies and Review of Literatures on Autopsied Cases in JapanKikuo MACHIDA, Kinnojo IGUCHI, Yoshimi SAITO, Yasuro SUGISHITA, Masahi ...1971 Volume 12 Issue 1 Pages 40-49
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA family of cardiomyopathy including 1 case of postmortem study was reported. The autopsied findings of similar cases reported in Japan were reviewed and compared with our cases. It was found that pathological findings of all reported cases fell into the third type characterized by the hypertrophy of myocardial fibers with diffuse fibrosis according to Barry and Hall's classification. Coagulation defect, probably due to circulating anticoagulant, was noticed in 1 case; it returned normal after a short course of steroid therapy. The presence of anti-heart antibody and type specific antibody against beta-hemolytic streptococci was shown in some of our cases, and the role of immunological abnormalities as a possible etiological factor was discussed.View full abstractDownload PDF (2122K) -
Part I. MethodYasuro SUGISHITA, Shigekoto KAIHARA, Hisakazu YASUDA, Masahiro IIO, Sa ...1971 Volume 12 Issue 1 Pages 50-59
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSIn 5 anesthetized dogs, "carbonized microsphere" labeled with Sr-85 was injected into left atrium, and then the heart was excised and divided into 4 heart chambers and interventricular septum. Total and regional myocardial blood flow was calculated from the relative distribution of radioactivity, the weight of each myocardium samples and cardiac output, by the principle that the injected microspheres are distributed in the heart in proportion to the distribution of the regional myocardial blood flow. Total myocardial blood flow was 5.35±1.00% of the cardiac output, and the average myocardial flow per 100Gm. of the myocardium was 76.3±15.5ml./min./100Gm. Right ventricle was supplied significantly less blood flow than left ventricle. The blood flow in the basal portion of right ventricle was less than that in the apical. There was no significant difference among the perfusion areas of left ventricle, but endocardial side of left ventricle was supplied with more flow than epi-cardial side. Interventricular septum had a similar pattern of flow distribution to left ventricular free wall. The total coronary sinus flow was collected during the injection of the microspheres using a cannula introduced into coronary sinus via right auricular appendage, and no significant coronary arteriovenous shunt was found.View full abstractDownload PDF (492K) -
Part II. Heterogeneity of Myocardial Blood Flow in Left Ventricle Induced by Isoproterenol InjectionYasuro SUGISHITA, Shigekoto KAIHARA, Hisakazu YASUDA, Masahiro IIO, Sa ...1971 Volume 12 Issue 1 Pages 60-67
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSIn dogs anesthetized with sodium pentobarbital, myocardial distribution of blood flow was measured by injecting "carbonized microspheres" labeled with Sr-85 or Ce-141 into left atrium. The changes of myocardial segment length was also measured by 2 strain gauge arches sutured on the apical and basal portions of left ventricular surface.In the control state, homogeneous myocardial distribution of blood flow was observed in the left ventricle. One and half min. after injecting 2μg./Kg. of isoproterenol, myocardial blood flow decreased in the endocardial side, which was marked in the apical portion, while it increased slightly in the epicardial side. The contraction of the myocardium increased at the apical portion and decreased at the basal portion. Five min. after the injection of isoproterenol, myocardial blood flow at the endocardial side of the anterior apical portion increased, whereas other parameters measured returned toward the control levels.The relation between heterogeneous distribution of myocardial blood flow and the heterogeneous contraction of myocardium was discussed.View full abstractDownload PDF (1047K) -
Fumio SHIBAYAMA, Susumu MIZOGAMI, Hirofumi SOKABE1971 Volume 12 Issue 1 Pages 68-78
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSCardiovascular (CV) reactivity to norepinephrine (NE) and angiotensin II (Ang) was determined in the spontaneously hypertensive rat (SHR), and in the rat made hypertensive by clipping the renal artery and contralateral nephrectomy, or by deoxycorticosterone and salt administration. The full dose-response curves were obtained without anesthesia after pithing, decerebration, and vagotomy. CV reactivity to Ang was increased in the SHR, but only increased slightly in hypertension by clipping. This change in CV reactivity does not explain existent high blood pressure, since Ang content of the blood in the hypertensive states is not always increased. CV reactivity to NE was essentially unchanged in the 3 types of hypertension. The results indicate that the observed high blood pressure is not due to an increased sensitivity to NE in the hypertensive rats, and that NE must be available in a larger amount at the receptor sites in the cardiovascular system to maintain the higher blood pressure.View full abstractDownload PDF (484K) -
I. Effect of Chronic Administration of HydralazineTeruo OMAE, Kenjiro TANAKA1971 Volume 12 Issue 1 Pages 79-83
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSRelease of renal pressor substances ("renin") was tested by grafting of a kidney onto a bilaterally nephrectomized rat. Partially infarcted kidneys showed a significant decrease in "renin" release compared to control kidneys, whether they were derived from rats developing hyper-tension or from those not accompained by hypertension because of the treatment of chronic oral administration of hydralazine. "Renin" release from control kidneys was neither affected by hydralazine treatment.View full abstractDownload PDF (246K) -
II. No Protective Action of Infarcted Kidneys against Hemorrhagic ShockKenjiro TANAKA, Teruo OMAE1971 Volume 12 Issue 1 Pages 84-89
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSIn an attempt to observe whether partially infarcted kidneys possess a protective action against hemorrhagic shock, survival time and reduction rate in blood pressure following hemorrhage were compared between rats with partial renal infarction accompanied by contralateral nephrectomy and rats with uni- or bilateral nephrectomy. Survival time was not significantly different in rats with partial renal infarction from that in unior bilaterally nephrectomized rats, although reduction rate in blood pressure appeared to be somewhat smaller in uninephrectomized rats than in the others. When the kidney was grafted onto a nephrectomized rat with hemorrhagic hypotension, a definite vasopressor activity was demonstrable of untouched control kidneys but not of infarcted kidneys. The significance of these findings was discussed.View full abstractDownload PDF (623K) -
Shin-ichi SHIINA, Vinci MIZUHIRA1971 Volume 12 Issue 1 Pages 90-95
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESS(1) Sodium dihydroxytartrate osazone added to a fixative solution was used for the subcellular localization of calcium ion in the cardiac muscle tissue.
(2) In the control group of mice, the resulting precipitate distributed inside the terminal cisternae and in a lesser amount inside and around the longitudinal tubule of the sarcoplasmic reticulum. There were also occasional deposits in the myofibrils, especially over the Z line.
(3) In the other group with administration of therapeutic ouabain dose (0.15μg.), the significantly increased amount of precipitate was observed in the same regions as in the control.
(4) The increased calcium was considered to be exchangeable calcium and to be related to the inotropic action of the cardiac glycosides.View full abstractDownload PDF (2249K) -
Kunito IWABUCHI, Katuhiro NIITU1971 Volume 12 Issue 1 Pages 96-104
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA case of levocardia with anomalous venous drainage of all right pulmonary veins to the right atrium, a sinus venosus type atrial septal defect, an anomalous inferior vena cava with azygos continuation, alterations of sinoatrial rhythm, associated with partial situs inversus viscerum was reported. The physiologic abnormalities of the heart were corrected successfully. A brief review on the other 8 reported patients of levocardia with complicated cardiac malformations treated surgically is presented.View full abstractDownload PDF (2156K) -
Shin-ichiro OHKAWA, Masaya SUGIURA, Hiroyuki SHIMADA, Ryozo OKADA1971 Volume 12 Issue 1 Pages 105-110
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA 73-year-old male, with complaints of chest pain and dyspnea died after the recurrent attacks of congestive heart failure on the base of aortic regurgitation. Autopsy showed the dissecting aneurysm of the posterior sinus of Valsalva caused by syphilitic mesoaortitis. Rarity of the acquired aneurysm of the aortic sinus was emphasized.View full abstractDownload PDF (1983K)
- |<
- <
- 1
- >
- >|