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Volume 27 (1986)
- Issue 6 Pages 777-
- Issue 5 Pages 621-
- Issue 4 Pages 443-
- Issue 3 Pages 279-
- Issue 2 Pages 145-
- Issue 1 Pages 1-
Volume 27, Issue 3
Displaying 1-17 of 17 articles from this issue
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A Comparison between a Japanese Community Hospital and Western CountriesToru IKEGAWA, Masao CHINO, Fumihiko USUBA, Kuni NISHIKAWA, Yoshiro NAK ...1986 Volume 27 Issue 3 Pages 279-285
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe purpose of our study was to determine differences in coronary lesions after myocardial infarction between Japan and Western countries. One hundred ninety-two patients under 69 years of age admitted to our CCU were diagnosed as having an acute myocardial infarction. One hundred thirty of 153 surviving patients received coronary arteriography, and 12% had zero-vessel, 42% single-vessel, 25% two-vessel and 12% three-vessel coronary artery disease. Of 113 patients without a previous history of myocardial infarction, 12% had zero-vessel, 44% single-vessel, 27% two-vessel and 17% three-vessel disease. We compared these results with the reports of three similar studies from Western countries. The percentage of multivessel patients in our study was the lowest among the four studies (p<0.05). Coronary lesions in patients without a previous history of myocardial infarction differ from reports in the United States (p<0.05). These results may suggest that we should carefully evaluate the reports of secondary prevention for chronic myocardial infarction, considering the different severity of coronary lesions in each country.View full abstractDownload PDF (340K) -
Comparison with the Other Stress Testing MethodsTakanori FUJITA, Ryuichi AJISAKA, Ryuma MATSUMOTO, Kaname IIDA, Keiji ...1986 Volume 27 Issue 3 Pages 287-297
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSSince a dynamic exercise stress test cannot always be performed adequately in elderly patients, an alternative method is needed for evaluation of coronary reserve. We studied two-dimensional echocardiographic (2-DE) and electrocardiographic (ECG) responses to infusion of isoproterenol (ISP) at a rate of 0.02μg/Kg/min in 40 elderly patients with chest pain. The results were compared with exercise ECG (EX-EGG) tests and exercise radionuclide angiocardiography (EX-RNA) in 13 of these patients. No serious complications were encountered in the ISP test. The diagnostic sensitivity for coronary artery disease (CAD) was 71% for ISP-2-DE, 71% for ISP-ECG, 86% for EX-ECG and 71% for EX-RNA. The specificity for CAD was 83% for ISP-2-DE, 33% for ISP-ECG, 50% for EX-ECG and 100% for EX-RNA. In conclusion, the ISP-2-DE test is a safe, easily available and useful method for the assessment of coronary artery disease in elderly patients.View full abstractDownload PDF (933K) -
Gian Paolo ROSSI, Achille Cesare PESSINA, Andrea SEMPLICINI, Gian Pier ...1986 Volume 27 Issue 3 Pages 299-305
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSRecurrence of hypertension is reported in a considerable percentage of renovascular hypertensive patients treated by percutaneous transluminal angioplasty (PTRA); among the possible mechanisms for these failures, restenosis of the renal artery is the only correctable one. Since captopril stimulates renin secretion to a greater extent in renovascular than in essential hypertensive patients, we determined if it could be used to unmask significant restenosis in the patients with hypertension recurring after PTRA.
Follow-up study was performed in 28 patients treated with PTRA. We found that captopril caused a greater increase in peripheral plasma renin activity in 8 of 8 cases who had recurrence of hypertension and restenosis than in 13 of 15 of the patients who did not. We suggest that the determination of captopril-stimulated renin may provide a useful, simple and economical tool for the detection of restenosis after PTRA.View full abstractDownload PDF (367K) -
A Feasable Histologic Diagnostic ProcedureJosé MILEI, Rubén STORINO1986 Volume 27 Issue 3 Pages 307-319
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe Barbeito-López trichrome stain (BLTS) was compared with hematoxylin and eosin (HE), the basic fuchsin picric acid (BFP) and nitro-blue tetrazolium (NBT) dye tests. Two types of hearts were studied: a) myocardial necrosis induced by isoproterenol (ISP) in rats and b) human hearts with early coagulation necrosis (Early CN). The BLTS was much more sensitive than HE for diagnosis of Early CN in rats. By 24 hours, both BLTS and HE showed established coagulation necrosis (Established CN) although BLTS did so more clearly. In human material BLTS was a useful indicator of Early CN. It showed patchy areas of coagulation necrosis in the cytoplasm of damaged myocardial cells which were not visualized with HE. Normal myocardium remained green or pale blue. Early CN appears as patchy yellow areas while the remainder of the cytoplasm stains green. Established CN appears "golden yellow "or" orange yellow".View full abstractDownload PDF (3217K) -
Tokio NAKANE, Shigetoshi CHIBA1986 Volume 27 Issue 3 Pages 321-328
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe vascular responses of the isolated, perfused simian left circumflex coronary arteries to adrenergic agonists were compared to those of canine coronary arteries in isolated, perfused preparations. Norepinephrine and epinephrine produced only vasoconstriction in monkey arteries in contrast to vasoconstrictor, vasodilator and biphasic responses of canine coronary arteries. Isoproterenol induced a dose-dependent vasodilatation. Salbutamol, a selective beta2-agonist, produced either a slight vasodilatation or no response. Phenylephrine, a selective alpha1-agonist, usually caused a marked vasoconstriction in a dose-related manner in both preparations. Xylazine and clonidine, selective alpha2-agonists, caused a slight vasoconstriction in low doses, but these two agonists relaxed both preparations in high doses. These observations suggest that adrenoceptor subtypes may be mainly alpha-1 and beta-1 in the large coronary arteries of monkeys and dogs and that the alphaadrenoceptor is predominant in simian large coronary arteries.View full abstractDownload PDF (424K) -
Yukio MARUYAMA, Shoichi SATOH, Jun WATANABE, Kouichi ASHIKAWA, Shogen ...1986 Volume 27 Issue 3 Pages 329-343
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSWe investigated whether the relationship between the mean left anterior descending and septal coronary blood flow and the mean perfusion pressure varies with left circumflex coronary stenosis. We used excised, perfused canine heart preparations (n=10), in which variables to influence the myocardial oxygen demand and supply relation can be fairly well controlled. The results showed that coronary blood flow in the adjacent, non-stenosed coronary artery increased significantly following LCX stenosis; this increased flow was found at the same values of heart rate, left ventricular end-diastolic pressure and perfusion pressure, as those in the preischemic state. Moreover, this increased flow was also observed when the values of peak left ventricular pressure and pressure length loop area were similar between the preischemic and ischemic states. Thus, contributions of neurohumoral factors or alterations in mechanical factors determining the myocardial oxygen demand and supply relation are negligible. This increased flow may be important in maintaining overall cardiac function in cases of acute coronary stenosis or coronary occlusion.View full abstractDownload PDF (796K) -
Hasan PARVEZ, Kazuo ICHIHARA, Simone PARVEZ, Kenji SAKAI, Yasushi ABIK ...1986 Volume 27 Issue 3 Pages 345-354
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe effects of regional ischemia of the myocardium upon metabolism and catabolism of catecholamines were studied in the dog adrenal medulla. Regional ischemia was induced by ligating a small branch of the left anterior descending coronary artery for 1 or 24 hours. Sham-operated controls were run in parallel. Coronary ligation for 24 hours resulted in a decrease in the level of epinephrine and an increase in the level of dopamine in the adrenal medulla, and also resulted in an increase in the activities of the phenylethanolamine-N-methyltransferase (PNMT), monoamine oxidase, and catechol-O-methyltransferase. The results after coronary ligation for 1 hour were essentially the same as those after coronary ligation for 24 hours, except that the activity of PNMT decreased. These results suggest that both synthesis and catabolism of catecholamines in the adrenal medulla are accelerated during coronary ligation for a period of 1 to 24 hours.View full abstractDownload PDF (479K) -
Comparison between Electrical Ablation and a New Catheter Technique Using Anhydrous AlcoholMinoru MURATA1986 Volume 27 Issue 3 Pages 355-364
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSProduction of chronic complete atrioventricular block (CAVB) was attempted by two closed-chest methods in dogs. One is a modified electrical ablation method (EA), and the other is a new catheter technique to inject anhydrous alcohol into the subendocardium of the AV junction (alcohol method). EA was performed in 6 dogs and the alcohol method in 10 dogs. Chronic CAVB was produced in 5 dogs (83%) by EA and in 7 dogs (70%) by the alcohol method. Escape ventricular rhythm with narrow QRS morphology was found in 4 dogs (80%) with EA, and in 3 dogs (43%) with the alcohol method. Except for transient supraventricular tachyarrhythmias which occurred immediately after EA, both methods were performed without complication. EA had a higher success rate in producing CAVB on the narrow QRS of the escape ventricular rhythm occurred more frequently than reported in the literature and than in the case of the alcohol method. The alcohol method, though, may be superior to EA for human applications because it does not require general anesthesia.View full abstractDownload PDF (968K) -
Mordechai MANOACH, Hana NETZ, Daliah VARON, Giora AMITZUR, Martha WEIN ...1986 Volume 27 Issue 3 Pages 365-375
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSDownload PDF (672K) -
An Experimental Model for Nonrheumatic Mitral RegurgitationKouji IMATAKA, Kazuhide YAMAOKI, Akira SEKI, Yoshiaki TAKAYAMA, Jun FU ...1986 Volume 27 Issue 3 Pages 377-386
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSDownload PDF (1714K) -
Shigetoshi CHIBA, Yasuyuki FURUKAWA, Kimiaki SAEGUSA, Yasuhiro OGIWARA1986 Volume 27 Issue 3 Pages 387-394
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe cardiac effects of DM9278 were studied in isolated and blood-perfused atrial and ventricular preparations from mongrel dogs. In spontaneously beating isolated right atria, DM9278 caused positive chronotropic and inotropic responses in a dose-related manner (1-100μg). DM9278 produced relatively larger positive inotropic than positive chronotropic effects as compared with effects of aminophylline or papaverine. DM9278 increased the developed tension in left ventricles electrically driven at 1.5 -2.0Hz. Positive inotropic and chronotropic responses to DM9278 in both atrial and ventricular preparations were suppressed slightly but not significantly by 1-3μg of propranolol, which completely blocked the positive chronotropic and inotropic effects of norepinephrine (0.01-0.1μg). From these results, it is concluded that DM9278 has direct cardiotonic properties in isolated dog heart tissues, showing relatively selective positive inotropic activity.View full abstractDownload PDF (349K) -
Kazushi TSUDA, Masato KUCHII, Ichiro NISHIO, Yoshiaki MASUYAMA1986 Volume 27 Issue 3 Pages 395-402
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe present study was designed to investigate whether Caantagonists influence norepinephrine release from the sympathetic nerve endings in resistance vessels. Isolated mesenteric vascular preparations of rats, perfused with Ringer-Locke solution, were used to determine the effects of verapamil or diltiazem on norepinephrine release from sympathetic nerve terminals. Pressor responses to exogenous norepinephrine and electrical nerve stimulation were recorded, and the norepinephrine contents of the perfusate were measured before and after the electrical nerve stimulation, using high pressure liquid chromatography with an electrochemical detector. Pressor responses to exogenous norepinephrine and electrical nerve stimulation were depressed dose-dependently by verapamil and diltiazem. The inhibition of the pressor responses for nerve stimulation was greater than exogenous norepinephrine. Both verapamil and diltiazem reduced norepinephrine release from the mesenteric arterial beds after the electrical nerve stimulation. These results indicate that Ca++-antagonists, such as verapamil and diltiazem, have inhibitory effects on norepinephrine release from the sympathetic nerve endings, in addition to their direct actions on the vascular smooth muscle. It is also suggested that the presynaptic inhibitory action of Ca++-antagonists could be due to the blockade of Ca++-channels in nerve cell terminals, which may be important in the clinical use of Ca-antagonists.View full abstractDownload PDF (426K) -
Shigetoshi CHIBA, Kimiaki SAEGUSA, Yasuyuki FURUKAWA, Yasuhiro OGIWARA1986 Volume 27 Issue 3 Pages 403-411
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSCardiovascular effects of budralazine were investigated in isolated and cross-circulated dog atrial preparations. When budralazine was injected into the jugular vein of the donor dog, a hypotension was produced with slight tachycardia in a dose-related manner. At the same time, slight positive chronotropic and biphasic inotropic effects were induced in. the isolated atrium perfused with donor's arterial blood. When budralazine was injected into the cannulated sinus node artery of the isolated atrial preparation, it produced only slight negative chronotropic and inotropic responses, occasionally followed by positive responses. Vehicle injections induced monophasic negative chronotropic and inotropic effects. It is concluded that budralazine has a potent vasodilator action, a reflex-induced sympathomimetic action, but no direct cardiac stimulating properties Moreover, a direct catecholamine releasing action of budralazine does not appear to be prominent.View full abstractDownload PDF (410K) -
Wilson Pimentel FILHO, Vera GIMENES, Elia ASCER, Roberto HAENDCHEN, Am ...1986 Volume 27 Issue 3 Pages 413-419
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSSequential angiographic studies have shown that spontaneous reperfusion occurs in approximately 30 to 40% of patients during evolving myocardial infarction. However, it is difficult to establish the effects of spontaneous reperfusion on left ventricular function.
We report the case of a 65 year old woman with clinical fea tures of acute myocardial infarction with early spontaneous reper fusion and complete recovery of ventricular function 1 year later.View full abstractDownload PDF (1785K) -
Hirotaka ODA, Yoshifusa AIZAWA, Minoru MURATA, Masahito SATOH, Kaoru S ...1986 Volume 27 Issue 3 Pages 421-428
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA 26 year old female patient developed recurrent sustained ventricular tachycardia (VT) after undergoing heart surgery for the third time for chronic pulmonary regurgitation following repair of tetralogy of Fallot. At the last surgery, ventriculotomy was again performed in the outflow tract of the right ventricle. At that time, scar formation and thinning of the cardiac wall were obvious. The surgical result was excellent. Three months later, she lost consciousness. ECG showed VT which was refractory to tolerated doses of antiarrhythmic drugs. Electrophysiologic study showed fragmented activity in the outflow tract of the right ventricle during VT which could be induced and terminated by programmed electrical stimulations. DC energy delivery of 200 Joules to catheter electrodes which recorded local activity 20msec prior to the onset of the QRS of VT was successful in preventing VT. VT could not be induced by extensive programmed stimulation 1 month later.View full abstractDownload PDF (395K) -
Akihisa TOMARU, Kinjo OH, Yoshitaro MIURA, Hitoshi NAKAMURA, Makoto YO ...1986 Volume 27 Issue 3 Pages 429-436
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThis is a case report of a 57-year-old woman who was diagnosed as suffering from pheochromocytoma on the basis of serum catecholamine levels, the results of abdominal echography and CT scanning. Her fluctuating blood pressure was treated successfully by intravenous administration of diltiazem. Diltiazem elicits a marked reduction in vascular resistance. There was no evidence that diltiazem affects catecholamine secretion levels, as reported by others for nifedipine.View full abstractDownload PDF (1177K) -
Takaaki ISSHIKI, Nobuharu AKATSUKA, Hideo TSUNEYOSHI, Hiroshi OKA1986 Volume 27 Issue 3 Pages 437-442
Published: 1986
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA rare case of pheochromocytoma with wide fluctuation of blood pressure at regular 7-min intervals is described. Direct blood pressure monitoring revealed periodic changes between 120/80mmHg and 220/130mmHg. The plasma norepinephrine concentration increased selectively in parallel with the elevation of the blood pressure. The tumor was found adjacent to the left kidney, and all abnormal data improved after its resection.View full abstractDownload PDF (649K)
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