(1) The bathing cure in the Spa Kageyu produced a long-term hypotensive effect on the patients with hypertension.
(2) The beneficial effects of the spatreatment on hypertensive patients were not limited to the hypotensive effect alone but extended to the improvement in the ECG and renal functions and to the fall in arterial pressure of ocular fundus and in body temperature.
(3) The factor analysis with respect to the measured systolic and diastolic blood pressures, pulse pressure, pulse rate, and body temperature showed 3 independent axes, 2 of which composed a circulatory plane. The patterns of the test vectors on a circulatory system were constant until the 10th day, then changed abruptly to an opposite pattern concerning pulse rate and diastolic blood pressure on the 12-14th day.
In view of the fact that diastolic blood pressure was correlated with chemical constituents of the body fluids, further studies in this field will be carried out to elucidate the mechanism of the abrupt change in the circulatory pattern.

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(1) It would be physiological to keep the temperature of the thoracic region higher than that of the body surface under hypothermia. This consequently would exert a favorable influence on the general circulatory condition. Therefore it would be reasonable to cool from the body surface and rewarm it from the thoracic cavity. We had always used the intrathoracic rewarming.
(2) We proved in the animal experiments that hypothermia could safely be applied even to the subject with damaged myocardium when we employed intrathoracic rewarming.
(3) Ventricular fibrillation was prevented in almost all cases by selecting the drugs for anesthesia and proper use of prostigmine, and, when it did occur, was easily stopped by electric shock.
(4) We had performed 43 operations on total of 41 patients and completely cured all but 2 cases of tetralogy of Fallot.
(5) The safe time limit for cardiac occlusion under intermediate hypothermia is believed to be about 15 minutes.

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(1) A new method by which the changing volume of the heart can be recorded was devised for continuous observation of the heart as a whole.
(2) The principle on which the method is based was explained and the apparatuses used were described.
(3) The auricular and ventricular contractions in a normal case were accurately traceable by this method.
(4) Extrasystoles in a patient with mitral stenosis and insufficiency were recorded as corresponding abnormal contraction.
(5) Peculiar waves probably indicative of contraction of the major vessels, were recorded from a patient with patent ductus arteriosus.
(6) The experimental and diagnostic significance of this method seems to be nearly settled by the above described informations obtained by it.
(7) More detailed examination of this method and its improvement are being attempted.

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As the consequence of the investigation of arrhythmia and disturbance of stimulus conduction, it may be concluded as follows.
(1) Although in some cases the operation had to be postponed and N₂O anesthesia had to be used instead of ether anesthesia, since ether inhalation might cause the fall of blood pressure and the appearance of ventricular extrasystole or ventricular rhythm, the electrocardiographic changes observed during this series of open heart surgery in hypothermia were reversible and disappeared in short time spontaneously or by the treatment.
(2) The fact that these changes were observed in serious cases above 20 years of age with severely damaged myocardium and marked abnomalities of hemodynamics, suggests that operation should be performed at as young as possible.

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Hyaluronidase, A.A.N. (lathyrism factor), vitamin E, and chondroitin sulfate were given to weanling rats alone and in combinations, then vascular, bone, skin and ocular changes were studied morphologically.
(1) Vascular chages in the media, elastic fiber swelling, fragmentation and cyst formation (Medionecrosis aortae cystica) were more pronounced in hyaluronidase administered rats than those of A.A.N.
Hyaluronidase caused bone changes of osteogenesis imperfecta similar to Marfan's syndrome and kyphoscoliosis was also produced. In A.A.N. group, pronounced bone changes were not seen with exception of a case of fractured thoracic vertebrae.
(2) Medionecrosis aortae cystica can also arise from the mesoderm metabolic disorder.
(3) Marfan's syndrome and lathyrism are similar pathological conditions and the basis lies in the abnormal disorder of the mesoderm.
(4) Vitamin E and chondroitin sulfate seemed to prevent excessive vascular and bone changes when used together with hyaluronidase.
(5) No changes in the skin suggesting Ehlers-Danlos syndrome were noted after the use of hyaluronidase and A.A.N. though the skin became softer and thinner.
(6) The use of hyaluronidase and A.A.N. did not produce any eye or E.C.G. changes.

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(1) Multiple chest, esophageal, intracardiac leads and direct epicardial leads were taken in cattle and goats to study the mode of ventricular activation of ungulates.
(2) There was little difference between cattle and goat in these special leads.
(3) In direct epicardial leads the area showing QS pattern was invariably observed, and in the intraventricular tracings, QS, rS and RS patterns were noted.
(4) From the findings in direct epicardial leads and intraventricular leads, it was assumed that the ventricular activation, as a whole, was directed from apex to base, though transmural activation might play a role at least in some regions of ventricular wall. This assumption could explain well the findings of multiple chest leads and esophageal leads.

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(I) DECOMPOSITION OF THE ELECTRIC FIELD (Chapter 3)
(1) The concept "component (field) of the electric field" was introduced. The field has its own component in any direction and of any dimension.
(2) The electric field is decomposed to givendimensional components, or it is reduced to the sum of the lowerdimensional (component) fields.
(3) From (2), the electric field is reduced to the sum of the three-dimensional fields or to the sum of the threedimensional fields and a one-or twodimensional one. The three-dimensional field is regarded as equivalent to that with a single electric dipole (Chapter 2), and the one-or twodimensional field is considered to be a special field with a dipole. Thus, the electric field may be regarded as equivalent to that with electric dipoles.
(4) A scalar electrocardiogram represents a onedimensional component (field) of the electric field. Or, in catchy expression, ELECTROCARDIOGRAM IS SCALAR.
(5) The scalar electrocardiogram has hitherto been thought, as literally shown, as a component or a projection of some vectorial quantity. The above (4) is the corresponding result to this conventional view. The result (4) is appeared to be inconsistent with the result in Part I that an electrocardiogram is a vector but this is not so.
(6) A vectorcardiogram represents a threedimensional component (field) of the electric field, and does no more than this. This is the law which sets limits quantitatively to the vectorcardiography. Various methods of deriving vectorcardiogram can only determine the direction of the component field represented by the vectorcardiogram.
(II) ISOMORPHIC IMAGE OF THE ELECTRIC FIELD (Chapter 4)
(1) A geometric image of which structure is the same with that of the electric field, an "isomorphic image", is conceivable.
(2) An isomorphic image of the field is a two-dimensional cycle in the ndimensional geometric space. The "image surface" called by Frank, E. is a sort of isomorphic image of the three-dimensional field.
(3) The isomorphic image of a component field is a geometric projection of the image of the electric field.
(4) The isomorphic image of so-called transitional pathway, a closed curve on the body surface, is a one-dimensional cycle, and lies on a hyperplane. This determines the linear nature of the potentials on the pathway, and is the reason why the transitional pathway was named as straight line in the previous report.18)

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(1) We performed right heart catheterization and direct left atrial puncture. The calculated blood volume by dye dilution method was divided into 3 parts; i.e. the blood volume from the pulmonary artery to the brachial artery, from the left atrium to the brachial artery and from the pulmonary artery to the left atrium.
(2) The true lung blood volume, true left atrial blood volume and left ventricular-aortic blood volume were calculated by using above mentioned method of measurement. By this method, direct determination of the blood volume in the lung and left atrium became possible.
(3) The true lung blood volume does not reveal marked increase in acquired valvular diseases, and no marked difference in it was noticed among each type of valvular lesions.
(4) There was a relationship between the left atrial blood volume and the degree of dilatation of the left atrium determined by the X-ray findings.
(5) The comparison of the left ventricularaortic blood volume and electro-cardiographic findings confirmed the fact that an increased load of left ventricle results in a increased blood volume.

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We examined a cyanotic patient considered as congenital heart disease and found that it was due to hemoglobin M disease spectrophotometrically. Hemoglobin M was 77 per cent of the total hemoglobin. We could not find the hereditary pattern in our case.

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This report is an illustration of a case with calcified annular constrictive pericarditis showing the functional pulmonary and mitral stenosis. The brief comments were made upon the genesis of this entity and the unusual auscultatory findings.

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