The relationship of ejection time to heart rate was examined in 19 ath-letes, 21 sedentary normal subjects and 19 patients with anginal ischemic heart disease.
Exercise tests were performed using the step test, the bicycle ergometer and the treadmill. Regression analysis was applied to the data by regressing ET on HR and delta ET on delta HR.
No significant differences were demonstrated between these groups even though the coronary insufficient patients manifested ischemic S-T segment changes and angina. Slight differences existed between the normal and is-chemic groups when the delta ET-delta HR relationship was examined, but the variance of the data challenged the significance.
The data indicated that at any level of heart rate induced by exercise, the measurement of ejection time will not distinguish between trained athletes, normal sedentary subjects or coronary insufficient patients.

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Rheumatoid agglutination reaction was studied on 40 patients with myo-cardial infarction, 11 with angina pectoris, 16 with rheumatoid arthritis and 21 healthy persons. The following results were obtained:
(1) Twenty-four of 40 cases with myocardial infarction and 12 of 16 with rheumatoid arthritis were positive in R.A. test. It was negative in all cases of angina pectoris and healthy controls. All 13 cases of positive R.A. test in myocardial infarction were titered to over 1:20.
(2) Waaler-Rose reaction was in parallel with the R.A. test mentioned above.
(3) In myocardial infarction, the serum, at the high rate, was positive in FII agglutination test and Waaler-Rose reaction as well as in R.A. test.
(4) The concentration of γ-globulin and the proportion of 19 S and 4 S fractions were increased in the positive cases of R.A. test. Serum fractionation was done by gel filtration and examined by R.A. test. R.A. test of only the 19 S component was positive in all cases.
From the results mentioned above, the significance of R.A. test and the mechanism of appearance of R.A. test were discussed.

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(1) Clinical manifestations of 16 patients of orthostatic hypotension were investigated and significant difference of these manifestations between in juvenile and senile type was described.
(2) In 8 patients of orthostatic hypotension urinary excretion of 17-hydroxycorticosteroid and 17-ketosteroid were determined before and after loading of 20 units of ACTH intramuscularly. Normal amounts of urinary corticoids excretion were proved in all patients and the response of urinary excretion of these steroids was also proved to be normal in all patients except one who showed insufficiency of 17-hydroxycorticosteroid excretion.
From the result obtained adrenocortical function has been proved to be not related to the pathogenesis of orthostatic hypotension.

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Coronary circulation time was measured in 17 closed-chest dogs. Meas-urement was made by injecting P³² into the left ventricle, and detecting its arrival into the right ventricle with a catheter type micro G-M counter in situ. This technic was devised to exclude sources of significant error inherent to conventional dye dilution technic.
Average coronary circulation time in dogs was 2.2 (0.9-3.8) sec., and was significantly shorter than that reported in published works. Appearance of P³² in the superior and inferior vena cava through systemic circulation took 5.0 and 4.6 sec. on average, respectively, occurring appreciably later than that in the right ventricle through coronary circuit. The "coronary" dilution curve, however, could not be separated from "systemic" one in the right ventricle.
Discussion was also made about characteristics of the micro G-M counter, and it was suggested to be useful for in vivo measurement of radioisotopes in various ways.

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The action potential of the renal nerve and the renal blood flow were recorded simultaneously on anesthetized dogs, and following results were obtained.
(1) By the common carotid occlusion, the renal nerve discharge was mostly increased. The increase in the discharge was usually accompanied with the renal vasoconstriction, and never with the renal vasodilatation.
(2) The increase in the renal vascular resistance during the carotid oc-clusion was depressed by the cutting of the renal nerve.
(3) By the release of the occlusion temporary diminution in the renal nerve discharge and the renal vasodilatation were observed.
(4) By the stimulation of the central end of the divided cervical vagal nerve, the response in the renal nerve discharge was various. The increase in the discharge was accompanied with the renal vasoconstriction, while the de-crease in the discharge with the renal vasodilatation.
(5) During the carotid occlusion and the vagal stimulation, a significant correlation was observed between the changes in the blood pressure and renal vascular resistance in the group with the increased discharge.

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The left subclavian artery was anastomosed with the left main coronary artery in 6 dogs, and the left internal mammary artery with the right coronary artery in 8 dogs, by the left thoracotomy. The procedures were performed using the extracorporeal circulation and hypothermia to 20°C, which made the occlusion of coronary blood flow possible for 50 min. without remarkable myocardial damage. The most difficulty in these operations was bleeding from the anastomosis, which had to be controlled by the careful suture techni-que.

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In sum, pioneering accomplishments have been made in the application of biophysical concepts and methods to electrocardiography and there is great promise for their facility and power. It is recommended that the International Society of Cardiology encourage and support the orderly transition into effective application of these new tools. However, it is found that the actual evidence for superior diagnosis from these methods is preinlimary and that there remain practical and theoretical impediments to their wider utilization. It is considered essential that the new methods retain the contribution to know-ledge of the old and during the transition remain as nearly compatible as possible. In this way experience and familiarity in cardiological practice will develop without reaction and implementation of quantitative methods will be expedited.

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